FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894958162> ?p ?o ?g. }

• W2894958162 endingPage "18" @default.
• W2894958162 startingPage "8" @default.
• W2894958162 abstract "Glutathione (GSH) is an essential component of intracellular antioxidant systems that plays a primordial role in the protection of cells against oxidative stress, maintaining redox homeostasis and xenobiotic detoxification. GSH synthesis in the brain is limited by the availability of cysteine and glutamate. Cystine, the disulfide form of cysteine is transported into endothelial cells of the blood-brain barrier (BBB) and astrocytes via the system xc-, which is composed of xCT and the heavy chain of 4F2 cell surface antigen (4F2hc). Cystine is reduced inside the cells and the L-type amino acid transporter 1 (LAT1) transports cysteine from the endothelial cells into the brain, cysteine is transported into the neurons through the excitatory amino acid transporter 3 (EAAT3), also known as excitatory amino acid carrier 1 (EAAC1). The mechanistic/mammalian target of rapamycin (mTOR) and neurotrophins can activate signaling pathways that modulate amino acid transporters for GSH synthesis. The present study found that systemic L-buthionine-S-R-sulfoximine (BSO) administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6 mmol/kg of BSO depleted GSH and GSSG in the liver at 2 h of treatment. The cerebellum, but not other brain regions, exhibited a redox response. The mTOR and the neuronal growth factor (NGF)/tropomyosin receptor kinase A (TrkA) signaling pathways were activated and lead to an increase in the protein levels of the EAAT3 transporter, which was linked to an increase in the GSH/GSSG ratio and GSH concentration in the cerebellum at 0.5 and 2 h, respectively. Therefore, the cerebellum responds to peripheral GSH depletion via activation of the mTOR and NGF/TrkA pathways, which increase the transport of cysteine for GSH synthesis." @default.
• W2894958162 created "2018-10-12" @default.
• W2894958162 creator A5018320285 @default.
• W2894958162 creator A5020416466 @default.
• W2894958162 creator A5042751476 @default.
• W2894958162 creator A5076829786 @default.
• W2894958162 creator A5086090974 @default.
• W2894958162 date "2018-12-01" @default.
• W2894958162 modified "2023-09-30" @default.
• W2894958162 title "Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum" @default.
• W2894958162 cites W1481296049 @default.
• W2894958162 cites W1547339950 @default.
• W2894958162 cites W1932037753 @default.
• W2894958162 cites W1944455860 @default.
• W2894958162 cites W1971169887 @default.
• W2894958162 cites W1972009654 @default.
• W2894958162 cites W1973687895 @default.
• W2894958162 cites W1974093906 @default.
• W2894958162 cites W1976678890 @default.
• W2894958162 cites W1976955003 @default.
• W2894958162 cites W1977043703 @default.
• W2894958162 cites W1978895733 @default.
• W2894958162 cites W1979326553 @default.
• W2894958162 cites W1982146336 @default.
• W2894958162 cites W1983191290 @default.
• W2894958162 cites W1985259413 @default.
• W2894958162 cites W1985451517 @default.
• W2894958162 cites W1987150858 @default.
• W2894958162 cites W1990441398 @default.
• W2894958162 cites W1992196910 @default.
• W2894958162 cites W2004740124 @default.
• W2894958162 cites W2005796157 @default.
• W2894958162 cites W2007788761 @default.
• W2894958162 cites W2010131630 @default.
• W2894958162 cites W2011707975 @default.
• W2894958162 cites W2012645913 @default.
• W2894958162 cites W2018163444 @default.
• W2894958162 cites W2026709912 @default.
• W2894958162 cites W2028002685 @default.
• W2894958162 cites W2038478235 @default.
• W2894958162 cites W2039202482 @default.
• W2894958162 cites W2040988771 @default.
• W2894958162 cites W2050578486 @default.
• W2894958162 cites W2052425405 @default.
• W2894958162 cites W2060164934 @default.
• W2894958162 cites W2061149151 @default.
• W2894958162 cites W2061619137 @default.
• W2894958162 cites W2065993125 @default.
• W2894958162 cites W2072124236 @default.
• W2894958162 cites W2076840524 @default.
• W2894958162 cites W2080730559 @default.
• W2894958162 cites W2091175680 @default.
• W2894958162 cites W2091395194 @default.
• W2894958162 cites W2091505318 @default.
• W2894958162 cites W2091801893 @default.
• W2894958162 cites W2092885428 @default.
• W2894958162 cites W2094142417 @default.
• W2894958162 cites W2123656108 @default.
• W2894958162 cites W2132878122 @default.
• W2894958162 cites W2137621485 @default.
• W2894958162 cites W2154727263 @default.
• W2894958162 cites W2160411684 @default.
• W2894958162 cites W2169915515 @default.
• W2894958162 cites W2270862379 @default.
• W2894958162 cites W2320614058 @default.
• W2894958162 cites W2332562424 @default.
• W2894958162 cites W2336483461 @default.
• W2894958162 cites W2398568518 @default.
• W2894958162 cites W2400228640 @default.
• W2894958162 cites W2442263678 @default.
• W2894958162 cites W2507922103 @default.
• W2894958162 cites W2774330798 @default.
• W2894958162 cites W2795126113 @default.
• W2894958162 cites W2804477050 @default.
• W2894958162 cites W2896869836 @default.
• W2894958162 cites W4211242412 @default.
• W2894958162 doi "https://doi.org/10.1016/j.neuint.2018.10.007" @default.
• W2894958162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300680" @default.
• W2894958162 hasPublicationYear "2018" @default.
• W2894958162 type Work @default.
• W2894958162 sameAs 2894958162 @default.
• W2894958162 citedByCount "8" @default.
• W2894958162 countsByYear W28949581622019 @default.
• W2894958162 countsByYear W28949581622020 @default.
• W2894958162 countsByYear W28949581622021 @default.
• W2894958162 countsByYear W28949581622022 @default.
• W2894958162 countsByYear W28949581622023 @default.
• W2894958162 crossrefType "journal-article" @default.
• W2894958162 hasAuthorship W2894958162A5018320285 @default.
• W2894958162 hasAuthorship W2894958162A5020416466 @default.
• W2894958162 hasAuthorship W2894958162A5042751476 @default.
• W2894958162 hasAuthorship W2894958162A5076829786 @default.
• W2894958162 hasAuthorship W2894958162A5086090974 @default.
• W2894958162 hasConcept C181199279 @default.
• W2894958162 hasConcept C185592680 @default.
• W2894958162 hasConcept C2777476445 @default.
• W2894958162 hasConcept C2777608289 @default.
• W2894958162 hasConcept C2779201268 @default.

• next