FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894959635> ?p ?o ?g. }

• W2894959635 endingPage "1759" @default.
• W2894959635 startingPage "1749" @default.
• W2894959635 abstract "Isoflurane (ISO) is a commonly used anesthetic that offers rapid recovery for laboratory animal research. Initial studies indicated no difference in arterial Pco 2 ([Formula: see text]) or pH between conscious (NO ISO) and 1% ISO-exposed CD-1 mice. Our laboratory investigated whether arterial blood sampling with 1% ISO is a suitable alternative to NO ISO sampling for monitoring ventilation in a commonly studied mouse strain. We hypothesized similar blood chemistry, breathing patterns, and cardiovascular responses with NO ISO and 1% ISO. C57BL/6J mice underwent unrestrained barometric plethysmography to quantify the pattern of breathing. Mice exposed to hypoxic and hypercapnic gas under 1% ISO displayed blunted responses; with air, there were no breathing differences. Blood pressure and heart rate were not different between NO ISO and 1% ISO-exposed mice breathing air. Oxygen saturation was not different between groups receiving 2% ISO, 1% ISO, or air. Breathing frequency stabilized at ~11 min of 1% ISO following 2% ISO exposure, suggesting that 11 min is the optimal time for a sample in C57BL/6J mice. Blood samples at 1% ISO and NO ISO revealed no differences in blood pH and [Formula: see text] in C57BL/6J mice. Overall, this method reveals similar arterial blood sampling values in awake and 1% ISO CD-1 and C57BL/6J mice exposed to air. Although this protocol may be appropriate in other mouse strains when a conscious sample is not feasible, caution is warranted first to identify breathing frequency responses at 1% ISO to tailor the protocol. NEW & NOTEWORTHY Conscious arterial blood sampling is influenced by extraneous factors and is a challenging method due to the small size of mice. Through a series of experiments, we show that arterial blood sampling with 1% isoflurane (ISO) is an alternative to awake sampling in C57BL/6J and CD-1 male mice breathing air. Monitoring breathing frequency during 1% ISO is important to the protocol and should be closely followed to confirm adequate recovery after the catheter implantation." @default.
• W2894959635 created "2018-10-12" @default.
• W2894959635 creator A5041348431 @default.
• W2894959635 creator A5048049735 @default.
• W2894959635 creator A5060660478 @default.
• W2894959635 creator A5078728340 @default.
• W2894959635 date "2018-12-01" @default.
• W2894959635 modified "2023-10-10" @default.
• W2894959635 title "Arterial blood sampling in male CD-1 and C57BL/6J mice with 1% isoflurane is similar to awake mice" @default.
• W2894959635 cites W1506854271 @default.
• W2894959635 cites W1513562429 @default.
• W2894959635 cites W1547221141 @default.
• W2894959635 cites W1602073624 @default.
• W2894959635 cites W1721601994 @default.
• W2894959635 cites W1844005797 @default.
• W2894959635 cites W1970010351 @default.
• W2894959635 cites W1971943548 @default.
• W2894959635 cites W1977549443 @default.
• W2894959635 cites W1980908936 @default.
• W2894959635 cites W2007216402 @default.
• W2894959635 cites W2035145184 @default.
• W2894959635 cites W2039019784 @default.
• W2894959635 cites W2053964360 @default.
• W2894959635 cites W2059595333 @default.
• W2894959635 cites W2077324701 @default.
• W2894959635 cites W2077849899 @default.
• W2894959635 cites W2078267752 @default.
• W2894959635 cites W2083221955 @default.
• W2894959635 cites W2093776688 @default.
• W2894959635 cites W2093815501 @default.
• W2894959635 cites W2107516283 @default.
• W2894959635 cites W2117376136 @default.
• W2894959635 cites W2121697500 @default.
• W2894959635 cites W2124819816 @default.
• W2894959635 cites W2130668388 @default.
• W2894959635 cites W2132203563 @default.
• W2894959635 cites W2133376288 @default.
• W2894959635 cites W2138521217 @default.
• W2894959635 cites W2144166534 @default.
• W2894959635 cites W2145090050 @default.
• W2894959635 cites W2145675697 @default.
• W2894959635 cites W2159382038 @default.
• W2894959635 cites W2159775992 @default.
• W2894959635 cites W2168321271 @default.
• W2894959635 cites W2191971816 @default.
• W2894959635 cites W2321875764 @default.
• W2894959635 cites W2400226261 @default.
• W2894959635 cites W2738423495 @default.
• W2894959635 cites W2756502937 @default.
• W2894959635 cites W2793829387 @default.
• W2894959635 cites W3022099839 @default.
• W2894959635 cites W4231357104 @default.
• W2894959635 cites W4252993952 @default.
• W2894959635 doi "https://doi.org/10.1152/japplphysiol.00640.2018" @default.
• W2894959635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6737457" @default.
• W2894959635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30284518" @default.
• W2894959635 hasPublicationYear "2018" @default.
• W2894959635 type Work @default.
• W2894959635 sameAs 2894959635 @default.
• W2894959635 citedByCount "9" @default.
• W2894959635 countsByYear W28949596352019 @default.
• W2894959635 countsByYear W28949596352020 @default.
• W2894959635 countsByYear W28949596352021 @default.
• W2894959635 countsByYear W28949596352023 @default.
• W2894959635 crossrefType "journal-article" @default.
• W2894959635 hasAuthorship W2894959635A5041348431 @default.
• W2894959635 hasAuthorship W2894959635A5048049735 @default.
• W2894959635 hasAuthorship W2894959635A5060660478 @default.
• W2894959635 hasAuthorship W2894959635A5078728340 @default.
• W2894959635 hasBestOaLocation W28949596351 @default.
• W2894959635 hasConcept C116938221 @default.
• W2894959635 hasConcept C126322002 @default.
• W2894959635 hasConcept C127413603 @default.
• W2894959635 hasConcept C185592680 @default.
• W2894959635 hasConcept C200457457 @default.
• W2894959635 hasConcept C2776359302 @default.
• W2894959635 hasConcept C2778162923 @default.
• W2894959635 hasConcept C2779537118 @default.
• W2894959635 hasConcept C2988731192 @default.
• W2894959635 hasConcept C39300077 @default.
• W2894959635 hasConcept C42219234 @default.
• W2894959635 hasConcept C71924100 @default.
• W2894959635 hasConcept C73362275 @default.
• W2894959635 hasConcept C78519656 @default.
• W2894959635 hasConcept C84393581 @default.
• W2894959635 hasConceptScore W2894959635C116938221 @default.
• W2894959635 hasConceptScore W2894959635C126322002 @default.
• W2894959635 hasConceptScore W2894959635C127413603 @default.
• W2894959635 hasConceptScore W2894959635C185592680 @default.
• W2894959635 hasConceptScore W2894959635C200457457 @default.
• W2894959635 hasConceptScore W2894959635C2776359302 @default.
• W2894959635 hasConceptScore W2894959635C2778162923 @default.
• W2894959635 hasConceptScore W2894959635C2779537118 @default.
• W2894959635 hasConceptScore W2894959635C2988731192 @default.
• W2894959635 hasConceptScore W2894959635C39300077 @default.
• W2894959635 hasConceptScore W2894959635C42219234 @default.
• W2894959635 hasConceptScore W2894959635C71924100 @default.
• W2894959635 hasConceptScore W2894959635C73362275 @default.

• next