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- W2894962968 abstract "Background: Despite advances in imaging modalities, intraoperative detection of new legions (newly detected colorectal liver metastases : ND-CLM) is common in patients undergoing hepatectomy. However, clinical significance of ND-CLM is still unknown. Methods: Data of 171 patients who underwent initial hepatectomy for colorectal liver metastases after preoperative chemotherapy were reviewed from 2010 to 2015. ND-CLM were defined as metastases newly confirmed during hepatectomy by visual inspection, palpation, or intraoperative ultrasonography. Background characteristics and long-term outcomes of patients having ND-CLM were investigated. Results: Among 171 patients, ND-CLM were detected in 54 patients (31.6%). In patients having ND-CLM, the number of tumor was larger (P=0.0158) and the level of CEA was higher (P=0.0035) than in those without ND-CLM. Operative procedures were modified intraoperatively because of detection of ND-CLM in 23 patients (42.6 %). However , ND-CLM did not preclude curative resection in any patients. The 5-year recurrence-free (RFS) and overall survival (OS) rates in patients with ND-CLM (28.1% and 29.0%) were worse than those without ND-CLM (39.5% [p= 0.0079], 58.1% [p =0.0010]). In multivariate analysis, having ND-CLM was found to be an independent risk factor of impaired RFS (hazard ratio =1.81, p =0.0385) and OS (hazard ratio =2.06, p =0.0165 ). Conclusions: Detection of new lesions during hepatectomy negatively impacts on survival in patients undergoing surgery for colorectal liver metastases." @default.
- W2894962968 created "2018-10-12" @default.
- W2894962968 creator A5027352757 @default.
- W2894962968 date "2018-09-01" @default.
- W2894962968 modified "2023-10-14" @default.
- W2894962968 title "Clinical significance of colorectal liver metastases newly detected during hepatectomy" @default.
- W2894962968 doi "https://doi.org/10.1016/j.hpb.2018.06.2603" @default.
- W2894962968 hasPublicationYear "2018" @default.
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