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- W2894964386 abstract "We congratulate both Michael Friedlander and colleagues 1 Friedlander M Gebski V Gibbs E et al. Health-related quality of life and patient-centred outcomes with olaparib maintenance after chemotherapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT Ov-21): a placebo-controlled, phase 3 randomised trial. Lancet Oncol. 2018; 19: 1126-1134 Summary Full Text Full Text PDF PubMed Scopus (96) Google Scholar and Amit Oza and colleagues 2 Oza AM Matulonis UA Malander S et al. Quality of life in patients with recurrent ovarian cancer treated with niraparib versus placebo (ENGOT-OV16/NOVA): results from a double-blind, phase 3, randomised controlled trial. Lancet Oncol. 2018; 19: 1117-1125 Summary Full Text Full Text PDF PubMed Scopus (66) Google Scholar on two rigorous, large-scale investigations of patient-reported quality-of-life (QOL) metrics from the SOLO2 and NOVA studies. Their findings raise further questions regarding the most appropriate endpoints for assessing maintenance therapy for platinum-sensitive recurrent ovarian cancer. Health-related quality of life and patient-centred outcomes with olaparib maintenance after chemotherapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT Ov-21): a placebo-controlled, phase 3 randomised trialOlaparib maintenance therapy did not have a significant detrimental effect on HRQOL compared with placebo. There were clinically meaningful patient-centred benefits in both TWiST and QAPFS despite the adverse effects associated with olaparib. These patient-centred endpoints support the improvement in progression-free survival, the primary endpoint in SOLO2, and should be included in future trials of maintenance therapies. Full-Text PDF" @default.
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- W2894964386 date "2018-10-01" @default.
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- W2894964386 title "Maintenance PARP inhibitor therapy: is maintaining quality of life enough?" @default.
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- W2894964386 doi "https://doi.org/10.1016/s1470-2045(18)30623-5" @default.
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