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- W2894964423 abstract "The mammalian immune system relies on recognition of pathogen surface antigens for targeting and clearance. In the absence of immune evasion strategies, pathogen clearance is rapid. In the case of Aspergillus fumigatus , the successful fungus must avoid phagocytosis in the lung to establish invasive infection. In healthy individuals, fungal spores are cleared by immune cells; however, in immunocompromised patients, clearance mechanisms are impaired. Here, using proteome analyses, we identified CcpA as an important fungal spore protein involved in pathogenesis. A. fumigatus lacking CcpA was more susceptible to immune recognition and prompt eradication and, consequently, exhibited drastically attenuated virulence. In infection studies, CcpA was required for virulence in infected immunocompromised mice, suggesting that it could be used as a possible immunotherapeutic or diagnostic target in the future. In summary, our report adds a protein to the list of those known to be critical to the complex fungal spore surface environment and, more importantly, identifies a protein important for conidial immunogenicity during infection." @default.
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- W2894964423 date "2018-11-07" @default.
- W2894964423 modified "2023-10-17" @default.
- W2894964423 title "Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus<i>Aspergillus fumigatus</i>" @default.
- W2894964423 cites W1572283658 @default.
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- W2894964423 cites W1623643996 @default.
- W2894964423 cites W1750025028 @default.
- W2894964423 cites W1839977438 @default.
- W2894964423 cites W1847147479 @default.
- W2894964423 cites W1887296783 @default.
- W2894964423 cites W1934775191 @default.
- W2894964423 cites W1973060279 @default.
- W2894964423 cites W1973988376 @default.
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- W2894964423 cites W1978542424 @default.
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- W2894964423 cites W2058522802 @default.
- W2894964423 cites W2061789597 @default.
- W2894964423 cites W2062946300 @default.
- W2894964423 cites W2066110878 @default.
- W2894964423 cites W2078893340 @default.
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- W2894964423 cites W2085310880 @default.
- W2894964423 cites W2094201044 @default.
- W2894964423 cites W2095779036 @default.
- W2894964423 cites W2097216675 @default.
- W2894964423 cites W2097372776 @default.
- W2894964423 cites W2099170652 @default.
- W2894964423 cites W2099176294 @default.
- W2894964423 cites W2100544695 @default.
- W2894964423 cites W2102763929 @default.
- W2894964423 cites W2104800550 @default.
- W2894964423 cites W2106246537 @default.
- W2894964423 cites W2107794472 @default.
- W2894964423 cites W2110965354 @default.
- W2894964423 cites W2114029795 @default.
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- W2894964423 cites W2124814621 @default.
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- W2894964423 cites W2138253605 @default.
- W2894964423 cites W2141844009 @default.
- W2894964423 cites W2143055461 @default.
- W2894964423 cites W2146377737 @default.
- W2894964423 cites W2146476031 @default.
- W2894964423 cites W2146646005 @default.
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- W2894964423 cites W2149051930 @default.
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- W2894964423 doi "https://doi.org/10.1128/mbio.01557-18" @default.
- W2894964423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168859" @default.
- W2894964423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279286" @default.
- W2894964423 hasPublicationYear "2018" @default.
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