Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894966767> ?p ?o ?g. }
- W2894966767 abstract "Abstract Oxidative stress in retinal pigment epithelium (RPE) is considered to be a major contributor to the development and progression of age-related macular degeneration (AMD). Previous investigations have shown that sodium tanshinone IIA sulfonate (STS) can alleviate oxidative stress in haemorrhagic shock-induced organ damage and cigarette smoke-induced chronic obstructive pulmonary disease in mice. However, whether STS has a protective effect in ARPE-19 cells under oxidative stress and its exact mechanisms have not yet been fully elucidated. In the present study, we utilized H 2 O 2 to establish an oxidative stress environment. Our findings show that STS activated the PI3K/AKT/mTOR pathway to inhibit autophagy and diminished the expression of the autophagic proteins Beclin 1, ATG3, ATG7 and ATG9 in ARPE-19 cells under oxidative stress. Detection of the intrinsic apoptosis-related factors BAX, mitochondrial membrane potential (MMP), caspase-9, caspase-3 and BCL-2, as well as the extrinsic apoptosis-related factors c-FLIP, v-FLIP and caspase-8, confirmed that STS inhibited the intrinsic and extrinsic apoptotic pathways, and attenuated apoptosis in ARPE-19 cells under oxidative stress conditions. These findings shed new light on the protective effects of STS in ARPE-19 cells and its mechanisms under oxidative stress to provide novel and promising therapeutic strategies for AMD." @default.
- W2894966767 created "2018-10-12" @default.
- W2894966767 creator A5014898290 @default.
- W2894966767 creator A5020119257 @default.
- W2894966767 creator A5022065654 @default.
- W2894966767 creator A5044784619 @default.
- W2894966767 creator A5053987355 @default.
- W2894966767 date "2018-10-11" @default.
- W2894966767 modified "2023-10-01" @default.
- W2894966767 title "Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis" @default.
- W2894966767 cites W1523693806 @default.
- W2894966767 cites W1665583843 @default.
- W2894966767 cites W1978981032 @default.
- W2894966767 cites W1980078856 @default.
- W2894966767 cites W1980792888 @default.
- W2894966767 cites W1981711832 @default.
- W2894966767 cites W1983649388 @default.
- W2894966767 cites W1987526360 @default.
- W2894966767 cites W1992894966 @default.
- W2894966767 cites W1998354357 @default.
- W2894966767 cites W2001745503 @default.
- W2894966767 cites W2007318225 @default.
- W2894966767 cites W2008649656 @default.
- W2894966767 cites W2014918593 @default.
- W2894966767 cites W2017728303 @default.
- W2894966767 cites W2021051229 @default.
- W2894966767 cites W2021814263 @default.
- W2894966767 cites W2022675211 @default.
- W2894966767 cites W2026531128 @default.
- W2894966767 cites W2027482010 @default.
- W2894966767 cites W2031281657 @default.
- W2894966767 cites W2032417513 @default.
- W2894966767 cites W2037334479 @default.
- W2894966767 cites W2038870226 @default.
- W2894966767 cites W2039531276 @default.
- W2894966767 cites W2045457634 @default.
- W2894966767 cites W2049727981 @default.
- W2894966767 cites W2052550497 @default.
- W2894966767 cites W2053281570 @default.
- W2894966767 cites W2057274775 @default.
- W2894966767 cites W2057530007 @default.
- W2894966767 cites W2058906042 @default.
- W2894966767 cites W2061449630 @default.
- W2894966767 cites W2062195516 @default.
- W2894966767 cites W2062544109 @default.
- W2894966767 cites W2066571367 @default.
- W2894966767 cites W2073226327 @default.
- W2894966767 cites W2077929218 @default.
- W2894966767 cites W2084665273 @default.
- W2894966767 cites W2085822109 @default.
- W2894966767 cites W2091689157 @default.
- W2894966767 cites W2092787487 @default.
- W2894966767 cites W2095026873 @default.
- W2894966767 cites W2096308078 @default.
- W2894966767 cites W2099297532 @default.
- W2894966767 cites W2106279075 @default.
- W2894966767 cites W2108198510 @default.
- W2894966767 cites W2113432343 @default.
- W2894966767 cites W2114918609 @default.
- W2894966767 cites W2118274840 @default.
- W2894966767 cites W2129325060 @default.
- W2894966767 cites W2134735862 @default.
- W2894966767 cites W2141432835 @default.
- W2894966767 cites W2142432153 @default.
- W2894966767 cites W2146124002 @default.
- W2894966767 cites W2157053804 @default.
- W2894966767 cites W2157232189 @default.
- W2894966767 cites W2166550315 @default.
- W2894966767 cites W2167656141 @default.
- W2894966767 cites W2169683751 @default.
- W2894966767 cites W2290984819 @default.
- W2894966767 cites W2315925646 @default.
- W2894966767 cites W2471023808 @default.
- W2894966767 cites W2522464760 @default.
- W2894966767 cites W2534397029 @default.
- W2894966767 cites W2570744729 @default.
- W2894966767 cites W2606560811 @default.
- W2894966767 cites W2729258135 @default.
- W2894966767 cites W2738996050 @default.
- W2894966767 cites W2743254891 @default.
- W2894966767 cites W2802143380 @default.
- W2894966767 doi "https://doi.org/10.1038/s41598-018-33552-2" @default.
- W2894966767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181947" @default.
- W2894966767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310136" @default.
- W2894966767 hasPublicationYear "2018" @default.
- W2894966767 type Work @default.
- W2894966767 sameAs 2894966767 @default.
- W2894966767 citedByCount "34" @default.
- W2894966767 countsByYear W28949667672019 @default.
- W2894966767 countsByYear W28949667672020 @default.
- W2894966767 countsByYear W28949667672021 @default.
- W2894966767 countsByYear W28949667672022 @default.
- W2894966767 countsByYear W28949667672023 @default.
- W2894966767 crossrefType "journal-article" @default.
- W2894966767 hasAuthorship W2894966767A5014898290 @default.
- W2894966767 hasAuthorship W2894966767A5020119257 @default.
- W2894966767 hasAuthorship W2894966767A5022065654 @default.
- W2894966767 hasAuthorship W2894966767A5044784619 @default.
- W2894966767 hasAuthorship W2894966767A5053987355 @default.
- W2894966767 hasBestOaLocation W28949667671 @default.