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• W2894970130 abstract "Summary Background Platelet‐rich plasma (PRP) is a blood fraction that contains high concentrations of several growth factors. PRP has been recently used in skin wound healing and rejuvenation. However, the precise molecular mechanisms underlying PRP‐induced wound healing are unknown. Aims This study aimed to evaluate the effects of PRP on extracellular matrix remodeling, which requires the activation of dermal fibroblasts. Methods Cell proliferation and migration assay, enzyme‐linked immunosorbent analysis, and Western blotting were performed on PRP‐treated human skin fibroblasts. Results Platelet numbers were enhanced by 4.6‐fold in PRP compared to that in whole blood. PRP stimulated the proliferation and migration of human dermal fibroblasts and increased the expression of human procollagen I alpha 1, elastin, MMP‐1, and MMP‐2 in human dermal fibroblasts. PRP‐treated human dermal fibroblasts also showed a dramatic reduction in the phosphorylation of c‐Jun N‐terminal kinase (JNK), whereas total JNK levels were not significantly reduced. Conclusions Collectively, PRP induced increased expression of type I collagen, elastin, MMP‐1, and MMP‐2, thereby accelerating wound healing. Our findings reveal basic mechanisms underlying PRP‐mediated tissue remodeling. Thus, these results could be exploited for clinical dermatology and skin rejuvenation." @default.
• W2894970130 created "2018-10-12" @default.
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• W2894970130 date "2018-10-02" @default.
• W2894970130 modified "2023-09-30" @default.
• W2894970130 title "Effect of platelet-rich plasma on proliferation and migration in human dermal fibroblasts" @default.
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• W2894970130 doi "https://doi.org/10.1111/jocd.12780" @default.
• W2894970130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30280483" @default.
• W2894970130 hasPublicationYear "2018" @default.
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