Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894970588> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2894970588 endingPage "774" @default.
- W2894970588 startingPage "770" @default.
- W2894970588 abstract "Materials from prefilled syringe systems—such as silicone oil, tungsten, glass, and rubber—may enhance therapeutic protein aggregation and particle formation. Also, the sterilization method used for syringes may impact aggregation and chemical degradation of biologics during storage. Syringes are generally sterilized by radiation, ethylene oxide gas (EO), or steam. Among the sterilization methods, EO has the potential to cause chemical degradation by the formation of adducts with susceptible amino acid residues in the protein. In this study, EO- and steam-sterilized syringes were compared to determine the influence of residual EO on human serum albumin (HSA) degradation. Although the amount of residual EO in the EO-sterilized syringes was less than 220 μg/syringe, well below the International Organization for Standardization limit, EO adduction to cysteine (Cys) and methionine (Met) in HSA was observed by liquid chromatography and mass spectrometry analysis. The EO adduct ratio of HSA stored for 2 weeks in EO-sterilized syringes was about 45%. In contrast, no chemical degradation was observed in HSA formulation stored in steam-sterilized syringes. Because of the propensity of EO to readily form adducts with proteins, an alternative to EO sterilization should be used for prefilled syringes that will be used for therapeutic protein products." @default.
- W2894970588 created "2018-10-12" @default.
- W2894970588 creator A5007336944 @default.
- W2894970588 creator A5008365437 @default.
- W2894970588 creator A5020624921 @default.
- W2894970588 creator A5043479194 @default.
- W2894970588 date "2019-01-01" @default.
- W2894970588 modified "2023-09-29" @default.
- W2894970588 title "Impact of Ethylene Oxide Sterilization of Polymer-Based Prefilled Syringes on Chemical Degradation of a Model Therapeutic Protein During Storage" @default.
- W2894970588 cites W1973238993 @default.
- W2894970588 cites W1974795397 @default.
- W2894970588 cites W1975064844 @default.
- W2894970588 cites W1997813339 @default.
- W2894970588 cites W2009466077 @default.
- W2894970588 cites W2010612735 @default.
- W2894970588 cites W2027397388 @default.
- W2894970588 cites W2034455355 @default.
- W2894970588 cites W2036630607 @default.
- W2894970588 cites W2040218030 @default.
- W2894970588 cites W2047125616 @default.
- W2894970588 cites W2048950025 @default.
- W2894970588 cites W2056085522 @default.
- W2894970588 cites W2078172351 @default.
- W2894970588 cites W2090305399 @default.
- W2894970588 cites W2093929400 @default.
- W2894970588 cites W2106357609 @default.
- W2894970588 cites W2129365134 @default.
- W2894970588 cites W2152604288 @default.
- W2894970588 cites W2567601831 @default.
- W2894970588 cites W2590725655 @default.
- W2894970588 cites W4240939053 @default.
- W2894970588 doi "https://doi.org/10.1016/j.xphs.2018.09.029" @default.
- W2894970588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296419" @default.
- W2894970588 hasPublicationYear "2019" @default.
- W2894970588 type Work @default.
- W2894970588 sameAs 2894970588 @default.
- W2894970588 citedByCount "20" @default.
- W2894970588 countsByYear W28949705882019 @default.
- W2894970588 countsByYear W28949705882020 @default.
- W2894970588 countsByYear W28949705882021 @default.
- W2894970588 countsByYear W28949705882022 @default.
- W2894970588 countsByYear W28949705882023 @default.
- W2894970588 crossrefType "journal-article" @default.
- W2894970588 hasAuthorship W2894970588A5007336944 @default.
- W2894970588 hasAuthorship W2894970588A5008365437 @default.
- W2894970588 hasAuthorship W2894970588A5020624921 @default.
- W2894970588 hasAuthorship W2894970588A5043479194 @default.
- W2894970588 hasConcept C148761745 @default.
- W2894970588 hasConcept C15920480 @default.
- W2894970588 hasConcept C162324750 @default.
- W2894970588 hasConcept C178790620 @default.
- W2894970588 hasConcept C185592680 @default.
- W2894970588 hasConcept C2777801237 @default.
- W2894970588 hasConcept C2983132609 @default.
- W2894970588 hasConcept C43617362 @default.
- W2894970588 hasConcept C521977710 @default.
- W2894970588 hasConcept C536366893 @default.
- W2894970588 hasConcept C556758197 @default.
- W2894970588 hasConceptScore W2894970588C148761745 @default.
- W2894970588 hasConceptScore W2894970588C15920480 @default.
- W2894970588 hasConceptScore W2894970588C162324750 @default.
- W2894970588 hasConceptScore W2894970588C178790620 @default.
- W2894970588 hasConceptScore W2894970588C185592680 @default.
- W2894970588 hasConceptScore W2894970588C2777801237 @default.
- W2894970588 hasConceptScore W2894970588C2983132609 @default.
- W2894970588 hasConceptScore W2894970588C43617362 @default.
- W2894970588 hasConceptScore W2894970588C521977710 @default.
- W2894970588 hasConceptScore W2894970588C536366893 @default.
- W2894970588 hasConceptScore W2894970588C556758197 @default.
- W2894970588 hasIssue "1" @default.
- W2894970588 hasLocation W28949705881 @default.
- W2894970588 hasLocation W28949705882 @default.
- W2894970588 hasOpenAccess W2894970588 @default.
- W2894970588 hasPrimaryLocation W28949705881 @default.
- W2894970588 hasRelatedWork W2008037122 @default.
- W2894970588 hasRelatedWork W2117555936 @default.
- W2894970588 hasRelatedWork W2142468530 @default.
- W2894970588 hasRelatedWork W2202178620 @default.
- W2894970588 hasRelatedWork W2308687553 @default.
- W2894970588 hasRelatedWork W2417074060 @default.
- W2894970588 hasRelatedWork W2464398706 @default.
- W2894970588 hasRelatedWork W251757747 @default.
- W2894970588 hasRelatedWork W2589038762 @default.
- W2894970588 hasRelatedWork W3081191028 @default.
- W2894970588 hasVolume "108" @default.
- W2894970588 isParatext "false" @default.
- W2894970588 isRetracted "false" @default.
- W2894970588 magId "2894970588" @default.
- W2894970588 workType "article" @default.