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• W2894971993 abstract "Abstract Objectives Infections are a major cause of mortality after allogeneic haemopoietic stem cell transplantation (allo HSCT ), and immune recovery is necessary for prevention. Novel transplant procedures have changed the epidemiology of infections but contemporary data on functional immune recovery are limited. In this pilot study, we aimed to measure immune recovery in the current era of allo HSCT . Methods Twenty, 13, 11, 9 and 9 allo HSCT recipients had blood collected at baseline (time of conditioning) and 3‐, 6‐, 9‐, and 12‐months post‐allo HSCT , respectively. Clinical data were collected, and immune recovery was measured using immunophenotyping, lymphocyte proliferation, cytokine analysis and antibody isotyping. Results Median absolute T‐ and B‐cell counts were below normal from baseline until 9‐ to 12‐months post‐allo HSCT . Median absolute CD 4 + T‐cell counts recovered at 12‐months post‐allo HSCT . Positive proliferative responses to Aspergillus , cytomegalovirus ( CMV ), Epstein‐Barr virus ( EBV ), influenza and tetanus antigens were detected from 9 months. IL ‐6 was the most abundant cytokine in cell cultures. In cultures stimulated with CMV , EBV , influenza and tetanus peptides, the CD 4 + T‐cell count correlated with IL ‐1β ( P = 0.045) and CD 8 + T‐cell count with IFN γ ( P = 0.013) and IL ‐1β ( P = 0.012). The NK ‐cell count correlated with IL ‐1β ( P = 0.02) and IL ‐17a ( P = 0.03). Median serum levels of IgG1, IgG2 and IgG3 were normal while IgG4 and IgA were below normal range throughout follow‐up. Conclusions This pilot study demonstrates that immune recovery can be measured using CD 4 + T‐cell counts, in vitro antigen stimulation and selected cytokines ( IFN γ, IL ‐1β, IL ‐4, IL ‐6, IL ‐17, IL ‐21, IL ‐31) in allo HSCT recipients. While larger studies are required, monitoring immune recovery may have utility in predicting infection risk post‐allo HSCT ." @default.
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• W2894971993 date "2018-01-01" @default.
• W2894971993 modified "2023-10-14" @default.
• W2894971993 title "Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation" @default.
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• W2894971993 doi "https://doi.org/10.1002/cti2.1040" @default.
• W2894971993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173278" @default.
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