FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894972298> ?p ?o ?g. }

• W2894972298 endingPage "476" @default.
• W2894972298 startingPage "470" @default.
• W2894972298 abstract "Introduction Detecting early cardiac involvement in Fabry disease (FD) is important because therapy may alter disease progression. Cardiovascular magnetic resonance (CMR) can detect T1 lowering, representing myocardial sphingolipid storage. In many diseases, early mechanical dysfunction may be detected by abnormal global longitudinal strain (GLS). We explored the relationship of early mechanical dysfunction and sphingolipid deposition in FD. Methods An observational study of 221 FD and 77 healthy volunteers (HVs) who underwent CMR (LV volumes, mass, native T1, GLS, late gadolinium enhancement), ECG and blood biomarkers, as part of the prospective multicentre Fabry400 study. Results All FD had normal LV ejection fraction (EF 73%±8%). Mean indexed LV mass (LVMi) was 89±39 g/m 2 in FD and 55.6±10 g/m 2 in HV. 102 (46%) FD participants had left ventricular hypertrophy (LVH). There was a negative correlation between GLS and native T1 in FD patients (r=−0.515, p<0.001). In FD patients without LVH (early disease), as native T1 reduced there was impairment in GLS (r=−0.285, p<0.002). In the total FD cohort, ECG abnormalities were associated with a significant impairment in GLS compared with those without ECG abnormalities (abnormal: −16.7±3.5 vs normal: −20.2±2.4, p<0.001). Conclusions GLS in FD correlates with an increase in LVMi, storage and the presence of ECG abnormalities. In LVH-negative FD (early disease), impairment in GLS is associated with a reduction in native T1, suggesting that mechanical dysfunction occurs before evidence of sphingolipid deposition (low T1). Trial registration number NCT03199001 ; Results." @default.
• W2894972298 created "2018-10-12" @default.
• W2894972298 creator A5000436427 @default.
• W2894972298 creator A5003474421 @default.
• W2894972298 creator A5004068647 @default.
• W2894972298 creator A5016812185 @default.
• W2894972298 creator A5018114109 @default.
• W2894972298 creator A5019087751 @default.
• W2894972298 creator A5037924600 @default.
• W2894972298 creator A5039193038 @default.
• W2894972298 creator A5041855321 @default.
• W2894972298 creator A5044379924 @default.
• W2894972298 creator A5048870331 @default.
• W2894972298 creator A5056641479 @default.
• W2894972298 date "2018-10-03" @default.
• W2894972298 modified "2023-10-14" @default.
• W2894972298 title "Global longitudinal strain, myocardial storage and hypertrophy in Fabry disease" @default.
• W2894972298 cites W141162516 @default.
• W2894972298 cites W1979923416 @default.
• W2894972298 cites W2040300304 @default.
• W2894972298 cites W2043774580 @default.
• W2894972298 cites W2044012755 @default.
• W2894972298 cites W2047137134 @default.
• W2894972298 cites W2053448748 @default.
• W2894972298 cites W2070950963 @default.
• W2894972298 cites W2077540830 @default.
• W2894972298 cites W2094976188 @default.
• W2894972298 cites W2117828918 @default.
• W2894972298 cites W2118862442 @default.
• W2894972298 cites W2134159563 @default.
• W2894972298 cites W2136811556 @default.
• W2894972298 cites W2139586681 @default.
• W2894972298 cites W2146877343 @default.
• W2894972298 cites W2157815735 @default.
• W2894972298 cites W2158457377 @default.
• W2894972298 cites W2171618818 @default.
• W2894972298 cites W2465757865 @default.
• W2894972298 cites W2528107840 @default.
• W2894972298 cites W2547304805 @default.
• W2894972298 cites W2547410059 @default.
• W2894972298 cites W2803823282 @default.
• W2894972298 cites W2806403173 @default.
• W2894972298 cites W56741857 @default.
• W2894972298 doi "https://doi.org/10.1136/heartjnl-2018-313699" @default.
• W2894972298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282640" @default.
• W2894972298 hasPublicationYear "2018" @default.
• W2894972298 type Work @default.
• W2894972298 sameAs 2894972298 @default.
• W2894972298 citedByCount "41" @default.
• W2894972298 countsByYear W28949722982019 @default.
• W2894972298 countsByYear W28949722982020 @default.
• W2894972298 countsByYear W28949722982021 @default.
• W2894972298 countsByYear W28949722982022 @default.
• W2894972298 countsByYear W28949722982023 @default.
• W2894972298 crossrefType "journal-article" @default.
• W2894972298 hasAuthorship W2894972298A5000436427 @default.
• W2894972298 hasAuthorship W2894972298A5003474421 @default.
• W2894972298 hasAuthorship W2894972298A5004068647 @default.
• W2894972298 hasAuthorship W2894972298A5016812185 @default.
• W2894972298 hasAuthorship W2894972298A5018114109 @default.
• W2894972298 hasAuthorship W2894972298A5019087751 @default.
• W2894972298 hasAuthorship W2894972298A5037924600 @default.
• W2894972298 hasAuthorship W2894972298A5039193038 @default.
• W2894972298 hasAuthorship W2894972298A5041855321 @default.
• W2894972298 hasAuthorship W2894972298A5044379924 @default.
• W2894972298 hasAuthorship W2894972298A5048870331 @default.
• W2894972298 hasAuthorship W2894972298A5056641479 @default.
• W2894972298 hasBestOaLocation W28949722982 @default.
• W2894972298 hasConcept C126322002 @default.
• W2894972298 hasConcept C126838900 @default.
• W2894972298 hasConcept C143409427 @default.
• W2894972298 hasConcept C164705383 @default.
• W2894972298 hasConcept C185592680 @default.
• W2894972298 hasConcept C188816634 @default.
• W2894972298 hasConcept C2776002628 @default.
• W2894972298 hasConcept C2777404818 @default.
• W2894972298 hasConcept C2778198053 @default.
• W2894972298 hasConcept C2779134260 @default.
• W2894972298 hasConcept C55493867 @default.
• W2894972298 hasConcept C61705674 @default.
• W2894972298 hasConcept C71924100 @default.
• W2894972298 hasConcept C78085059 @default.
• W2894972298 hasConcept C84393581 @default.
• W2894972298 hasConceptScore W2894972298C126322002 @default.
• W2894972298 hasConceptScore W2894972298C126838900 @default.
• W2894972298 hasConceptScore W2894972298C143409427 @default.
• W2894972298 hasConceptScore W2894972298C164705383 @default.
• W2894972298 hasConceptScore W2894972298C185592680 @default.
• W2894972298 hasConceptScore W2894972298C188816634 @default.
• W2894972298 hasConceptScore W2894972298C2776002628 @default.
• W2894972298 hasConceptScore W2894972298C2777404818 @default.
• W2894972298 hasConceptScore W2894972298C2778198053 @default.
• W2894972298 hasConceptScore W2894972298C2779134260 @default.
• W2894972298 hasConceptScore W2894972298C55493867 @default.
• W2894972298 hasConceptScore W2894972298C61705674 @default.
• W2894972298 hasConceptScore W2894972298C71924100 @default.
• W2894972298 hasConceptScore W2894972298C78085059 @default.
• W2894972298 hasConceptScore W2894972298C84393581 @default.

• next