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• W2894975317 abstract "Osteoporotic hip fractures are a major healthcare problem. Fall severity and bone strength are important risk factors of hip fracture. This study aims to obtain a mechanistic explanation for fracture risk in dependence of these risk factors. A novel modelling approach is developed that combines models at different scales to overcome the challenge of a large space–time domain of interest and considers the variability of impact forces between potential falls in a subject. The multiscale model and its component models are verified with respect to numerical approximations made therein, the propagation of measurement uncertainties of model inputs is quantified, and model predictions are validated against experimental and clinical data. The main results are model predicted absolute risk of current fracture (ARF0) that ranged from 1.93 to 81.6% (median 36.1%) for subjects in a retrospective cohort of 98 postmenopausal British women (49 fracture cases and 49 controls); ARF0 was computed up to a precision of 1.92 percentage points (pp) due to numerical approximations made in the model; ARF0 possessed an uncertainty of 4.00 pp due to uncertainties in measuring model inputs; ARF0 classified observed fracture status in the above cohort with AUC = 0.852 (95% CI 0.753–0.918), 77.6% specificity (95% CI 63.4–86.5%) and 81.6% sensitivity (95% CI 68.3–91.1%). These results demonstrate that ARF0 can be computed using the model with sufficient precision to distinguish between subjects and that the novel mechanism of fracture risk determination based on fall dynamics, hip impact and bone strength can be considered validated." @default.
• W2894975317 created "2018-10-12" @default.
• W2894975317 creator A5016868374 @default.
• W2894975317 creator A5040799533 @default.
• W2894975317 creator A5065603635 @default.
• W2894975317 creator A5086585880 @default.
• W2894975317 date "2018-10-01" @default.
• W2894975317 modified "2023-10-17" @default.
• W2894975317 title "A multiscale model to predict current absolute risk of femoral fracture in a postmenopausal population" @default.
• W2894975317 cites W1639111335 @default.
• W2894975317 cites W1964678256 @default.
• W2894975317 cites W1966356042 @default.
• W2894975317 cites W1967372102 @default.
• W2894975317 cites W1968092726 @default.
• W2894975317 cites W1968106150 @default.
• W2894975317 cites W1970144926 @default.
• W2894975317 cites W1971257860 @default.
• W2894975317 cites W1973823819 @default.
• W2894975317 cites W1974356581 @default.
• W2894975317 cites W1974995152 @default.
• W2894975317 cites W1993071811 @default.
• W2894975317 cites W1994486302 @default.
• W2894975317 cites W1994665973 @default.
• W2894975317 cites W1995079442 @default.
• W2894975317 cites W2003040980 @default.
• W2894975317 cites W2007752694 @default.
• W2894975317 cites W2009423512 @default.
• W2894975317 cites W2011085754 @default.
• W2894975317 cites W2011272591 @default.
• W2894975317 cites W2016253728 @default.
• W2894975317 cites W2024738955 @default.
• W2894975317 cites W2025454892 @default.
• W2894975317 cites W2039180833 @default.
• W2894975317 cites W2044064269 @default.
• W2894975317 cites W2052674680 @default.
• W2894975317 cites W2053848693 @default.
• W2894975317 cites W2060452535 @default.
• W2894975317 cites W2060868033 @default.
• W2894975317 cites W2068360652 @default.
• W2894975317 cites W2069165386 @default.
• W2894975317 cites W2069249122 @default.
• W2894975317 cites W2070347155 @default.
• W2894975317 cites W2074720757 @default.
• W2894975317 cites W2076349714 @default.
• W2894975317 cites W2076505399 @default.
• W2894975317 cites W2078515578 @default.
• W2894975317 cites W2079803459 @default.
• W2894975317 cites W2088765131 @default.
• W2894975317 cites W2089968363 @default.
• W2894975317 cites W2090510711 @default.
• W2894975317 cites W2093948624 @default.
• W2894975317 cites W2094052195 @default.
• W2894975317 cites W2098024368 @default.
• W2894975317 cites W2098089601 @default.
• W2894975317 cites W2100541425 @default.
• W2894975317 cites W2101076802 @default.
• W2894975317 cites W2101133451 @default.
• W2894975317 cites W2101589741 @default.
• W2894975317 cites W2103977226 @default.
• W2894975317 cites W2104080379 @default.
• W2894975317 cites W2106504381 @default.
• W2894975317 cites W2110768118 @default.
• W2894975317 cites W2112964941 @default.
• W2894975317 cites W2115701998 @default.
• W2894975317 cites W2118856586 @default.
• W2894975317 cites W2130382852 @default.
• W2894975317 cites W2133140997 @default.
• W2894975317 cites W2144687515 @default.
• W2894975317 cites W2146023819 @default.
• W2894975317 cites W2148225539 @default.
• W2894975317 cites W2150014095 @default.
• W2894975317 cites W2151809311 @default.
• W2894975317 cites W2161087332 @default.
• W2894975317 cites W2169559303 @default.
• W2894975317 cites W2178531585 @default.
• W2894975317 cites W2323830513 @default.
• W2894975317 cites W2326354310 @default.
• W2894975317 cites W2339157188 @default.
• W2894975317 cites W2416259076 @default.
• W2894975317 cites W2485809636 @default.
• W2894975317 cites W2573307697 @default.
• W2894975317 cites W2616305484 @default.
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• W2894975317 doi "https://doi.org/10.1007/s10237-018-1081-0" @default.
• W2894975317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6418062" @default.
• W2894975317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30276488" @default.
• W2894975317 hasPublicationYear "2018" @default.
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