FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894977023> ?p ?o ?g. }

• W2894977023 endingPage "846" @default.
• W2894977023 startingPage "835" @default.
• W2894977023 abstract "Hemophilia is a serious bleeding disorder characterized by repeated bleeding episodes into joints and muscles which can lead to permanent disabilities. Treatment with factor replacement therapy has proven to be effective at preventing these complications; however, it can lead to formation of neutralizing antibodies termed inhibitors which significantly complicate the management of the disorder. These inhibitor patients suffer from increased morbidity and mortality and there has been a major unmet need for novel therapeutic approaches. Recently, one such therapy, emicizumab, has been licensed in the United States. Areas covered: This manuscript contains a detailed discussion of the mechanism of action, the clinical trial development program as well as a review of the benefits and risks of this novel agent. In addition, practical considerations for the use of the agent are also described. Expert commentary: Emicizumab represents a new class of medication for the treatment of hemophilia A which in the past has relied on factor replacement therapy and bypassing agent (alternative factor) therapy. Emicizumab fulfills two major unmet needs in patients with hemophilia who have FVIII inhibitors. First, it provides for a much more effective therapy for the prevention of bleeding and second it substantially reduces the treatment burden." @default.
• W2894977023 created "2018-10-12" @default.
• W2894977023 creator A5000917771 @default.
• W2894977023 creator A5004338432 @default.
• W2894977023 creator A5020488137 @default.
• W2894977023 creator A5051210012 @default.
• W2894977023 creator A5086373140 @default.
• W2894977023 date "2018-10-10" @default.
• W2894977023 modified "2023-09-27" @default.
• W2894977023 title "Emicizumab for hemophilia A with factor VIII inhibitors" @default.
• W2894977023 cites W1483948734 @default.
• W2894977023 cites W1548860147 @default.
• W2894977023 cites W1595975852 @default.
• W2894977023 cites W1921219324 @default.
• W2894977023 cites W1953131135 @default.
• W2894977023 cites W1964262283 @default.
• W2894977023 cites W1967890046 @default.
• W2894977023 cites W1968924601 @default.
• W2894977023 cites W1969419914 @default.
• W2894977023 cites W1974712886 @default.
• W2894977023 cites W1996687083 @default.
• W2894977023 cites W2004324995 @default.
• W2894977023 cites W2019570266 @default.
• W2894977023 cites W2023810744 @default.
• W2894977023 cites W2026336161 @default.
• W2894977023 cites W2026502021 @default.
• W2894977023 cites W2028940468 @default.
• W2894977023 cites W2048097015 @default.
• W2894977023 cites W2072864431 @default.
• W2894977023 cites W2086294372 @default.
• W2894977023 cites W2095243830 @default.
• W2894977023 cites W2095583634 @default.
• W2894977023 cites W2098827747 @default.
• W2894977023 cites W2108014527 @default.
• W2894977023 cites W2111944942 @default.
• W2894977023 cites W2123107121 @default.
• W2894977023 cites W2126034895 @default.
• W2894977023 cites W2147887043 @default.
• W2894977023 cites W2163909723 @default.
• W2894977023 cites W2172269466 @default.
• W2894977023 cites W2318818609 @default.
• W2894977023 cites W2400928773 @default.
• W2894977023 cites W2401865216 @default.
• W2894977023 cites W2417605240 @default.
• W2894977023 cites W2518847837 @default.
• W2894977023 cites W2557234475 @default.
• W2894977023 cites W2571285521 @default.
• W2894977023 cites W2612497493 @default.
• W2894977023 cites W2621252057 @default.
• W2894977023 cites W2734287351 @default.
• W2894977023 cites W2744486571 @default.
• W2894977023 cites W2760006373 @default.
• W2894977023 cites W2765948748 @default.
• W2894977023 cites W2766647089 @default.
• W2894977023 cites W2766748635 @default.
• W2894977023 cites W2789183584 @default.
• W2894977023 cites W2793763904 @default.
• W2894977023 cites W2888898681 @default.
• W2894977023 cites W2966634303 @default.
• W2894977023 cites W3015502221 @default.
• W2894977023 doi "https://doi.org/10.1080/17474086.2018.1531701" @default.
• W2894977023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278802" @default.
• W2894977023 hasPublicationYear "2018" @default.
• W2894977023 type Work @default.
• W2894977023 sameAs 2894977023 @default.
• W2894977023 citedByCount "17" @default.
• W2894977023 countsByYear W28949770232018 @default.
• W2894977023 countsByYear W28949770232019 @default.
• W2894977023 countsByYear W28949770232020 @default.
• W2894977023 countsByYear W28949770232021 @default.
• W2894977023 countsByYear W28949770232022 @default.
• W2894977023 countsByYear W28949770232023 @default.
• W2894977023 crossrefType "journal-article" @default.
• W2894977023 hasAuthorship W2894977023A5000917771 @default.
• W2894977023 hasAuthorship W2894977023A5004338432 @default.
• W2894977023 hasAuthorship W2894977023A5020488137 @default.
• W2894977023 hasAuthorship W2894977023A5051210012 @default.
• W2894977023 hasAuthorship W2894977023A5086373140 @default.
• W2894977023 hasConcept C126322002 @default.
• W2894977023 hasConcept C177713679 @default.
• W2894977023 hasConcept C2781221834 @default.
• W2894977023 hasConcept C535046627 @default.
• W2894977023 hasConcept C71924100 @default.
• W2894977023 hasConceptScore W2894977023C126322002 @default.
• W2894977023 hasConceptScore W2894977023C177713679 @default.
• W2894977023 hasConceptScore W2894977023C2781221834 @default.
• W2894977023 hasConceptScore W2894977023C535046627 @default.
• W2894977023 hasConceptScore W2894977023C71924100 @default.
• W2894977023 hasIssue "11" @default.
• W2894977023 hasLocation W28949770231 @default.
• W2894977023 hasLocation W28949770232 @default.
• W2894977023 hasOpenAccess W2894977023 @default.
• W2894977023 hasPrimaryLocation W28949770231 @default.
• W2894977023 hasRelatedWork W1593328756 @default.
• W2894977023 hasRelatedWork W1974325897 @default.
• W2894977023 hasRelatedWork W2008247344 @default.
• W2894977023 hasRelatedWork W2032098698 @default.
• W2894977023 hasRelatedWork W2033604118 @default.

• next