Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894977741> ?p ?o ?g. }
- W2894977741 endingPage "39" @default.
- W2894977741 startingPage "39" @default.
- W2894977741 abstract "It is well accepted that treatment of chronic pain with morphine leads to μ opioid receptor (MOR) desensitization and the development of morphine tolerance. MOR activation by the selective peptide agonist, D-Ala2, N-MePhe4, Gly-ol]-enkephalin(DAMGO), leads to robust G protein receptor kinase activation, β-arrestin recruitment, and subsequent receptor endocytosis, which does not occur in an activation by morphine. However, MOR activation by morphine induces receptor desensitization, in a Protein kinase C (PKC) dependent manner. PKC inhibitors have been reported to decrease receptor desensitization, reduce opiate tolerance, and increase analgesia. However, the exact role of PKC in these processes is not clearly delineated. The difficulties in establishing a particular role for PKC have been, in part, due to the lack of reagents that allow the selective identification of PKC targets. Recently, we generated a conformation state-specific anti-PKC antibody that preferentially recognizes the active state of this kinase. Using this antibody to selectively isolate PKC substrates and a proteomics strategy to establish the identity of the proteins, we examined the effect of morphine treatment on the PKC targets. We found an enhanced interaction of a number of proteins with active PKC, in the presence of morphine. In this article, we discuss the role of these proteins in PKC-mediated MOR desensitization and analgesia. In addition, we posit a role for some of these proteins in mediating pain by TrKA activation, via the activation of transient receptor potential cation channel subfamily V member 1 (TRPV1). Finally, we discuss how these new PKC interacting proteins and pathways could be targeted for the treatment of pain." @default.
- W2894977741 created "2018-10-12" @default.
- W2894977741 creator A5013259171 @default.
- W2894977741 creator A5030975938 @default.
- W2894977741 creator A5053630827 @default.
- W2894977741 creator A5076635917 @default.
- W2894977741 creator A5084540545 @default.
- W2894977741 date "2018-10-06" @default.
- W2894977741 modified "2023-09-28" @default.
- W2894977741 title "Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA" @default.
- W2894977741 cites W1572716768 @default.
- W2894977741 cites W1605581154 @default.
- W2894977741 cites W1699017532 @default.
- W2894977741 cites W1864822730 @default.
- W2894977741 cites W1909195053 @default.
- W2894977741 cites W1968490749 @default.
- W2894977741 cites W1968901954 @default.
- W2894977741 cites W1974654730 @default.
- W2894977741 cites W1976307708 @default.
- W2894977741 cites W1978647461 @default.
- W2894977741 cites W1980701895 @default.
- W2894977741 cites W199111168 @default.
- W2894977741 cites W1993282564 @default.
- W2894977741 cites W1995705528 @default.
- W2894977741 cites W1996303646 @default.
- W2894977741 cites W2005957118 @default.
- W2894977741 cites W2007803807 @default.
- W2894977741 cites W2011092125 @default.
- W2894977741 cites W2025637729 @default.
- W2894977741 cites W2031811175 @default.
- W2894977741 cites W2034615670 @default.
- W2894977741 cites W2037083050 @default.
- W2894977741 cites W2039261279 @default.
- W2894977741 cites W2039548187 @default.
- W2894977741 cites W2040668587 @default.
- W2894977741 cites W2042603562 @default.
- W2894977741 cites W2043287085 @default.
- W2894977741 cites W2043834992 @default.
- W2894977741 cites W2054523068 @default.
- W2894977741 cites W2054883111 @default.
- W2894977741 cites W2055319462 @default.
- W2894977741 cites W2059524959 @default.
- W2894977741 cites W2061027645 @default.
- W2894977741 cites W2064374911 @default.
- W2894977741 cites W2071677901 @default.
- W2894977741 cites W2071817920 @default.
- W2894977741 cites W2075486656 @default.
- W2894977741 cites W2079712957 @default.
- W2894977741 cites W2088823687 @default.
- W2894977741 cites W2093989410 @default.
- W2894977741 cites W2101267046 @default.
- W2894977741 cites W2105080299 @default.
- W2894977741 cites W2106465386 @default.
- W2894977741 cites W2107277218 @default.
- W2894977741 cites W2108111134 @default.
- W2894977741 cites W2116147934 @default.
- W2894977741 cites W2125182431 @default.
- W2894977741 cites W2134555179 @default.
- W2894977741 cites W2137137048 @default.
- W2894977741 cites W2138158469 @default.
- W2894977741 cites W2142884223 @default.
- W2894977741 cites W2143153645 @default.
- W2894977741 cites W2153356592 @default.
- W2894977741 cites W2158519248 @default.
- W2894977741 cites W2161262899 @default.
- W2894977741 cites W2164207648 @default.
- W2894977741 cites W2166205453 @default.
- W2894977741 cites W2180980616 @default.
- W2894977741 cites W2255851399 @default.
- W2894977741 cites W2324883073 @default.
- W2894977741 cites W2343654708 @default.
- W2894977741 cites W2444206094 @default.
- W2894977741 cites W2507733625 @default.
- W2894977741 cites W2512136889 @default.
- W2894977741 cites W2531700824 @default.
- W2894977741 cites W2533592562 @default.
- W2894977741 cites W2571372048 @default.
- W2894977741 cites W2604719624 @default.
- W2894977741 cites W2768847639 @default.
- W2894977741 cites W2794482808 @default.
- W2894977741 cites W2799954306 @default.
- W2894977741 doi "https://doi.org/10.3390/proteomes6040039" @default.
- W2894977741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313901" @default.
- W2894977741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301203" @default.
- W2894977741 hasPublicationYear "2018" @default.
- W2894977741 type Work @default.
- W2894977741 sameAs 2894977741 @default.
- W2894977741 citedByCount "12" @default.
- W2894977741 countsByYear W28949777412019 @default.
- W2894977741 countsByYear W28949777412020 @default.
- W2894977741 countsByYear W28949777412021 @default.
- W2894977741 countsByYear W28949777412022 @default.
- W2894977741 crossrefType "journal-article" @default.
- W2894977741 hasAuthorship W2894977741A5013259171 @default.
- W2894977741 hasAuthorship W2894977741A5030975938 @default.
- W2894977741 hasAuthorship W2894977741A5053630827 @default.
- W2894977741 hasAuthorship W2894977741A5076635917 @default.
- W2894977741 hasAuthorship W2894977741A5084540545 @default.