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- W2894980875 abstract "Kleinia odora is a wild plant growing in Saudi Arabia and consumed by both animals and people. The plant is rich in triterpenes that are known for their anti-inflammatory activity. In this study, the major triterpenes from this plant were isolated, identified and assessed for their anti-inflammatory activity. Different chromatographic and spectroscopic techniques were used to isolate and identify the major triterpenes isolated from the aerial parts of K. odora. Anti-inflammatory activities of isolated compounds were assessed according to radicle scavenging activity and their impact on NFκB. The assessment of anti-inflammatory activity was performed by measuring supernatant concentrations of inflammatory cytokines released from human Peripheral Blood Mononuclear Cell (PBMCs) previously fuelled by phytohaemagglutinin (PHA). Chemical investigation of K. odora lead to isolation of lupeol acetate (1), lupenone (2), friedelin (3), lupeol (4), epilupeol (5) and oleanolic acid (6).Compounds 1 and 2 showed the best activity as a free radical scavenger in DPPH assay. Moreover, they showed the highest potency as anti-inflammatory through decreasing NFκB p65 content, TNF-α IL-6, and IL-1β levels in PHA-stimulated (PBMCs). Optimum anti-inflammatory effects have been shown at 100 μM but at lower concentrations only lupane nucleus with acetate or ketone at position 3 showed the optimum activity as in compounds 1 and 2, respectively. It could be concluded that maximum anti-inflammatory activity is obtained from lupine skeleton with acetate or ketone at position C-3." @default.
- W2894980875 created "2018-10-12" @default.
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- W2894980875 date "2018-10-01" @default.
- W2894980875 modified "2023-09-27" @default.
- W2894980875 title "Anti-inflammatory activity of Kleinia odora" @default.
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- W2894980875 doi "https://doi.org/10.1016/j.eujim.2018.10.005" @default.
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