FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894983693> ?p ?o ?g. }

• W2894983693 endingPage "74" @default.
• W2894983693 startingPage "67" @default.
• W2894983693 abstract "Studies have evaluated the association of miRNA-423 C>A genotyping with the susceptibility to various diseases such cancers, atherosclerosis and inflammatory bowel disease but the results were contradictory. However, no studies have reported the association between miRNA-423 rs6505162 C>A polymorphism and susceptibility of coronary artery disease. MicroRNAs regulate expression of multiple genes involved in atherogenesis. Therefore, we investigated the association of microRNA-423C>T gene variations with susceptibility to coronary artery disease.This study was conducted on 100 coronary artery disease patients and 117 matched healthy controls. The genotyping of the microRNA-423 rs6505162C>A was performed by using Amplification refractory mutation system PCR method (ARMS-PCR).A significant difference was observed in the genotype distribution among the coronary artery disease cases and sex-matched healthy controls (P=0.048). The frequencies of all three genotypes CC, CA, AA reported in the patient's samples were 55%, 41% and 4% and in the healthy controls samples were 55%, 41% and 4% respectively. Our findings showed that the microRNA-423 C>A variant was associated with an increased risk of coronary artery disease in codominant model (OR = 1.96, 95 % CI, 1.12-3.42; RR 1.35(1.05-1.75, p=0.017) of microRNA-423CA genotype and significant association in dominant model (OR 1.97, 95% CI (1.14-3.39), (CA+AA vs CC) and non-significant association for recessive model (OR=1.42, 95%CI=0.42-4.83, P=0.56, AA vs CC+CA).While, the A allele significantly increased the risk of coronary artery disease (OR =1.56, 95 % CI, 1.03-2.37; p=0.035) compared to C allele. Therefore, it was observed that more than 1.96, 1.97 and 1.56 fold increased risk of developing coronary artery disease.Our findings indicated that microRNA-423 CA genotype and A allele are associated with an increased susceptibility to Coronary artery disease." @default.
• W2894983693 created "2018-10-12" @default.
• W2894983693 creator A5025703530 @default.
• W2894983693 creator A5035103889 @default.
• W2894983693 creator A5042009810 @default.
• W2894983693 creator A5055610724 @default.
• W2894983693 creator A5064819189 @default.
• W2894983693 creator A5064852873 @default.
• W2894983693 creator A5073071262 @default.
• W2894983693 creator A5078514240 @default.
• W2894983693 date "2019-01-03" @default.
• W2894983693 modified "2023-10-14" @default.
• W2894983693 title "Potential Impact of MicroRNA-423 Gene Variability in Coronary Artery Disease" @default.
• W2894983693 cites W1606839159 @default.
• W2894983693 cites W1650965741 @default.
• W2894983693 cites W1964654376 @default.
• W2894983693 cites W1972692904 @default.
• W2894983693 cites W1976612131 @default.
• W2894983693 cites W1980462191 @default.
• W2894983693 cites W1989891963 @default.
• W2894983693 cites W1992152105 @default.
• W2894983693 cites W2008751692 @default.
• W2894983693 cites W2011192430 @default.
• W2894983693 cites W2026298859 @default.
• W2894983693 cites W2027655677 @default.
• W2894983693 cites W2052486422 @default.
• W2894983693 cites W2054574453 @default.
• W2894983693 cites W2054805566 @default.
• W2894983693 cites W2073882423 @default.
• W2894983693 cites W2089465141 @default.
• W2894983693 cites W2115910133 @default.
• W2894983693 cites W2126972822 @default.
• W2894983693 cites W2130008836 @default.
• W2894983693 cites W2148842621 @default.
• W2894983693 cites W2160427593 @default.
• W2894983693 cites W2254568118 @default.
• W2894983693 cites W2272054673 @default.
• W2894983693 cites W2280289381 @default.
• W2894983693 cites W2328852206 @default.
• W2894983693 cites W2466390755 @default.
• W2894983693 cites W2609659568 @default.
• W2894983693 cites W2740619578 @default.
• W2894983693 cites W2767565447 @default.
• W2894983693 cites W2775713637 @default.
• W2894983693 cites W2777091315 @default.
• W2894983693 cites W2789813840 @default.
• W2894983693 doi "https://doi.org/10.2174/1871530318666181005095724" @default.
• W2894983693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289085" @default.
• W2894983693 hasPublicationYear "2019" @default.
• W2894983693 type Work @default.
• W2894983693 sameAs 2894983693 @default.
• W2894983693 citedByCount "22" @default.
• W2894983693 countsByYear W28949836932019 @default.
• W2894983693 countsByYear W28949836932020 @default.
• W2894983693 countsByYear W28949836932021 @default.
• W2894983693 countsByYear W28949836932022 @default.
• W2894983693 countsByYear W28949836932023 @default.
• W2894983693 crossrefType "journal-article" @default.
• W2894983693 hasAuthorship W2894983693A5025703530 @default.
• W2894983693 hasAuthorship W2894983693A5035103889 @default.
• W2894983693 hasAuthorship W2894983693A5042009810 @default.
• W2894983693 hasAuthorship W2894983693A5055610724 @default.
• W2894983693 hasAuthorship W2894983693A5064819189 @default.
• W2894983693 hasAuthorship W2894983693A5064852873 @default.
• W2894983693 hasAuthorship W2894983693A5073071262 @default.
• W2894983693 hasAuthorship W2894983693A5078514240 @default.
• W2894983693 hasConcept C104317684 @default.
• W2894983693 hasConcept C126322002 @default.
• W2894983693 hasConcept C135763542 @default.
• W2894983693 hasConcept C145059251 @default.
• W2894983693 hasConcept C2778213512 @default.
• W2894983693 hasConcept C2779134260 @default.
• W2894983693 hasConcept C31467283 @default.
• W2894983693 hasConcept C54355233 @default.
• W2894983693 hasConcept C71924100 @default.
• W2894983693 hasConcept C86803240 @default.
• W2894983693 hasConcept C90924648 @default.
• W2894983693 hasConceptScore W2894983693C104317684 @default.
• W2894983693 hasConceptScore W2894983693C126322002 @default.
• W2894983693 hasConceptScore W2894983693C135763542 @default.
• W2894983693 hasConceptScore W2894983693C145059251 @default.
• W2894983693 hasConceptScore W2894983693C2778213512 @default.
• W2894983693 hasConceptScore W2894983693C2779134260 @default.
• W2894983693 hasConceptScore W2894983693C31467283 @default.
• W2894983693 hasConceptScore W2894983693C54355233 @default.
• W2894983693 hasConceptScore W2894983693C71924100 @default.
• W2894983693 hasConceptScore W2894983693C86803240 @default.
• W2894983693 hasConceptScore W2894983693C90924648 @default.
• W2894983693 hasIssue "1" @default.
• W2894983693 hasLocation W28949836931 @default.
• W2894983693 hasLocation W28949836932 @default.
• W2894983693 hasOpenAccess W2894983693 @default.
• W2894983693 hasPrimaryLocation W28949836931 @default.
• W2894983693 hasRelatedWork W1579334360 @default.
• W2894983693 hasRelatedWork W2004827278 @default.
• W2894983693 hasRelatedWork W2042629756 @default.
• W2894983693 hasRelatedWork W2349105149 @default.
• W2894983693 hasRelatedWork W2355663560 @default.

• next