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- W2894984069 abstract "Abstract Genetic analysis of late-onset Alzheimer’s disease risk has previously identified a network of largely microglial genes that form a transcriptional network. In transgenic mouse models of amyloid deposition we have previously shown that the expression of many of the mouse orthologs of these genes are co-ordinately up-regulated by amyloid deposition. Here we investigate whether systematic analysis of other members of this mouse amyloid-responsive network predicts other Alzheimer’s risk loci. This statistical comparison of the mouse amyloid-response network with Alzheimer’s disease genome-wide association studies identifies 5 other genetic risk loci for the disease ( OAS1, CXCL10, LAPTM5, ITGAM and LILRB4 ). This work suggests that genetic variability in the microglial response to amyloid deposition is a major determinant for Alzheimer’s risk. One Sentence Summary Identification of 5 new risk loci for Alzheimer’s by statistical comparison of mouse Aβ microglial response with gene-based SNPs from human GWAS" @default.
- W2894984069 created "2018-10-12" @default.
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- W2894984069 date "2018-10-08" @default.
- W2894984069 modified "2023-09-27" @default.
- W2894984069 title "Genetic variability in response to Aβ deposition influences Alzheimer’s risk" @default.
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- W2894984069 doi "https://doi.org/10.1101/437657" @default.
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