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- W2894989586 abstract "Significance Feeding behavior changes drastically with infection and is a conserved behavioral response. However, the mechanistic aspects of how this behavior provides a survival advantage are poorly understood. Metabolic reprogramming is emerging as a mechanism by which disease tolerance is established and coordinated to the type of inflammatory insult to support tissue function. The type of metabolism required for survival of parasitic infections has not yet been explored. Here, we report that inhibition of glycolysis utilizing 2-deoxy glucose (2DG) prevented the development of cerebral malaria. The 2DG did not affect pathogen burden, degree of anemia, or cerebral inflammation. Instead, 2DG improved disease tolerance by affecting hemostasis and greatly diminished the formation of intracerebral microthrombi and hemorrhage." @default.
- W2894989586 created "2018-10-12" @default.
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- W2894989586 date "2018-10-05" @default.
- W2894989586 modified "2023-09-30" @default.
- W2894989586 title "Glucose metabolism mediates disease tolerance in cerebral malaria" @default.
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- W2894989586 doi "https://doi.org/10.1073/pnas.1806376115" @default.
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