Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895003737> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2895003737 endingPage "85" @default.
- W2895003737 startingPage "78" @default.
- W2895003737 abstract "Pueraria total flavonids (PTF) can treat cardiovascular and cerebrovascular diseases, but it has poor membrane permeability and oral bioavailability. Some excipients, such as carbomer, chitosan, and hydroxypropyl methylcellulose, can improve the oral bioavailability. Traditional in vitro evaluation techniques, including the rat intestinal perfusion and cell line models, cannot evaluate PTF absorption and holistic transporters. This study evaluated excipients’ adhesiveness and effect on PTF transport across Caco-2 cell monolayer. cDNA microarrays identified gene expression changes in Caco-2 cells exposed to PTF and PTF with excipients, and revealed the mechanism underlying the effect of excipients on PTF absorption. In vitro adhesion and transport experiments across Caco-2 showed that excipients had higher adhesiveness to gastric mucosa and transport efficiency across Caco-2 cells than PTF alone. The interaction of PTF with excipients significantly changed the expression of some genes, which might influence the absorption rate of PTF. Different bioadhesive polymers can improve intestinal absorption of PTF, which was related to some genes affiliated to the ATP-binding cassette (ABC) and solute carrier transporter (SLC) to some extent." @default.
- W2895003737 created "2018-10-12" @default.
- W2895003737 creator A5045982053 @default.
- W2895003737 creator A5060002817 @default.
- W2895003737 creator A5064150875 @default.
- W2895003737 date "2019-01-01" @default.
- W2895003737 modified "2023-09-27" @default.
- W2895003737 title "Effect of bioadhesive excipients on absorption of total flavonids from Puerariae Lobatae Radix transporting across Caco-2 cell monolayer" @default.
- W2895003737 cites W1538499995 @default.
- W2895003737 cites W1921474434 @default.
- W2895003737 cites W1966781049 @default.
- W2895003737 cites W1975635279 @default.
- W2895003737 cites W1978597622 @default.
- W2895003737 cites W1980296334 @default.
- W2895003737 cites W1980321324 @default.
- W2895003737 cites W2000813105 @default.
- W2895003737 cites W2008576206 @default.
- W2895003737 cites W2014164434 @default.
- W2895003737 cites W2031502774 @default.
- W2895003737 cites W2056966258 @default.
- W2895003737 cites W2071101614 @default.
- W2895003737 cites W2080668531 @default.
- W2895003737 cites W2082647909 @default.
- W2895003737 cites W2083416982 @default.
- W2895003737 cites W2084554859 @default.
- W2895003737 cites W2087611912 @default.
- W2895003737 cites W2089809344 @default.
- W2895003737 cites W2108992042 @default.
- W2895003737 cites W2134673353 @default.
- W2895003737 cites W2135334365 @default.
- W2895003737 cites W2161791301 @default.
- W2895003737 cites W2374586205 @default.
- W2895003737 cites W2411394766 @default.
- W2895003737 doi "https://doi.org/10.1016/j.chmed.2018.10.001" @default.
- W2895003737 hasPublicationYear "2019" @default.
- W2895003737 type Work @default.
- W2895003737 sameAs 2895003737 @default.
- W2895003737 citedByCount "0" @default.
- W2895003737 crossrefType "journal-article" @default.
- W2895003737 hasAuthorship W2895003737A5045982053 @default.
- W2895003737 hasAuthorship W2895003737A5060002817 @default.
- W2895003737 hasAuthorship W2895003737A5064150875 @default.
- W2895003737 hasConcept C125287762 @default.
- W2895003737 hasConcept C159985019 @default.
- W2895003737 hasConcept C178790620 @default.
- W2895003737 hasConcept C181389837 @default.
- W2895003737 hasConcept C185592680 @default.
- W2895003737 hasConcept C192562407 @default.
- W2895003737 hasConcept C193176779 @default.
- W2895003737 hasConcept C202751555 @default.
- W2895003737 hasConcept C2776634624 @default.
- W2895003737 hasConcept C521977710 @default.
- W2895003737 hasConcept C55493867 @default.
- W2895003737 hasConcept C86803240 @default.
- W2895003737 hasConcept C98274493 @default.
- W2895003737 hasConceptScore W2895003737C125287762 @default.
- W2895003737 hasConceptScore W2895003737C159985019 @default.
- W2895003737 hasConceptScore W2895003737C178790620 @default.
- W2895003737 hasConceptScore W2895003737C181389837 @default.
- W2895003737 hasConceptScore W2895003737C185592680 @default.
- W2895003737 hasConceptScore W2895003737C192562407 @default.
- W2895003737 hasConceptScore W2895003737C193176779 @default.
- W2895003737 hasConceptScore W2895003737C202751555 @default.
- W2895003737 hasConceptScore W2895003737C2776634624 @default.
- W2895003737 hasConceptScore W2895003737C521977710 @default.
- W2895003737 hasConceptScore W2895003737C55493867 @default.
- W2895003737 hasConceptScore W2895003737C86803240 @default.
- W2895003737 hasConceptScore W2895003737C98274493 @default.
- W2895003737 hasIssue "1" @default.
- W2895003737 hasLocation W28950037371 @default.
- W2895003737 hasOpenAccess W2895003737 @default.
- W2895003737 hasPrimaryLocation W28950037371 @default.
- W2895003737 hasRelatedWork W116375467 @default.
- W2895003737 hasRelatedWork W118449968 @default.
- W2895003737 hasRelatedWork W1887906482 @default.
- W2895003737 hasRelatedWork W1908517791 @default.
- W2895003737 hasRelatedWork W2007260382 @default.
- W2895003737 hasRelatedWork W2131557988 @default.
- W2895003737 hasRelatedWork W2170740785 @default.
- W2895003737 hasRelatedWork W2760523027 @default.
- W2895003737 hasRelatedWork W2895003737 @default.
- W2895003737 hasRelatedWork W4324369038 @default.
- W2895003737 hasVolume "11" @default.
- W2895003737 isParatext "false" @default.
- W2895003737 isRetracted "false" @default.
- W2895003737 magId "2895003737" @default.
- W2895003737 workType "article" @default.