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- W2895021024 abstract "{[Ag(FBPY)2]+(FBPYH)+}(OTF)2, FBPY=FPhC(O)C(H)PPh3, FBPYH =FC6H4COCH2PPh3, OTF=CF3SO3, a ylidic complex, was prepared through the reaction of silver trifluoromethanesulfonate (AgOTf) and ylide [FBPY] in 1:2 M ratio and characterized using various techniques. X-ray crystallography was used to determine the crystal structure. CT-DNA binding interaction of the synthesis compound was tested by fluorescence spectroscopy, UV–Vis absorption spectroscopy, and viscometric titration method. The data by the analysis revealed that the Ag complex could bind to DNA through the groove binding mode. The emission titration of bovine serum albumin (BSA) with the complex showed a static process for the fluorescence quenching mechanism of BSA. In addition, the donor (BSA) - acceptor (Ag complex) distance was calculated by using fluorescence resonance energy transfer (FRET). The results of competitive binding by means of Warfarin, Ibuprofen and Digoxin site markers revealed that the complex was bound to the site I of BSA. Notably, molecular docking studies were used for the determination of DNA and BSA-Ag (I) complex binding. Finally, it was shown that the complex had remarkable in vitro cytotoxicity against melanoma (B16F0) and colon carcinoma (C26) cancer cell lines, as shown by the use of MTT([3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide] colorimetric assay." @default.
- W2895021024 created "2018-10-12" @default.
- W2895021024 creator A5006314010 @default.
- W2895021024 creator A5006330413 @default.
- W2895021024 creator A5008022983 @default.
- W2895021024 creator A5019266817 @default.
- W2895021024 creator A5019467887 @default.
- W2895021024 creator A5048528640 @default.
- W2895021024 date "2019-02-01" @default.
- W2895021024 modified "2023-10-10" @default.
- W2895021024 title "A novel silver (I) complex of α-keto phosphorus ylide: Synthesis, characterization, crystal structure, biomolecular interaction studies, molecular docking and in vitro cytotoxic evaluation" @default.
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- W2895021024 doi "https://doi.org/10.1016/j.molstruc.2018.09.063" @default.
- W2895021024 hasPublicationYear "2019" @default.
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