Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895029854> ?p ?o ?g. }
- W2895029854 abstract "Immediate-early genes (IEGs) are rapidly and transiently induced following excitatory neuronal activity including maximal electroconvulsive shock treatment (ECT). The rapid RNA response can be blocked by the sodium channel antagonist tetrodotoxin (TTX), without blocking seizures, indicating a role for electrical stimulation in electroconvulsive shock-induced mRNA responses. In behaving animals, Arc mRNA is selectively transcribed following patterned neuronal activity and rapidly trafficked to dendrites where it preferentially accumulates at active synapses for local translation. Here we examined whether there is a relationship between the current intensities that elicit seizures and the threshold for Arc mRNA transcription in the rat hippocampus and perirhinal cortex (PRC). Animals received ECT of varying current intensities (0, 20, 40 65, 77 and 85 mA) and were sacrificed 5 min later. While significantly more CA1, CA3 and perirhinal pyramidal cells expressed Arc at the lowest stimulus intensity compared to granule cells, there was an abrupt threshold transition that occurred in all four regions at 77 mA. This precise threshold for Arc expression in all temporal lobe neurons examined may involve regulation of the calcium-dependent mechanisms that are upstream to activity-dependent IEG transcription." @default.
- W2895029854 created "2018-10-12" @default.
- W2895029854 creator A5000531496 @default.
- W2895029854 creator A5035655874 @default.
- W2895029854 creator A5037628555 @default.
- W2895029854 creator A5042422785 @default.
- W2895029854 creator A5047951532 @default.
- W2895029854 creator A5062207923 @default.
- W2895029854 creator A5085728194 @default.
- W2895029854 creator A5091305201 @default.
- W2895029854 date "2018-11-01" @default.
- W2895029854 modified "2023-10-06" @default.
- W2895029854 title "Seizure-Induced Arc mRNA Expression Thresholds in Rat Hippocampus and Perirhinal Cortex" @default.
- W2895029854 cites W1580729786 @default.
- W2895029854 cites W1607671357 @default.
- W2895029854 cites W1934624205 @default.
- W2895029854 cites W1961476520 @default.
- W2895029854 cites W1968996804 @default.
- W2895029854 cites W1980004837 @default.
- W2895029854 cites W1983540839 @default.
- W2895029854 cites W1992965882 @default.
- W2895029854 cites W1996490889 @default.
- W2895029854 cites W1998394223 @default.
- W2895029854 cites W1999838582 @default.
- W2895029854 cites W2000342726 @default.
- W2895029854 cites W2003102216 @default.
- W2895029854 cites W2024344682 @default.
- W2895029854 cites W2033587421 @default.
- W2895029854 cites W2034998738 @default.
- W2895029854 cites W2042834556 @default.
- W2895029854 cites W2049769306 @default.
- W2895029854 cites W2051692581 @default.
- W2895029854 cites W2054146576 @default.
- W2895029854 cites W2057608535 @default.
- W2895029854 cites W205881385 @default.
- W2895029854 cites W2063659779 @default.
- W2895029854 cites W2073145989 @default.
- W2895029854 cites W2076312647 @default.
- W2895029854 cites W2081150698 @default.
- W2895029854 cites W2087298647 @default.
- W2895029854 cites W2096916130 @default.
- W2895029854 cites W2099814708 @default.
- W2895029854 cites W2100351972 @default.
- W2895029854 cites W2102137096 @default.
- W2895029854 cites W2102973376 @default.
- W2895029854 cites W2109309568 @default.
- W2895029854 cites W2113849086 @default.
- W2895029854 cites W2114559471 @default.
- W2895029854 cites W2121198501 @default.
- W2895029854 cites W2140474748 @default.
- W2895029854 cites W2141391979 @default.
- W2895029854 cites W2147101007 @default.
- W2895029854 cites W2159475829 @default.
- W2895029854 cites W2166138822 @default.
- W2895029854 cites W2281873405 @default.
- W2895029854 cites W2322872397 @default.
- W2895029854 cites W2558947971 @default.
- W2895029854 cites W2742564158 @default.
- W2895029854 cites W2752963108 @default.
- W2895029854 cites W2775830737 @default.
- W2895029854 cites W4230535003 @default.
- W2895029854 cites W954230352 @default.
- W2895029854 cites W2186135786 @default.
- W2895029854 doi "https://doi.org/10.3389/fnsys.2018.00053" @default.
- W2895029854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6221912" @default.
- W2895029854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30443206" @default.
- W2895029854 hasPublicationYear "2018" @default.
- W2895029854 type Work @default.
- W2895029854 sameAs 2895029854 @default.
- W2895029854 citedByCount "3" @default.
- W2895029854 countsByYear W28950298542020 @default.
- W2895029854 countsByYear W28950298542023 @default.
- W2895029854 crossrefType "journal-article" @default.
- W2895029854 hasAuthorship W2895029854A5000531496 @default.
- W2895029854 hasAuthorship W2895029854A5035655874 @default.
- W2895029854 hasAuthorship W2895029854A5037628555 @default.
- W2895029854 hasAuthorship W2895029854A5042422785 @default.
- W2895029854 hasAuthorship W2895029854A5047951532 @default.
- W2895029854 hasAuthorship W2895029854A5062207923 @default.
- W2895029854 hasAuthorship W2895029854A5085728194 @default.
- W2895029854 hasAuthorship W2895029854A5091305201 @default.
- W2895029854 hasBestOaLocation W28950298541 @default.
- W2895029854 hasConcept C104317684 @default.
- W2895029854 hasConcept C105580179 @default.
- W2895029854 hasConcept C126322002 @default.
- W2895029854 hasConcept C134018914 @default.
- W2895029854 hasConcept C150194340 @default.
- W2895029854 hasConcept C15744967 @default.
- W2895029854 hasConcept C169760540 @default.
- W2895029854 hasConcept C170493617 @default.
- W2895029854 hasConcept C185592680 @default.
- W2895029854 hasConcept C24998067 @default.
- W2895029854 hasConcept C2524010 @default.
- W2895029854 hasConcept C2776741303 @default.
- W2895029854 hasConcept C2778186239 @default.
- W2895029854 hasConcept C2778317145 @default.
- W2895029854 hasConcept C2779555244 @default.
- W2895029854 hasConcept C2779918689 @default.
- W2895029854 hasConcept C2781099131 @default.
- W2895029854 hasConcept C33923547 @default.