FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895035837> ?p ?o ?g. }

• W2895035837 endingPage "1952" @default.
• W2895035837 startingPage "1943" @default.
• W2895035837 abstract "Objectives: Low tidal volume (= tidal volume ≤ 6 mL/kg, predicted body weight) ventilation using volume control benefits patients with acute respiratory distress syndrome. Airway pressure release ventilation is an alternative to low tidal volume-volume control ventilation, but the release breaths generated are variable and can exceed tidal volume breaths of low tidal volume-volume control. We evaluate the application of a low tidal volume-compatible airway pressure release ventilation protocol that manages release volumes on both clinical and feasibility endpoints. Design: We designed a prospective randomized trial in patients with acute hypoxemic respiratory failure. We randomized patients to low tidal volume-volume control, low tidal volume-airway pressure release ventilation, and traditional airway pressure release ventilation with a planned enrollment of 246 patients. The study was stopped early because of low enrollment and inability to consistently achieve tidal volumes less than 6.5 mL/kg in the low tidal volume-airway pressure release ventilation arm. Although the primary clinical study endpoint was Pa o 2 /F io 2 on study day 3, we highlight the feasibility outcomes related to tidal volumes in both arms. Setting: Four Intermountain Healthcare tertiary ICUs. Patients: Adult ICU patients with hypoxemic respiratory failure anticipated to require prolonged mechanical ventilation. Interventions: Low tidal volume-volume control, airway pressure release ventilation, and low tidal volume-airway pressure release ventilation. Measurements and Main Results: We observed wide variability and higher tidal (release for airway pressure release ventilation) volumes in both airway pressure release ventilation (8.6 mL/kg; 95% CI, 7.8–9.6) and low tidal volume-airway pressure release ventilation (8.0; 95% CI, 7.3–8.9) than volume control (6.8; 95% CI, 6.2–7.5; p = 0.005) with no difference between airway pressure release ventilation and low tidal volume-airway pressure release ventilation ( p = 0.58). Recognizing the limitations of small sample size, we observed no difference in 52 patients in day 3 Pa o 2 / F io 2 ( p = 0.92). We also observed no significant difference between arms in sedation, vasoactive medications, or occurrence of pneumothorax. Conclusions: Airway pressure release ventilation resulted in release volumes often exceeding 12 mL/kg despite a protocol designed to target low tidal volume ventilation. Current airway pressure release ventilation protocols are unable to achieve consistent and reproducible delivery of low tidal volume ventilation goals. A large-scale efficacy trial of low tidal volume-airway pressure release ventilation is not feasible at this time in the absence of an explicit, generalizable, and reproducible low tidal volume-airway pressure release ventilation protocol." @default.
• W2895035837 created "2018-10-12" @default.
• W2895035837 creator A5013500553 @default.
• W2895035837 creator A5013862976 @default.
• W2895035837 creator A5017704874 @default.
• W2895035837 creator A5024730172 @default.
• W2895035837 creator A5043245910 @default.
• W2895035837 creator A5050001215 @default.
• W2895035837 creator A5061729657 @default.
• W2895035837 creator A5065388800 @default.
• W2895035837 creator A5068031111 @default.
• W2895035837 date "2018-12-01" @default.
• W2895035837 modified "2023-10-16" @default.
• W2895035837 title "Randomized Feasibility Trial of a Low Tidal Volume-Airway Pressure Release Ventilation Protocol Compared With Traditional Airway Pressure Release Ventilation and Volume Control Ventilation Protocols" @default.
• W2895035837 cites W1444345791 @default.
• W2895035837 cites W1476289819 @default.
• W2895035837 cites W1583083564 @default.
• W2895035837 cites W1588145017 @default.
• W2895035837 cites W1819318535 @default.
• W2895035837 cites W1972198342 @default.
• W2895035837 cites W1995637420 @default.
• W2895035837 cites W2001935320 @default.
• W2895035837 cites W2004114186 @default.
• W2895035837 cites W2007162946 @default.
• W2895035837 cites W2009478257 @default.
• W2895035837 cites W2012186158 @default.
• W2895035837 cites W2013163251 @default.
• W2895035837 cites W2016948481 @default.
• W2895035837 cites W2021530797 @default.
• W2895035837 cites W2026790009 @default.
• W2895035837 cites W2031723182 @default.
• W2895035837 cites W2035101528 @default.
• W2895035837 cites W2039559413 @default.
• W2895035837 cites W2045464069 @default.
• W2895035837 cites W2051488943 @default.
• W2895035837 cites W2059634691 @default.
• W2895035837 cites W2061513563 @default.
• W2895035837 cites W2071938049 @default.
• W2895035837 cites W2083774342 @default.
• W2895035837 cites W2092380505 @default.
• W2895035837 cites W2105999224 @default.
• W2895035837 cites W2119437552 @default.
• W2895035837 cites W2120144999 @default.
• W2895035837 cites W2120164024 @default.
• W2895035837 cites W2134592673 @default.
• W2895035837 cites W2141392701 @default.
• W2895035837 cites W2143626238 @default.
• W2895035837 cites W2143748013 @default.
• W2895035837 cites W2144195476 @default.
• W2895035837 cites W2152196533 @default.
• W2895035837 cites W2157493683 @default.
• W2895035837 cites W2158431737 @default.
• W2895035837 cites W2162001089 @default.
• W2895035837 cites W2162002744 @default.
• W2895035837 cites W2164283257 @default.
• W2895035837 cites W2166449735 @default.
• W2895035837 cites W2170809086 @default.
• W2895035837 cites W2176560993 @default.
• W2895035837 cites W2197443566 @default.
• W2895035837 cites W2333411966 @default.
• W2895035837 cites W2345622111 @default.
• W2895035837 cites W2396739879 @default.
• W2895035837 cites W2399493496 @default.
• W2895035837 cites W2413547302 @default.
• W2895035837 cites W2430829396 @default.
• W2895035837 cites W2463144296 @default.
• W2895035837 cites W2511263716 @default.
• W2895035837 cites W2523037481 @default.
• W2895035837 cites W2584285806 @default.
• W2895035837 cites W2596807004 @default.
• W2895035837 cites W2597070792 @default.
• W2895035837 cites W2739518862 @default.
• W2895035837 cites W2752084332 @default.
• W2895035837 cites W2754462717 @default.
• W2895035837 cites W2755613255 @default.
• W2895035837 cites W2796588153 @default.
• W2895035837 cites W36430204 @default.
• W2895035837 cites W46971959 @default.
• W2895035837 cites W29272602 @default.
• W2895035837 doi "https://doi.org/10.1097/ccm.0000000000003437" @default.
• W2895035837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6250244" @default.
• W2895035837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30277890" @default.
• W2895035837 hasPublicationYear "2018" @default.
• W2895035837 type Work @default.
• W2895035837 sameAs 2895035837 @default.
• W2895035837 citedByCount "25" @default.
• W2895035837 countsByYear W28950358372019 @default.
• W2895035837 countsByYear W28950358372020 @default.
• W2895035837 countsByYear W28950358372021 @default.
• W2895035837 countsByYear W28950358372022 @default.
• W2895035837 countsByYear W28950358372023 @default.
• W2895035837 crossrefType "journal-article" @default.
• W2895035837 hasAuthorship W2895035837A5013500553 @default.
• W2895035837 hasAuthorship W2895035837A5013862976 @default.
• W2895035837 hasAuthorship W2895035837A5017704874 @default.
• W2895035837 hasAuthorship W2895035837A5024730172 @default.
• W2895035837 hasAuthorship W2895035837A5043245910 @default.
• W2895035837 hasAuthorship W2895035837A5050001215 @default.

• next