Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895043619> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2895043619 abstract "Objective. In nondiabetic healthy individuals, insulin secretion and sensitivity are linked by a negative feedback loop characterized by a hyperbolic function. We aimed to study the association of traditional insulin resistance (IR) factors with insulin secretion and sensitivity, and to determine whether the hyperbolic equilibrium of this relation is preserved in patients with rheumatoid arthritis (RA). Methods. This was a cross-sectional study encompassing 361 nondiabetic individuals: 151 with RA and 210 controls. Insulin, C-peptide, and IR indices by homeostatic model (HOMA2) were assessed. A multivariable analysis was performed to evaluate the differences in the correlation of traditional IR-related factors with glucose homeostasis molecules, as well as IR indices between patients and controls. Nonlinear regression analysis was used to assess the hyperbolic relation of insulin sensitivity and secretion. Results. HOMA2-IR indices were higher in patients with RA than controls. Hepatic insulin extraction, as assessed by the insulin:C-peptide molar ratio, was lower in patients with RA after multivariable analysis (0.08 ± 0.02 vs 0.14 ± 0.07, p < 0.001). Traditional IR-related factors showed significantly lower adjusted correlation coefficients with IR indices in patients with RA. The association between insulin sensitivity and secretion showed a different hyperbolic relation in patients with RA: the variability explained by the curve was lower in RA (nonlinear r 2 = 0.845 vs r 2 = 0.928, p = 0.001) and β coefficients (−0.74, 95% CI −0.77 to −0.70 vs −1.09, 95% CI −1.17 to −1.02, ng/ml, p < 0.001) were different in RA. Conclusion. The traditional factors associated with IR in healthy individuals are less related to IR in patients with RA. Insulin sensitivity and secretion yield a different hyperbolic equilibrium in RA." @default.
- W2895043619 created "2018-10-12" @default.
- W2895043619 creator A5002655652 @default.
- W2895043619 creator A5009134320 @default.
- W2895043619 creator A5009534704 @default.
- W2895043619 creator A5016922988 @default.
- W2895043619 creator A5032288913 @default.
- W2895043619 creator A5041530480 @default.
- W2895043619 creator A5049778476 @default.
- W2895043619 creator A5072733051 @default.
- W2895043619 creator A5087054326 @default.
- W2895043619 date "2018-10-01" @default.
- W2895043619 modified "2023-10-17" @default.
- W2895043619 title "Relationship Between Insulin Sensitivity and β-Cell Secretion in Nondiabetic Subjects with Rheumatoid Arthritis" @default.
- W2895043619 cites W2019055265 @default.
- W2895043619 cites W2021522110 @default.
- W2895043619 cites W2025578932 @default.
- W2895043619 cites W2030153054 @default.
- W2895043619 cites W2041388322 @default.
- W2895043619 cites W2042267006 @default.
- W2895043619 cites W2056526065 @default.
- W2895043619 cites W2060116897 @default.
- W2895043619 cites W2061309116 @default.
- W2895043619 cites W2064938665 @default.
- W2895043619 cites W2066898102 @default.
- W2895043619 cites W2076953885 @default.
- W2895043619 cites W2090282100 @default.
- W2895043619 cites W2104669609 @default.
- W2895043619 cites W2110177517 @default.
- W2895043619 cites W2119227351 @default.
- W2895043619 cites W2122839820 @default.
- W2895043619 cites W2124620553 @default.
- W2895043619 cites W2125871179 @default.
- W2895043619 cites W2136125467 @default.
- W2895043619 cites W2138598178 @default.
- W2895043619 cites W2143835145 @default.
- W2895043619 cites W2150559592 @default.
- W2895043619 cites W2150709240 @default.
- W2895043619 cites W2162344377 @default.
- W2895043619 cites W2334962183 @default.
- W2895043619 cites W2551445610 @default.
- W2895043619 cites W4241883936 @default.
- W2895043619 doi "https://doi.org/10.3899/jrheum.180198" @default.
- W2895043619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275261" @default.
- W2895043619 hasPublicationYear "2018" @default.
- W2895043619 type Work @default.
- W2895043619 sameAs 2895043619 @default.
- W2895043619 citedByCount "9" @default.
- W2895043619 countsByYear W28950436192019 @default.
- W2895043619 countsByYear W28950436192020 @default.
- W2895043619 countsByYear W28950436192021 @default.
- W2895043619 countsByYear W28950436192022 @default.
- W2895043619 crossrefType "journal-article" @default.
- W2895043619 hasAuthorship W2895043619A5002655652 @default.
- W2895043619 hasAuthorship W2895043619A5009134320 @default.
- W2895043619 hasAuthorship W2895043619A5009534704 @default.
- W2895043619 hasAuthorship W2895043619A5016922988 @default.
- W2895043619 hasAuthorship W2895043619A5032288913 @default.
- W2895043619 hasAuthorship W2895043619A5041530480 @default.
- W2895043619 hasAuthorship W2895043619A5049778476 @default.
- W2895043619 hasAuthorship W2895043619A5072733051 @default.
- W2895043619 hasAuthorship W2895043619A5087054326 @default.
- W2895043619 hasConcept C126322002 @default.
- W2895043619 hasConcept C134018914 @default.
- W2895043619 hasConcept C2777391703 @default.
- W2895043619 hasConcept C2777575956 @default.
- W2895043619 hasConcept C2779306644 @default.
- W2895043619 hasConcept C63645605 @default.
- W2895043619 hasConcept C71924100 @default.
- W2895043619 hasConceptScore W2895043619C126322002 @default.
- W2895043619 hasConceptScore W2895043619C134018914 @default.
- W2895043619 hasConceptScore W2895043619C2777391703 @default.
- W2895043619 hasConceptScore W2895043619C2777575956 @default.
- W2895043619 hasConceptScore W2895043619C2779306644 @default.
- W2895043619 hasConceptScore W2895043619C63645605 @default.
- W2895043619 hasConceptScore W2895043619C71924100 @default.
- W2895043619 hasLocation W28950436191 @default.
- W2895043619 hasLocation W28950436192 @default.
- W2895043619 hasOpenAccess W2895043619 @default.
- W2895043619 hasPrimaryLocation W28950436191 @default.
- W2895043619 hasRelatedWork W138803513 @default.
- W2895043619 hasRelatedWork W1986132654 @default.
- W2895043619 hasRelatedWork W2010140898 @default.
- W2895043619 hasRelatedWork W2010484394 @default.
- W2895043619 hasRelatedWork W2018456957 @default.
- W2895043619 hasRelatedWork W2056849036 @default.
- W2895043619 hasRelatedWork W2082140668 @default.
- W2895043619 hasRelatedWork W2138081409 @default.
- W2895043619 hasRelatedWork W2151350502 @default.
- W2895043619 hasRelatedWork W2378290744 @default.
- W2895043619 isParatext "false" @default.
- W2895043619 isRetracted "false" @default.
- W2895043619 magId "2895043619" @default.
- W2895043619 workType "article" @default.