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• W2895048801 abstract "Abstract A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional analysis of transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate and periportal) of human liver. We identify pronounced anti-correlated transcriptional and methylation gradients including a core of 271 genes controlling zonated metabolic and morphogen networks and observe a prominent porto-central gradient of DNA methylation at binding sites of 46 transcription factors. The gradient includes an epigenetic and transcriptional Wnt signature supporting the concept of a pericentral hepatocyte regeneration pathway under steady-state conditions. While donors with non-alcoholic fatty liver disease show consistent gene expression differences corresponding to the severity of the disease across all zones, the relative zonated gene expression and DNA methylation patterns remain unchanged. Overall our data provide a wealth of new positional insights into zonal networks controlled by epigenetic and transcriptional gradients in human liver." @default.
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• W2895048801 date "2018-10-08" @default.
• W2895048801 modified "2023-10-15" @default.
• W2895048801 title "Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control" @default.
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• W2895048801 doi "https://doi.org/10.1038/s41467-018-06611-5" @default.
• W2895048801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6175862" @default.
• W2895048801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297808" @default.
• W2895048801 hasPublicationYear "2018" @default.
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