Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895049724> ?p ?o ?g. }
- W2895049724 abstract "Mortality rates in influenza appear to have been shaped by evolution. During the 1918 pandemic, mortality rates were lower in children compared with adults. This mortality difference occurs in a wide variety of infectious diseases. It has been replicated in mice and might be due to greater tolerance of infection, not greater resistance. Importantly, combination treatment with inexpensive and widely available generic drugs (e.g. statins and angiotensin receptor blockers) might change the damaging host response in adults to a more tolerant response in children. These drugs might work by modifying endothelial dysfunction, mitochondrial biogenesis and immunometabolism. Treating the host response might be the only practical way to reduce global mortality during the next influenza pandemic. It might also help reduce mortality due to seasonal influenza and other forms of acute critical illness. To realize these benefits, we need laboratory and clinical studies of host response treatment before and after puberty." @default.
- W2895049724 created "2018-10-12" @default.
- W2895049724 creator A5025786945 @default.
- W2895049724 date "2018-10-03" @default.
- W2895049724 modified "2023-09-30" @default.
- W2895049724 title "Influenza, evolution, and the next pandemic" @default.
- W2895049724 cites W1503241441 @default.
- W2895049724 cites W1522146641 @default.
- W2895049724 cites W185214937 @default.
- W2895049724 cites W1872986167 @default.
- W2895049724 cites W1939922392 @default.
- W2895049724 cites W1963547303 @default.
- W2895049724 cites W1965003777 @default.
- W2895049724 cites W1969987659 @default.
- W2895049724 cites W1987496713 @default.
- W2895049724 cites W1990204346 @default.
- W2895049724 cites W1992974015 @default.
- W2895049724 cites W2005847060 @default.
- W2895049724 cites W2012929392 @default.
- W2895049724 cites W2014527201 @default.
- W2895049724 cites W2023424190 @default.
- W2895049724 cites W2023511584 @default.
- W2895049724 cites W2043931994 @default.
- W2895049724 cites W2045688706 @default.
- W2895049724 cites W2047214198 @default.
- W2895049724 cites W2047563535 @default.
- W2895049724 cites W2051818206 @default.
- W2895049724 cites W2053924017 @default.
- W2895049724 cites W2054393027 @default.
- W2895049724 cites W2055770088 @default.
- W2895049724 cites W2068005913 @default.
- W2895049724 cites W2075632360 @default.
- W2895049724 cites W2101076218 @default.
- W2895049724 cites W2104397221 @default.
- W2895049724 cites W2105898497 @default.
- W2895049724 cites W2106669223 @default.
- W2895049724 cites W2107097240 @default.
- W2895049724 cites W2122096836 @default.
- W2895049724 cites W2125379681 @default.
- W2895049724 cites W2132355007 @default.
- W2895049724 cites W2134235502 @default.
- W2895049724 cites W2153645417 @default.
- W2895049724 cites W2154349465 @default.
- W2895049724 cites W2156613610 @default.
- W2895049724 cites W2162112824 @default.
- W2895049724 cites W2167944937 @default.
- W2895049724 cites W2169362967 @default.
- W2895049724 cites W2207496959 @default.
- W2895049724 cites W2259226794 @default.
- W2895049724 cites W2279383360 @default.
- W2895049724 cites W2466572745 @default.
- W2895049724 cites W2468925656 @default.
- W2895049724 cites W2491683774 @default.
- W2895049724 cites W2502066314 @default.
- W2895049724 cites W2511842053 @default.
- W2895049724 cites W2519415500 @default.
- W2895049724 cites W2549953130 @default.
- W2895049724 cites W2551841976 @default.
- W2895049724 cites W2557207823 @default.
- W2895049724 cites W2559761837 @default.
- W2895049724 cites W2563076883 @default.
- W2895049724 cites W2570787279 @default.
- W2895049724 cites W2579756956 @default.
- W2895049724 cites W2586397021 @default.
- W2895049724 cites W2586919488 @default.
- W2895049724 cites W2591207079 @default.
- W2895049724 cites W2593784471 @default.
- W2895049724 cites W2604646618 @default.
- W2895049724 cites W2621065682 @default.
- W2895049724 cites W2621095500 @default.
- W2895049724 cites W2625703797 @default.
- W2895049724 cites W2735685363 @default.
- W2895049724 cites W2749083467 @default.
- W2895049724 cites W2753043298 @default.
- W2895049724 cites W2753148939 @default.
- W2895049724 cites W2756024829 @default.
- W2895049724 cites W2765838807 @default.
- W2895049724 cites W2766125601 @default.
- W2895049724 cites W2766504208 @default.
- W2895049724 cites W2766872285 @default.
- W2895049724 cites W2768202761 @default.
- W2895049724 cites W2775569101 @default.
- W2895049724 cites W2776550785 @default.
- W2895049724 cites W2782068205 @default.
- W2895049724 cites W2783963160 @default.
- W2895049724 cites W2784248396 @default.
- W2895049724 cites W2785246723 @default.
- W2895049724 cites W2788787138 @default.
- W2895049724 cites W2796298565 @default.
- W2895049724 cites W2802700163 @default.
- W2895049724 cites W2806008746 @default.
- W2895049724 cites W2808316969 @default.
- W2895049724 cites W3149695318 @default.
- W2895049724 doi "https://doi.org/10.1093/emph/eoy027" @default.
- W2895049724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6234328" @default.
- W2895049724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30455951" @default.
- W2895049724 hasPublicationYear "2018" @default.
- W2895049724 type Work @default.
- W2895049724 sameAs 2895049724 @default.
- W2895049724 citedByCount "11" @default.