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• W2895052996 abstract "Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance." @default.
• W2895052996 created "2018-10-12" @default.
• W2895052996 creator A5031009872 @default.
• W2895052996 creator A5057524215 @default.
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• W2895052996 date "2018-11-28" @default.
• W2895052996 modified "2023-10-13" @default.
• W2895052996 title "mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion" @default.
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• W2895052996 doi "https://doi.org/10.1097/qad.0000000000001997" @default.
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