FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895053364> ?p ?o ?g. }

• W2895053364 abstract "The aim of this study was to investigate the role of LAG1 longevity-assurance homologue 2 (LASS2) in papillary thyroid cancer (PTC).Immunohistochemistry staining was conducted to explore the expression levels of LASS2 in PTC tissues and adjacent normal thyroid tissues and nodular goiter tissues. Western blotting and RT-qPCR were performed to explore the expression levels of LASS2 in three PTC cell lines (TPC-1, K1, BCPAP). An Adv-LASS2-GFP recombinant adenovirus vector was constructed and transduced into BCPAP cells. Then CCK-8 assay, colony formation assay, cell cycle distribution, and apoptosis were performed. Western blotting was used to examine the expression of p21, cyclin D1, cyclin-dependent kinase 4, p53 and p-p53.LASS2 was downregulated in PTC tissues compared with adjacent thyroid tissues or nodular goiter tissues. In addition, the expression of LASS2 was found to be associated with TNM stage and lymph node metastasis. BCPAP cells expressed the lowest LASS2 compared to TPC-1 cells or K1 cells. Overexpression of LASS2 significantly inhibited proliferation, promoted apoptosis and caused G0/G1 cell cycle arrest in BCPAP cells. Furthermore, overexpression of LASS2 significantly increased the expression of p21, inhibited the expression of cyclin D1 and cyclin-dependent kinase 4, and increased the expression of p-p53, but did not effect the expression of p53 in BCPAP cells.Our findings indicate that overexpression of LASS2 inhibits PTC cell proliferation, promotes apoptosis and causes G0/G1 cell cycle arrest via a p53-dependent pathway. Thus, LASS2 may serve as a novel biomarker in PTC." @default.
• W2895053364 created "2018-10-12" @default.
• W2895053364 creator A5005043215 @default.
• W2895053364 creator A5010775196 @default.
• W2895053364 creator A5015748422 @default.
• W2895053364 creator A5017451693 @default.
• W2895053364 creator A5034574451 @default.
• W2895053364 creator A5038456446 @default.
• W2895053364 creator A5071994713 @default.
• W2895053364 creator A5083665597 @default.
• W2895053364 date "2018-10-01" @default.
• W2895053364 modified "2023-10-17" @default.
• W2895053364 title "Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer" @default.
• W2895053364 cites W1512072225 @default.
• W2895053364 cites W1550067152 @default.
• W2895053364 cites W1603631954 @default.
• W2895053364 cites W1980396417 @default.
• W2895053364 cites W1982140990 @default.
• W2895053364 cites W1985309874 @default.
• W2895053364 cites W1989875808 @default.
• W2895053364 cites W2005414926 @default.
• W2895053364 cites W2008930762 @default.
• W2895053364 cites W2014016589 @default.
• W2895053364 cites W2020811083 @default.
• W2895053364 cites W2021032365 @default.
• W2895053364 cites W2033882181 @default.
• W2895053364 cites W2035273416 @default.
• W2895053364 cites W2037337264 @default.
• W2895053364 cites W2038863966 @default.
• W2895053364 cites W2052562816 @default.
• W2895053364 cites W2054913654 @default.
• W2895053364 cites W2060222731 @default.
• W2895053364 cites W2069792474 @default.
• W2895053364 cites W2113397956 @default.
• W2895053364 cites W2117692326 @default.
• W2895053364 cites W2140291435 @default.
• W2895053364 cites W2147397865 @default.
• W2895053364 cites W2149643028 @default.
• W2895053364 cites W2170552969 @default.
• W2895053364 cites W2565257923 @default.
• W2895053364 cites W2588184387 @default.
• W2895053364 cites W2740308171 @default.
• W2895053364 cites W2758782427 @default.
• W2895053364 cites W2759005321 @default.
• W2895053364 cites W2779375131 @default.
• W2895053364 cites W2780058446 @default.
• W2895053364 cites W2783271777 @default.
• W2895053364 cites W2789306186 @default.
• W2895053364 cites W2795509664 @default.
• W2895053364 cites W2795798410 @default.
• W2895053364 cites W2796114424 @default.
• W2895053364 cites W2808485929 @default.
• W2895053364 cites W2883821996 @default.
• W2895053364 cites W2884009603 @default.
• W2895053364 cites W4236146633 @default.
• W2895053364 doi "https://doi.org/10.1186/s12935-018-0649-1" @default.
• W2895053364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167791" @default.
• W2895053364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30302058" @default.
• W2895053364 hasPublicationYear "2018" @default.
• W2895053364 type Work @default.
• W2895053364 sameAs 2895053364 @default.
• W2895053364 citedByCount "9" @default.
• W2895053364 countsByYear W28950533642019 @default.
• W2895053364 countsByYear W28950533642022 @default.
• W2895053364 countsByYear W28950533642023 @default.
• W2895053364 crossrefType "journal-article" @default.
• W2895053364 hasAuthorship W2895053364A5005043215 @default.
• W2895053364 hasAuthorship W2895053364A5010775196 @default.
• W2895053364 hasAuthorship W2895053364A5015748422 @default.
• W2895053364 hasAuthorship W2895053364A5017451693 @default.
• W2895053364 hasAuthorship W2895053364A5034574451 @default.
• W2895053364 hasAuthorship W2895053364A5038456446 @default.
• W2895053364 hasAuthorship W2895053364A5071994713 @default.
• W2895053364 hasAuthorship W2895053364A5083665597 @default.
• W2895053364 hasBestOaLocation W28950533641 @default.
• W2895053364 hasConcept C105696609 @default.
• W2895053364 hasConcept C120504264 @default.
• W2895053364 hasConcept C134018914 @default.
• W2895053364 hasConcept C190283241 @default.
• W2895053364 hasConcept C199835354 @default.
• W2895053364 hasConcept C2778437423 @default.
• W2895053364 hasConcept C2779761222 @default.
• W2895053364 hasConcept C2781461381 @default.
• W2895053364 hasConcept C29537977 @default.
• W2895053364 hasConcept C502942594 @default.
• W2895053364 hasConcept C526584372 @default.
• W2895053364 hasConcept C54355233 @default.
• W2895053364 hasConcept C55493867 @default.
• W2895053364 hasConcept C62112901 @default.
• W2895053364 hasConcept C86803240 @default.
• W2895053364 hasConceptScore W2895053364C105696609 @default.
• W2895053364 hasConceptScore W2895053364C120504264 @default.
• W2895053364 hasConceptScore W2895053364C134018914 @default.
• W2895053364 hasConceptScore W2895053364C190283241 @default.
• W2895053364 hasConceptScore W2895053364C199835354 @default.
• W2895053364 hasConceptScore W2895053364C2778437423 @default.
• W2895053364 hasConceptScore W2895053364C2779761222 @default.
• W2895053364 hasConceptScore W2895053364C2781461381 @default.
• W2895053364 hasConceptScore W2895053364C29537977 @default.
• W2895053364 hasConceptScore W2895053364C502942594 @default.

• next