FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895055937> ?p ?o ?g. }

• W2895055937 endingPage "7" @default.
• W2895055937 startingPage "1" @default.
• W2895055937 abstract "Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients.All UC patients receiving thiopurine monotherapy at three tertiary IBD centers from 1995 to 2015 were identified. The primary endpoint was steroid-free clinical remission. Secondary endpoints were mucosal healing (MH), defined as Mayo endoscopic subscore 0, long-term safety, and predictors of sustained clinical remission.We identified 192 patients, contributing a total of 747 person-years of follow-up (median follow-up 36 months, range 1-210 months). Steroid dependency was the most common indication for thiopurine treatment (58%). Steroid-free remission occurred in 45.3% of patients; 36.3% stopped thiopurines because of treatment failure and 18.2% for adverse events or intolerance. The cumulative probability of maintaining steroid-free remission while on thiopurine treatment was 87%, 76%, 67.6%, and 53.4% at 12, 24, 36, and 60 months, respectively. MH occurred in 57.9% of patients after a median of 18 months (range 5-96). No independent predictors of sustained clinical remission could be identified.Thiopurines represent an effective and safe long-term maintenance therapy for UC patients." @default.
• W2895055937 created "2018-10-12" @default.
• W2895055937 creator A5000171770 @default.
• W2895055937 creator A5018969457 @default.
• W2895055937 creator A5020092058 @default.
• W2895055937 creator A5030492974 @default.
• W2895055937 creator A5032304413 @default.
• W2895055937 creator A5058934291 @default.
• W2895055937 creator A5060132638 @default.
• W2895055937 creator A5064268494 @default.
• W2895055937 creator A5080153483 @default.
• W2895055937 date "2018-10-03" @default.
• W2895055937 modified "2023-09-24" @default.
• W2895055937 title "Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study" @default.
• W2895055937 cites W102427270 @default.
• W2895055937 cites W1450760876 @default.
• W2895055937 cites W1612648896 @default.
• W2895055937 cites W2002298808 @default.
• W2895055937 cites W2003681655 @default.
• W2895055937 cites W2009285886 @default.
• W2895055937 cites W2011008204 @default.
• W2895055937 cites W2012375240 @default.
• W2895055937 cites W2012974719 @default.
• W2895055937 cites W2031193040 @default.
• W2895055937 cites W2041686072 @default.
• W2895055937 cites W2056629400 @default.
• W2895055937 cites W2063697502 @default.
• W2895055937 cites W2072179061 @default.
• W2895055937 cites W2092474434 @default.
• W2895055937 cites W2098452439 @default.
• W2895055937 cites W2102242005 @default.
• W2895055937 cites W2108236283 @default.
• W2895055937 cites W2115000032 @default.
• W2895055937 cites W2120522488 @default.
• W2895055937 cites W2128036231 @default.
• W2895055937 cites W2128173849 @default.
• W2895055937 cites W2133264429 @default.
• W2895055937 cites W2149170290 @default.
• W2895055937 cites W2153190211 @default.
• W2895055937 cites W2167152940 @default.
• W2895055937 cites W2188248802 @default.
• W2895055937 cites W2272289608 @default.
• W2895055937 cites W2321205867 @default.
• W2895055937 cites W2322616832 @default.
• W2895055937 cites W2549518984 @default.
• W2895055937 cites W2580577961 @default.
• W2895055937 cites W2617944225 @default.
• W2895055937 cites W2910062148 @default.
• W2895055937 cites W4210662453 @default.
• W2895055937 cites W4211184682 @default.
• W2895055937 cites W4255059627 @default.
• W2895055937 cites W83815171 @default.
• W2895055937 doi "https://doi.org/10.1155/2018/4195968" @default.
• W2895055937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192086" @default.
• W2895055937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30402090" @default.
• W2895055937 hasPublicationYear "2018" @default.
• W2895055937 type Work @default.
• W2895055937 sameAs 2895055937 @default.
• W2895055937 citedByCount "7" @default.
• W2895055937 countsByYear W28950559372019 @default.
• W2895055937 countsByYear W28950559372020 @default.
• W2895055937 countsByYear W28950559372021 @default.
• W2895055937 countsByYear W28950559372022 @default.
• W2895055937 crossrefType "journal-article" @default.
• W2895055937 hasAuthorship W2895055937A5000171770 @default.
• W2895055937 hasAuthorship W2895055937A5018969457 @default.
• W2895055937 hasAuthorship W2895055937A5020092058 @default.
• W2895055937 hasAuthorship W2895055937A5030492974 @default.
• W2895055937 hasAuthorship W2895055937A5032304413 @default.
• W2895055937 hasAuthorship W2895055937A5058934291 @default.
• W2895055937 hasAuthorship W2895055937A5060132638 @default.
• W2895055937 hasAuthorship W2895055937A5064268494 @default.
• W2895055937 hasAuthorship W2895055937A5080153483 @default.
• W2895055937 hasBestOaLocation W28950559371 @default.
• W2895055937 hasConcept C126322002 @default.
• W2895055937 hasConcept C141071460 @default.
• W2895055937 hasConcept C168563851 @default.
• W2895055937 hasConcept C197934379 @default.
• W2895055937 hasConcept C203092338 @default.
• W2895055937 hasConcept C2776694085 @default.
• W2895055937 hasConcept C2778260677 @default.
• W2895055937 hasConcept C2778283404 @default.
• W2895055937 hasConcept C2779134260 @default.
• W2895055937 hasConcept C2780479503 @default.
• W2895055937 hasConcept C70917649 @default.
• W2895055937 hasConcept C71924100 @default.
• W2895055937 hasConcept C72563966 @default.
• W2895055937 hasConcept C90924648 @default.
• W2895055937 hasConceptScore W2895055937C126322002 @default.
• W2895055937 hasConceptScore W2895055937C141071460 @default.
• W2895055937 hasConceptScore W2895055937C168563851 @default.
• W2895055937 hasConceptScore W2895055937C197934379 @default.
• W2895055937 hasConceptScore W2895055937C203092338 @default.
• W2895055937 hasConceptScore W2895055937C2776694085 @default.
• W2895055937 hasConceptScore W2895055937C2778260677 @default.
• W2895055937 hasConceptScore W2895055937C2778283404 @default.
• W2895055937 hasConceptScore W2895055937C2779134260 @default.
• W2895055937 hasConceptScore W2895055937C2780479503 @default.

• next