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- W2895060420 abstract "Abstract Molecules involved in WNT/β-catenin signaling show spatiotemporal-specific expression and play vital roles in muscle development. Our previous study showed that WNT/β-catenin signaling promotes myoblast proliferation and differentiation through the regulation of the cyclin A2 ( Ccna2 )/cell division cycle 25C ( Cdc25c ) and Fermitin family homolog 2 ( Fermt2 ) genes, respectively. However, it remains unclear how β-catenin targets different genes from stage to stage during myogenesis. Here, we show that the accessibility of β-catenin to the promoter region of its target genes is regulated by developmental stage-specific histone acetyltransferases (HATs), lysine acetyltransferase 2B (KAT2B), and cAMP-response element-binding protein (CREB)-binding protein (CBP). We found that KAT2B was specifically expressed at the myoblast proliferation stage and formed a complex with β-catenin to induce Ccna2/Cdc25c expression. On the other hand, CBP was specifically expressed during myoblast differentiation and formed a complex with β-catenin to induce Fermt2 expression. Our findings indicate that β-catenin efficiently accesses to its target gene’s promoters by forming a complex with developmental stage-specific acetyltransferases during myogenesis." @default.
- W2895060420 created "2018-10-12" @default.
- W2895060420 creator A5036177715 @default.
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- W2895060420 date "2018-10-10" @default.
- W2895060420 modified "2023-10-15" @default.
- W2895060420 title "The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus" @default.
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- W2895060420 doi "https://doi.org/10.1038/s41598-018-32888-z" @default.
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