FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895064171> ?p ?o ?g. }

• W2895064171 endingPage "18" @default.
• W2895064171 startingPage "9" @default.
• W2895064171 abstract "Isoflurane, an inhalational anesthesia, has frequently been used in pediatric anesthesia. However, research indicates that isoflurane can induce oxidative stress and affect neural and cognitive development. Melatonin, an endogenous hormone that exhibits antioxidant functions, can play a neuroprotective role by activating the PKCα/Nrf2 signaling pathway in response to oxidative stress. This study aims to determine whether the effect of melatonin on isoflurane-induced oxidative stress is related to activation of the PKCα/Nrf2 signaling pathway. Rat pups at postnatal day 7 were treated with control or 1.5% isoflurane for 4 h after pretreatment for 15 min with either melatonin (10 mg/kg i.p.) or 1% ethanol. The hematoxylin and eosin staining and transmission electron microscopic examination were used for observation of histopathology. The oxidative stress-related indicators were detected by using assay kits. The western blotting, immunohistochemistry and immunofluorescence were used to detect the activation of PKCα/Nrf2 signaling pathway. Results showed that isoflurane induced nerve damage in the hippocampus, and melatonin could reduce this injury. Oxidative stress-related indicators suggested that isoflurane can significantly increase reactive oxygen species and malondialdehyde levels, and decrease superoxide dismutase and glutathione activity compared with the control group, whereas melatonin ameliorated these indices. Expression of proteins associated with the PKCα/Nrf2 signaling pathway indicated that the neuroprotective effect of melatonin is related to activation of the PKCα/Nrf2 signaling pathway. These results suggest that the attenuating effect of melatonin on isoflurane-induced oxidative stress is related to activation of the PKCα/Nrf2 signaling pathway. These findings promote further research into underlying mechanisms and effective treatments to attenuate anesthesia neurotoxicity." @default.
• W2895064171 created "2018-10-12" @default.
• W2895064171 creator A5003844435 @default.
• W2895064171 creator A5016951411 @default.
• W2895064171 creator A5023494462 @default.
• W2895064171 creator A5036587630 @default.
• W2895064171 creator A5043992927 @default.
• W2895064171 creator A5066527222 @default.
• W2895064171 creator A5086902484 @default.
• W2895064171 date "2018-10-01" @default.
• W2895064171 modified "2023-10-02" @default.
• W2895064171 title "Effect of melatonin on attenuating the isoflurane-induced oxidative damage is related to PKCα/Nrf2 signaling pathway in developing rats" @default.
• W2895064171 cites W1490878570 @default.
• W2895064171 cites W1652692682 @default.
• W2895064171 cites W1785455093 @default.
• W2895064171 cites W1970607869 @default.
• W2895064171 cites W1973141016 @default.
• W2895064171 cites W1984454826 @default.
• W2895064171 cites W1993220534 @default.
• W2895064171 cites W2007961244 @default.
• W2895064171 cites W2025969688 @default.
• W2895064171 cites W2026332580 @default.
• W2895064171 cites W2031661979 @default.
• W2895064171 cites W2042016363 @default.
• W2895064171 cites W2045283564 @default.
• W2895064171 cites W2048879736 @default.
• W2895064171 cites W2049809499 @default.
• W2895064171 cites W2053063855 @default.
• W2895064171 cites W2054744426 @default.
• W2895064171 cites W2065350458 @default.
• W2895064171 cites W2066343710 @default.
• W2895064171 cites W2075466397 @default.
• W2895064171 cites W2075993627 @default.
• W2895064171 cites W2076935230 @default.
• W2895064171 cites W2080131125 @default.
• W2895064171 cites W2080779842 @default.
• W2895064171 cites W2086741532 @default.
• W2895064171 cites W2092578112 @default.
• W2895064171 cites W2099867305 @default.
• W2895064171 cites W2122539177 @default.
• W2895064171 cites W2123488223 @default.
• W2895064171 cites W2124390363 @default.
• W2895064171 cites W2131938020 @default.
• W2895064171 cites W2136150633 @default.
• W2895064171 cites W2139554185 @default.
• W2895064171 cites W2140535675 @default.
• W2895064171 cites W2140594985 @default.
• W2895064171 cites W2141954143 @default.
• W2895064171 cites W2146558971 @default.
• W2895064171 cites W2151368477 @default.
• W2895064171 cites W2161423634 @default.
• W2895064171 cites W2474059368 @default.
• W2895064171 cites W2490564440 @default.
• W2895064171 cites W2534783282 @default.
• W2895064171 cites W2555813252 @default.
• W2895064171 cites W2568273047 @default.
• W2895064171 cites W2590163874 @default.
• W2895064171 cites W2593903478 @default.
• W2895064171 cites W2605837333 @default.
• W2895064171 cites W2608713782 @default.
• W2895064171 cites W2745082050 @default.
• W2895064171 cites W2769946213 @default.
• W2895064171 cites W2775256469 @default.
• W2895064171 cites W2791902074 @default.
• W2895064171 cites W2792519191 @default.
• W2895064171 cites W2793542347 @default.
• W2895064171 cites W2794393148 @default.
• W2895064171 cites W2794502854 @default.
• W2895064171 cites W779172143 @default.
• W2895064171 cites W884477295 @default.
• W2895064171 doi "https://doi.org/10.1016/j.brainresbull.2018.09.018" @default.
• W2895064171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278199" @default.
• W2895064171 hasPublicationYear "2018" @default.
• W2895064171 type Work @default.
• W2895064171 sameAs 2895064171 @default.
• W2895064171 citedByCount "21" @default.
• W2895064171 countsByYear W28950641712019 @default.
• W2895064171 countsByYear W28950641712020 @default.
• W2895064171 countsByYear W28950641712021 @default.
• W2895064171 countsByYear W28950641712022 @default.
• W2895064171 countsByYear W28950641712023 @default.
• W2895064171 crossrefType "journal-article" @default.
• W2895064171 hasAuthorship W2895064171A5003844435 @default.
• W2895064171 hasAuthorship W2895064171A5016951411 @default.
• W2895064171 hasAuthorship W2895064171A5023494462 @default.
• W2895064171 hasAuthorship W2895064171A5036587630 @default.
• W2895064171 hasAuthorship W2895064171A5043992927 @default.
• W2895064171 hasAuthorship W2895064171A5066527222 @default.
• W2895064171 hasAuthorship W2895064171A5086902484 @default.
• W2895064171 hasConcept C126322002 @default.
• W2895064171 hasConcept C134018914 @default.
• W2895064171 hasConcept C185592680 @default.
• W2895064171 hasConcept C25498285 @default.
• W2895064171 hasConcept C2775838275 @default.
• W2895064171 hasConcept C2776151105 @default.
• W2895064171 hasConcept C2776359302 @default.
• W2895064171 hasConcept C2778182776 @default.
• W2895064171 hasConcept C2778401633 @default.

• next