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- W2895064298 abstract "The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis. This review summarizes how Bach1 controls these and other cellular and physiological and pathological processes. Bach1 expression and function differ between different cell types. Thus, therapies designed to manipulate Bach1 expression will need to be tightly controlled and tailored for each specific disease state or cell type." @default.
- W2895064298 created "2018-10-12" @default.
- W2895064298 creator A5004063809 @default.
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- W2895064298 date "2018-10-02" @default.
- W2895064298 modified "2023-10-15" @default.
- W2895064298 title "Bach1: Function, Regulation, and Involvement in Disease" @default.
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- W2895064298 doi "https://doi.org/10.1155/2018/1347969" @default.
- W2895064298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189649" @default.
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- W2895064298 hasPublicationYear "2018" @default.
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