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- W2895067602 abstract "Termination of RNA polymerase II (Pol II) transcription is a key step that is important for 3' end formation of functional mRNA, mRNA release, and Pol II recycling. Even so, the underlying termination mechanism is not yet understood. Here, we demonstrate that the conserved and essential termination factor Seb1 is found on Pol II near the end of the RNA exit channel and the Rpb4/7 stalk. Furthermore, the Seb1 interaction surface with Pol II largely overlaps with that of the elongation factor Spt5. Notably, Seb1 co-transcriptional recruitment is dependent on Spt5 dephosphorylation by the conserved PP1 phosphatase Dis2, which also dephosphorylates threonine 4 within the Pol II heptad repeated C-terminal domain. We propose that Dis2 orchestrates the transition from elongation to termination phase during the transcription cycle by mediating elongation to termination factor exchange and dephosphorylation of Pol II C-terminal domain." @default.
- W2895067602 created "2018-10-12" @default.
- W2895067602 creator A5000915834 @default.
- W2895067602 creator A5003402066 @default.
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- W2895067602 creator A5086476845 @default.
- W2895067602 date "2018-10-01" @default.
- W2895067602 modified "2023-10-12" @default.
- W2895067602 title "Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination" @default.
- W2895067602 cites W1783475379 @default.
- W2895067602 cites W1963837739 @default.
- W2895067602 cites W1964013536 @default.
- W2895067602 cites W1964066978 @default.
- W2895067602 cites W1971361691 @default.
- W2895067602 cites W1976779811 @default.
- W2895067602 cites W1981378173 @default.
- W2895067602 cites W1981915772 @default.
- W2895067602 cites W1981930838 @default.
- W2895067602 cites W1990265320 @default.
- W2895067602 cites W1991366673 @default.
- W2895067602 cites W2003676968 @default.
- W2895067602 cites W2011985459 @default.
- W2895067602 cites W2012466702 @default.
- W2895067602 cites W2013286714 @default.
- W2895067602 cites W2013947447 @default.
- W2895067602 cites W2014285665 @default.
- W2895067602 cites W2016774313 @default.
- W2895067602 cites W2017742433 @default.
- W2895067602 cites W2021489197 @default.
- W2895067602 cites W2025082472 @default.
- W2895067602 cites W2027269573 @default.
- W2895067602 cites W2033244618 @default.
- W2895067602 cites W2033317613 @default.
- W2895067602 cites W2034490095 @default.
- W2895067602 cites W2035751664 @default.
- W2895067602 cites W2036321220 @default.
- W2895067602 cites W2037237823 @default.
- W2895067602 cites W2041638332 @default.
- W2895067602 cites W2049017158 @default.
- W2895067602 cites W2051395003 @default.
- W2895067602 cites W2052928602 @default.
- W2895067602 cites W2053706533 @default.
- W2895067602 cites W2057228860 @default.
- W2895067602 cites W2058262378 @default.
- W2895067602 cites W2061519290 @default.
- W2895067602 cites W2062712010 @default.
- W2895067602 cites W2071340829 @default.
- W2895067602 cites W2074206760 @default.
- W2895067602 cites W2074304165 @default.
- W2895067602 cites W2074661080 @default.
- W2895067602 cites W2075191726 @default.
- W2895067602 cites W2076283119 @default.
- W2895067602 cites W2076825429 @default.
- W2895067602 cites W2080587896 @default.
- W2895067602 cites W2080752012 @default.
- W2895067602 cites W2081180101 @default.
- W2895067602 cites W2086949060 @default.
- W2895067602 cites W2090687602 @default.
- W2895067602 cites W2094398789 @default.
- W2895067602 cites W2096978937 @default.
- W2895067602 cites W2099034328 @default.
- W2895067602 cites W2101559095 @default.
- W2895067602 cites W2108234281 @default.
- W2895067602 cites W2114302771 @default.
- W2895067602 cites W2121407329 @default.
- W2895067602 cites W2123540119 @default.
- W2895067602 cites W2126370137 @default.
- W2895067602 cites W2130535660 @default.
- W2895067602 cites W2132629607 @default.
- W2895067602 cites W2136067498 @default.
- W2895067602 cites W2143488845 @default.
- W2895067602 cites W2150541721 @default.
- W2895067602 cites W2162082053 @default.
- W2895067602 cites W2166494447 @default.
- W2895067602 cites W2166829841 @default.
- W2895067602 cites W2170551349 @default.
- W2895067602 cites W2273249288 @default.
- W2895067602 cites W2274600402 @default.
- W2895067602 cites W2299402784 @default.
- W2895067602 cites W2341539131 @default.
- W2895067602 cites W2372571590 @default.
- W2895067602 cites W2399619985 @default.
- W2895067602 cites W2418692346 @default.
- W2895067602 cites W2463195069 @default.
- W2895067602 cites W2474933363 @default.
- W2895067602 cites W2566261809 @default.
- W2895067602 cites W2594980727 @default.
- W2895067602 cites W2602399405 @default.
- W2895067602 cites W2604961247 @default.
- W2895067602 cites W2609665903 @default.
- W2895067602 cites W2610933216 @default.
- W2895067602 cites W2620766554 @default.