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- W2895067685 abstract "Background: Patients with synchronous colorectal liver metastases (sCRLM) are increasingly operated with liver resection. The aim of the present study was to compare outcomes in patients following a simultaneous resection of the primary cancer and the sCRLM and a staged resection where the bowel is resected first and the sCRLM are resected at second stage (classical approach), using data from two nationwide registries in Sweden. Methods: In this retrospective cohort study, clinical, pathological and survival outcomes were compared between the simultaneous approach and the classical approach (2008-2015). Overall survival was calculated. Results: A total of 537 patients were identified, of which 160 were treated with the simultaneous approach and 377 with the classical approach. The median follow-up was 41 months. The patients chosen for the simultaneous approach had more often node-positive primaries (87% vs 63%, p< 0.001), colon primary (78% vs 69%, p=0.046), shorter total hospital stay (11 vs 15 days, p< 0.001) and more often minor liver procedures (84% vs 59%, p< 0.001). The tumour burden score in the liver was the same (P=0.450). There was no difference in 5-year overall survival (p=0.110). A total of 25 patients had a major resection in the simultaneous group and 155 in the classical approach group. No 5-year overall survival difference was shown (P=0.198). Discussion: No difference in overall survival was noted between the strategies. The simultaneous approach appears to be safe even when evaluating major liver resection and primary tumour resection." @default.
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- W2895067685 date "2018-09-01" @default.
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- W2895067685 title "Simultaneous procedures for colorectal cancers with liver metastases, with a special focus on major liver resections" @default.
- W2895067685 doi "https://doi.org/10.1016/j.hpb.2018.06.2601" @default.
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