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• W2895067807 abstract "Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and, together with rabies, a major health burden in West Africa. Here we present the development and characterization of an inactivated recombinant LASV and rabies vaccine candidate (LASSARAB) that expresses a codon-optimized LASV glycoprotein (coGPC) and is adjuvanted by a TLR-4 agonist (GLA-SE). LASSARAB elicits lasting humoral response against LASV and RABV in both mouse and guinea pig models, and it protects both guinea pigs and mice against LF. We also demonstrate a previously unexplored role for non-neutralizing LASV GPC-specific antibodies as a major mechanism of protection by LASSARAB against LF through antibody-dependent cellular functions. Overall, these findings demonstrate an effective inactivated LF vaccine and elucidate a novel humoral correlate of protection for LF." @default.
• W2895067807 created "2018-10-12" @default.
• W2895067807 creator A5011193563 @default.
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• W2895067807 date "2018-10-11" @default.
• W2895067807 modified "2023-10-14" @default.
• W2895067807 title "Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever" @default.
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• W2895067807 doi "https://doi.org/10.1038/s41467-018-06741-w" @default.
• W2895067807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181965" @default.
• W2895067807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310067" @default.
• W2895067807 hasPublicationYear "2018" @default.
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