Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895069899> ?p ?o ?g. }
- W2895069899 endingPage "356" @default.
- W2895069899 startingPage "339" @default.
- W2895069899 abstract "A series of H2SCO dual-donors [Mn(CO)4CS2NR1R2] was synthesized, and evaluated from toxicity and bioactivity. The COH2S measuring test showed all the complexes not only released CO, but released H2S. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A1-A22 had almost no activities against all five tumor cell lines and W138 cell line proliferation. It is worth noting that complex 1 displayed the highest activity to MCF-7, complex 2 displayed the highest activity to HePG2, and complex 7 showed selectivity inhibition to both A549 and HeLa. The developmental toxicities of the complex were assessed using zebrafish embryos. The results showed complexes 1 and 2 had effect on the mortality and hatching rate of zebrafish embryos in dose-dependent manner. They caused zebrafish malformations when they were over 10 μM. Meanwhile, they displayed dose-dependent toxicities to larval zebrafish. In the test of bio-activities, complexes 1 and 2 had strong anti-inflammatory activities; they not only down-regulated the expression levels of iNOS and TNF-α, up-regulated the expression of HO-1 and IL-10, but also up-regulated COX-2 levels. In contrast, the precursor compound (A1 or A2) displayed lower anti-inflammatory activity than the corresponding complex, which suggests both the CO and H2S from the complex took synergistic effects in the process of anti-inflammation. In addition, the complex showed antihypertensive effect and myocardial protection. This effect also possibly resulted from this synergistic effect. All these suggest the complexes have potential to be candidate medicines." @default.
- W2895069899 created "2018-10-12" @default.
- W2895069899 creator A5017577343 @default.
- W2895069899 creator A5026485239 @default.
- W2895069899 creator A5026685623 @default.
- W2895069899 creator A5026717736 @default.
- W2895069899 creator A5038042341 @default.
- W2895069899 creator A5042376958 @default.
- W2895069899 creator A5048314022 @default.
- W2895069899 creator A5048826252 @default.
- W2895069899 creator A5052304188 @default.
- W2895069899 creator A5053942013 @default.
- W2895069899 creator A5063085364 @default.
- W2895069899 date "2018-11-01" @default.
- W2895069899 modified "2023-10-14" @default.
- W2895069899 title "Synthesis, toxicities and bio-activities of manganese complexes with CO and H2S dual donors" @default.
- W2895069899 cites W1488365705 @default.
- W2895069899 cites W1600690434 @default.
- W2895069899 cites W1971666015 @default.
- W2895069899 cites W1980654031 @default.
- W2895069899 cites W1987696062 @default.
- W2895069899 cites W1995726976 @default.
- W2895069899 cites W2002360764 @default.
- W2895069899 cites W2004712996 @default.
- W2895069899 cites W2006524254 @default.
- W2895069899 cites W2006861037 @default.
- W2895069899 cites W2014751211 @default.
- W2895069899 cites W2016901103 @default.
- W2895069899 cites W2018035230 @default.
- W2895069899 cites W2019852356 @default.
- W2895069899 cites W2028612768 @default.
- W2895069899 cites W2030238021 @default.
- W2895069899 cites W2030834862 @default.
- W2895069899 cites W2038173910 @default.
- W2895069899 cites W2063547940 @default.
- W2895069899 cites W2073675064 @default.
- W2895069899 cites W2095002839 @default.
- W2895069899 cites W2121319413 @default.
- W2895069899 cites W2145628829 @default.
- W2895069899 cites W2331429729 @default.
- W2895069899 cites W2334402061 @default.
- W2895069899 cites W2434094369 @default.
- W2895069899 cites W2463301769 @default.
- W2895069899 cites W2494343195 @default.
- W2895069899 cites W4234895519 @default.
- W2895069899 doi "https://doi.org/10.1016/j.ejmech.2018.10.004" @default.
- W2895069899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30308409" @default.
- W2895069899 hasPublicationYear "2018" @default.
- W2895069899 type Work @default.
- W2895069899 sameAs 2895069899 @default.
- W2895069899 citedByCount "10" @default.
- W2895069899 countsByYear W28950698992019 @default.
- W2895069899 countsByYear W28950698992020 @default.
- W2895069899 countsByYear W28950698992022 @default.
- W2895069899 countsByYear W28950698992023 @default.
- W2895069899 crossrefType "journal-article" @default.
- W2895069899 hasAuthorship W2895069899A5017577343 @default.
- W2895069899 hasAuthorship W2895069899A5026485239 @default.
- W2895069899 hasAuthorship W2895069899A5026685623 @default.
- W2895069899 hasAuthorship W2895069899A5026717736 @default.
- W2895069899 hasAuthorship W2895069899A5038042341 @default.
- W2895069899 hasAuthorship W2895069899A5042376958 @default.
- W2895069899 hasAuthorship W2895069899A5048314022 @default.
- W2895069899 hasAuthorship W2895069899A5048826252 @default.
- W2895069899 hasAuthorship W2895069899A5052304188 @default.
- W2895069899 hasAuthorship W2895069899A5053942013 @default.
- W2895069899 hasAuthorship W2895069899A5063085364 @default.
- W2895069899 hasConcept C104317684 @default.
- W2895069899 hasConcept C109316439 @default.
- W2895069899 hasConcept C1491633281 @default.
- W2895069899 hasConcept C178790620 @default.
- W2895069899 hasConcept C185592680 @default.
- W2895069899 hasConcept C193042331 @default.
- W2895069899 hasConcept C202751555 @default.
- W2895069899 hasConcept C2776878037 @default.
- W2895069899 hasConcept C2777366897 @default.
- W2895069899 hasConcept C29730261 @default.
- W2895069899 hasConcept C54355233 @default.
- W2895069899 hasConcept C55493867 @default.
- W2895069899 hasConcept C62112901 @default.
- W2895069899 hasConcept C71240020 @default.
- W2895069899 hasConcept C81885089 @default.
- W2895069899 hasConcept C86803240 @default.
- W2895069899 hasConcept C98274493 @default.
- W2895069899 hasConceptScore W2895069899C104317684 @default.
- W2895069899 hasConceptScore W2895069899C109316439 @default.
- W2895069899 hasConceptScore W2895069899C1491633281 @default.
- W2895069899 hasConceptScore W2895069899C178790620 @default.
- W2895069899 hasConceptScore W2895069899C185592680 @default.
- W2895069899 hasConceptScore W2895069899C193042331 @default.
- W2895069899 hasConceptScore W2895069899C202751555 @default.
- W2895069899 hasConceptScore W2895069899C2776878037 @default.
- W2895069899 hasConceptScore W2895069899C2777366897 @default.
- W2895069899 hasConceptScore W2895069899C29730261 @default.
- W2895069899 hasConceptScore W2895069899C54355233 @default.
- W2895069899 hasConceptScore W2895069899C55493867 @default.
- W2895069899 hasConceptScore W2895069899C62112901 @default.
- W2895069899 hasConceptScore W2895069899C71240020 @default.