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• W2895070168 abstract "Background: Quinolines represent an important class of bioactive molecules which are present in various synthetic drugs, biologically active natural compounds and pharmaceuticals. Quinolines find their potential applications in various chemical and biomedical fields. Thereby, the demand for more efficient and simple methodologies for the synthesis of quinolines is growing rapidly. </P><P> Objective: The green one-pot Friedlander Synthesis of Functionalized Quinolines has been demonstrated by using graphene oxide as a carbocatalyst. </P><P> Method: The graphene oxide catalyzed condensation reaction of 2–aminoaryl carbonyl compounds with different cyclic/ acyclic/ aromatic carbonyl compounds in methanol at 70°C affords different quinoline derivatives. </P><P> Results: The reaction has been examined in different protic and aprotic solvents and the best yield of quinoline is observed in methanol at 70°C. Conclusion: The present method of quinoline synthesis offers various advantages over other reported methods such as short reaction time, high yield of product, recycling of catalyst and simple separation procedure. The graphene oxide carbocatalyst can be easily recovered from the reaction mixture by centrifugation and then can be reused several times without any significant loss in its activity." @default.
• W2895070168 created "2018-10-12" @default.
• W2895070168 creator A5002025135 @default.
• W2895070168 creator A5003973807 @default.
• W2895070168 creator A5077626632 @default.
• W2895070168 date "2019-02-04" @default.
• W2895070168 modified "2023-10-08" @default.
• W2895070168 title "Facile One-Pot Friedlander Synthesis of Functionalized Quinolines using Graphene Oxide Carbocatalyst" @default.
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• W2895070168 doi "https://doi.org/10.2174/1570179415666181002114621" @default.
• W2895070168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31965929" @default.
• W2895070168 hasPublicationYear "2019" @default.
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