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- W2895072442 abstract "Salidroside, a bioactive constituent isolated from Rhodiola rosea, has been reported to have anti-inflammatory effects. However, the effects of salidroside on interleukin (IL)-1β-stimulated osteoarthritis (OA) chondrocytes remain to be elucidated. Thus, this study aimed to evaluate the anti-inflammatory effects of salidroside on IL-1β-stimulated human OA chondrocytes and explore its underlying mechanisms. Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1β-stimulated chondrocytes ( P < .05). In addition, salidroside also suppressed IL-1β-induced matrix metalloproteinases production in human OA chondrocytes ( P < .05). Furthermore, pretreatment with salidroside prevented IL-1β-induced NF-κB activation in OA chondrocytes ( P < .05). In conclusion, the current study demonstrated that salidroside inhibited the IL-1β-induced inflammatory response in OA chondrocytes via inhibition of NF-κB activation." @default.
- W2895072442 created "2018-10-12" @default.
- W2895072442 creator A5011428140 @default.
- W2895072442 creator A5031767581 @default.
- W2895072442 date "2018-09-30" @default.
- W2895072442 modified "2023-10-16" @default.
- W2895072442 title "Salidroside attenuates interleukin‐1β‐induced inflammation in human osteoarthritis chondrocytes" @default.
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- W2895072442 doi "https://doi.org/10.1002/jcb.27076" @default.
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