FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895074295> ?p ?o ?g. }

• W2895074295 abstract "Immunoscore, as a prognostic tool defined to quantify in situ immune cell infiltrates, appears to be superior to the TNM staging system. In esophageal squamous cell carcinoma (ESCC), no immunoscore has been established; however, in situ tumor immunology is recognized as highly important. Our study aimed to construct a comprehensive immunoprofile for ESCC.The infiltration of four immune cell types (CD8+/CD4+/Foxp3+/CD33+ cells), the expression of both inhibitory (PD-1/PD-L1/Tim-3/LAG-3) and stimulatory checkpoints (OX-40/ICOS), and IDO1 were evaluated by IHC staining and multi-color immunofluorescence in two independent cohorts (95 patients in the primary cohort and 55 patients in the validation cohort). The association with patients' overall survival was analyzed by the Kaplan-Meier method and the Cox model. Nomogram-based immunoprofile was established using the independent prognostic variables. To determine its predictive accuracy and discriminatory capacity, the C-index and calibration curve were calculated.Significant correlation of PD-L1 expression in tumor cells with PD-1+ T cell infiltration was found (P = 0.035), indicating the activation of the inhibitory PD-1/PD-L1 pathway in ESCC cases. More PD-L1+ ICs, Tim-3+ ICs and LAG-3+ ICs were found in the CD8-rich tumor microenvironment, which is in accordance with the feedback nature of immune system. After adjustment by TNM stage, four immune variables including the infiltration of CD8+/Foxp3+/CD33+ cells and the PD-L1 expression by tumor cells were selected to construct a prognostic nomogram. The calibration curves showed good accuracy of the nomogram for survival prediction. To overcome the complexity of applying a nomogram in a clinical setting, a simple immunoprofile was then established according to the points of each factor from the nomogram. Our immunoprofile model could separate same-stage patients into different risk subgroups, and showed superior accuracy for survival prediction than the TNM staging system based on the C-index calculation and ROC analysis.Our nomogram-based immunoprofile can provide more accurate prognosis prediction and is an important complement to the TNM staging system for operable ESCC patients." @default.
• W2895074295 created "2018-10-12" @default.
• W2895074295 creator A5005744364 @default.
• W2895074295 creator A5013101547 @default.
• W2895074295 creator A5020515025 @default.
• W2895074295 creator A5037581443 @default.
• W2895074295 creator A5046525642 @default.
• W2895074295 creator A5055770655 @default.
• W2895074295 creator A5067865085 @default.
• W2895074295 creator A5069028088 @default.
• W2895074295 creator A5079594267 @default.
• W2895074295 date "2018-10-03" @default.
• W2895074295 modified "2023-10-18" @default.
• W2895074295 title "A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy" @default.
• W2895074295 cites W1566117310 @default.
• W2895074295 cites W1767508090 @default.
• W2895074295 cites W1859257957 @default.
• W2895074295 cites W1889335134 @default.
• W2895074295 cites W1921303390 @default.
• W2895074295 cites W1981876938 @default.
• W2895074295 cites W2002094191 @default.
• W2895074295 cites W2060469376 @default.
• W2895074295 cites W2068994108 @default.
• W2895074295 cites W2112121482 @default.
• W2895074295 cites W2112648444 @default.
• W2895074295 cites W2127683481 @default.
• W2895074295 cites W2128035403 @default.
• W2895074295 cites W2130207101 @default.
• W2895074295 cites W2140683554 @default.
• W2895074295 cites W2142300779 @default.
• W2895074295 cites W2150633526 @default.
• W2895074295 cites W2157824068 @default.
• W2895074295 cites W2170137783 @default.
• W2895074295 cites W2272984102 @default.
• W2895074295 cites W2334750499 @default.
• W2895074295 cites W2403400382 @default.
• W2895074295 cites W2419439766 @default.
• W2895074295 cites W2510572197 @default.
• W2895074295 cites W2533098748 @default.
• W2895074295 cites W2559382297 @default.
• W2895074295 cites W2560367415 @default.
• W2895074295 cites W2572174216 @default.
• W2895074295 cites W2596604644 @default.
• W2895074295 cites W2626512221 @default.
• W2895074295 cites W2739648040 @default.
• W2895074295 cites W2767857925 @default.
• W2895074295 cites W2773307121 @default.
• W2895074295 cites W2781664909 @default.
• W2895074295 cites W2790175021 @default.
• W2895074295 cites W2791364631 @default.
• W2895074295 cites W2797675588 @default.
• W2895074295 cites W2799508658 @default.
• W2895074295 cites W2800712256 @default.
• W2895074295 cites W2802137539 @default.
• W2895074295 cites W2802206159 @default.
• W2895074295 cites W4249441028 @default.
• W2895074295 doi "https://doi.org/10.1186/s40425-018-0418-7" @default.
• W2895074295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171172" @default.
• W2895074295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285868" @default.
• W2895074295 hasPublicationYear "2018" @default.
• W2895074295 type Work @default.
• W2895074295 sameAs 2895074295 @default.
• W2895074295 citedByCount "44" @default.
• W2895074295 countsByYear W28950742952019 @default.
• W2895074295 countsByYear W28950742952020 @default.
• W2895074295 countsByYear W28950742952021 @default.
• W2895074295 countsByYear W28950742952022 @default.
• W2895074295 countsByYear W28950742952023 @default.
• W2895074295 crossrefType "journal-article" @default.
• W2895074295 hasAuthorship W2895074295A5005744364 @default.
• W2895074295 hasAuthorship W2895074295A5013101547 @default.
• W2895074295 hasAuthorship W2895074295A5020515025 @default.
• W2895074295 hasAuthorship W2895074295A5037581443 @default.
• W2895074295 hasAuthorship W2895074295A5046525642 @default.
• W2895074295 hasAuthorship W2895074295A5055770655 @default.
• W2895074295 hasAuthorship W2895074295A5067865085 @default.
• W2895074295 hasAuthorship W2895074295A5069028088 @default.
• W2895074295 hasAuthorship W2895074295A5079594267 @default.
• W2895074295 hasBestOaLocation W28950742951 @default.
• W2895074295 hasConcept C126322002 @default.
• W2895074295 hasConcept C142724271 @default.
• W2895074295 hasConcept C143998085 @default.
• W2895074295 hasConcept C146357865 @default.
• W2895074295 hasConcept C151730666 @default.
• W2895074295 hasConcept C167672396 @default.
• W2895074295 hasConcept C193270364 @default.
• W2895074295 hasConcept C203014093 @default.
• W2895074295 hasConcept C204232928 @default.
• W2895074295 hasConcept C2776107976 @default.
• W2895074295 hasConcept C2776808855 @default.
• W2895074295 hasConcept C2777546739 @default.
• W2895074295 hasConcept C2779727006 @default.
• W2895074295 hasConcept C3018130915 @default.
• W2895074295 hasConcept C34626388 @default.
• W2895074295 hasConcept C502942594 @default.
• W2895074295 hasConcept C58471807 @default.
• W2895074295 hasConcept C71924100 @default.
• W2895074295 hasConcept C86803240 @default.
• W2895074295 hasConcept C8891405 @default.
• W2895074295 hasConceptScore W2895074295C126322002 @default.

• next