FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895074874> ?p ?o ?g. }

• W2895074874 abstract "Abstract Hepatic myofibroblasts, activated hepatic stellate cells (HSCs), are the main cell type of extracellular matrix (ECM) deposition during hepatic fibrosis. Aberrant DNA methylation-regulated HSCs activation in liver fibrogenesis has been reported, but the functional roles and mechanisms of DNA methylation in hepatic fibrosis remain to be elucidated. In the present study, reduced representation bisulfite sequencing (RRBS) analysis of primary HSCs revealed hypermethylation patterns in hepatic fibrosis. Interestingly, we found SAD1/UNC84 domain protein-2 (SUN2) gene hypermethylation at CpG sites during liver fibrogenesis in mice with CCl 4 -induced hepatic fibrosis, which was accompanied by low expression of SUN2. In vivo overexpression of SUN2 following adeno-associated virus-9 (AAV9) administration inhibited CCl 4 -induced liver injury and reduced fibrogenesis marker expression. Consistently, in vitro experiments showed that enforced expression of SUN2 suppressed HSCs activation and exerted anti-fibrogenesis effects in TGF-β1-activated HSC-T6 cells. In addition, the signaling mechanisms related to SUN2 expression were investigated in vivo and in vitro. Methyltransferase-3b (DNMT3b) is the principal regulator of SUN2 expression. Mechanistically, inhibition of protein kinase B (AKT) phosphorylation may be a crucial pathway for SUN2-mediated HSCs activation. In conclusion, these findings provide substantial new insights into SUN2 in hepatic fibrosis." @default.
• W2895074874 created "2018-10-12" @default.
• W2895074874 creator A5005103669 @default.
• W2895074874 creator A5015620893 @default.
• W2895074874 creator A5019018136 @default.
• W2895074874 creator A5027835055 @default.
• W2895074874 creator A5036910275 @default.
• W2895074874 creator A5038545320 @default.
• W2895074874 creator A5049692788 @default.
• W2895074874 creator A5052676364 @default.
• W2895074874 creator A5054536226 @default.
• W2895074874 creator A5055680568 @default.
• W2895074874 creator A5061349095 @default.
• W2895074874 creator A5069544834 @default.
• W2895074874 date "2018-10-03" @default.
• W2895074874 modified "2023-10-16" @default.
• W2895074874 title "Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis" @default.
• W2895074874 cites W1568802323 @default.
• W2895074874 cites W1878807841 @default.
• W2895074874 cites W1906235443 @default.
• W2895074874 cites W1965588383 @default.
• W2895074874 cites W1969422002 @default.
• W2895074874 cites W1976809932 @default.
• W2895074874 cites W1995212212 @default.
• W2895074874 cites W2006500779 @default.
• W2895074874 cites W2015094353 @default.
• W2895074874 cites W2030276925 @default.
• W2895074874 cites W2046720664 @default.
• W2895074874 cites W2057217551 @default.
• W2895074874 cites W2060901213 @default.
• W2895074874 cites W2074926914 @default.
• W2895074874 cites W2096567469 @default.
• W2895074874 cites W2104193042 @default.
• W2895074874 cites W2142988890 @default.
• W2895074874 cites W2151791851 @default.
• W2895074874 cites W2151898526 @default.
• W2895074874 cites W2153250619 @default.
• W2895074874 cites W2173474465 @default.
• W2895074874 cites W2194344582 @default.
• W2895074874 cites W2262655396 @default.
• W2895074874 cites W2471768967 @default.
• W2895074874 cites W2527658365 @default.
• W2895074874 cites W2553373758 @default.
• W2895074874 cites W2560785495 @default.
• W2895074874 cites W2599606537 @default.
• W2895074874 cites W2615404805 @default.
• W2895074874 cites W2766375505 @default.
• W2895074874 cites W2789487989 @default.
• W2895074874 cites W2794128955 @default.
• W2895074874 cites W4255712601 @default.
• W2895074874 cites W2791240120 @default.
• W2895074874 doi "https://doi.org/10.1038/s41419-018-1032-9" @default.
• W2895074874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170444" @default.
• W2895074874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282980" @default.
• W2895074874 hasPublicationYear "2018" @default.
• W2895074874 type Work @default.
• W2895074874 sameAs 2895074874 @default.
• W2895074874 citedByCount "44" @default.
• W2895074874 countsByYear W28950748742019 @default.
• W2895074874 countsByYear W28950748742020 @default.
• W2895074874 countsByYear W28950748742021 @default.
• W2895074874 countsByYear W28950748742022 @default.
• W2895074874 countsByYear W28950748742023 @default.
• W2895074874 crossrefType "journal-article" @default.
• W2895074874 hasAuthorship W2895074874A5005103669 @default.
• W2895074874 hasAuthorship W2895074874A5015620893 @default.
• W2895074874 hasAuthorship W2895074874A5019018136 @default.
• W2895074874 hasAuthorship W2895074874A5027835055 @default.
• W2895074874 hasAuthorship W2895074874A5036910275 @default.
• W2895074874 hasAuthorship W2895074874A5038545320 @default.
• W2895074874 hasAuthorship W2895074874A5049692788 @default.
• W2895074874 hasAuthorship W2895074874A5052676364 @default.
• W2895074874 hasAuthorship W2895074874A5054536226 @default.
• W2895074874 hasAuthorship W2895074874A5055680568 @default.
• W2895074874 hasAuthorship W2895074874A5061349095 @default.
• W2895074874 hasAuthorship W2895074874A5069544834 @default.
• W2895074874 hasBestOaLocation W28950748741 @default.
• W2895074874 hasConcept C104317684 @default.
• W2895074874 hasConcept C134018914 @default.
• W2895074874 hasConcept C142724271 @default.
• W2895074874 hasConcept C150194340 @default.
• W2895074874 hasConcept C176891718 @default.
• W2895074874 hasConcept C185592680 @default.
• W2895074874 hasConcept C190727270 @default.
• W2895074874 hasConcept C2776637226 @default.
• W2895074874 hasConcept C2780559512 @default.
• W2895074874 hasConcept C2993667909 @default.
• W2895074874 hasConcept C33288867 @default.
• W2895074874 hasConcept C502942594 @default.
• W2895074874 hasConcept C552990157 @default.
• W2895074874 hasConcept C55493867 @default.
• W2895074874 hasConcept C71924100 @default.
• W2895074874 hasConcept C86803240 @default.
• W2895074874 hasConcept C95444343 @default.
• W2895074874 hasConcept C98274493 @default.
• W2895074874 hasConceptScore W2895074874C104317684 @default.
• W2895074874 hasConceptScore W2895074874C134018914 @default.
• W2895074874 hasConceptScore W2895074874C142724271 @default.
• W2895074874 hasConceptScore W2895074874C150194340 @default.
• W2895074874 hasConceptScore W2895074874C176891718 @default.

• next