Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895077242> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2895077242 abstract "Lung cancer is among the top causes of cancer-related mortality in men and is the second most common cancer after breast cancer in women. There are approximately 234,030 new cases of lung cancer and 154,050 deaths from lung cancer in 2018 as per the latest American Cancer Society’s report. Alectinib, a more potent orally active tyrosine kinase inhibitor which was approved by the US Food & Drug Administration for anaplastic lymphoma kinase-positive lung adenocarcinoma, has been shown to have a reasonable safety profile when compared with other anaplastic lymphoma kinase-targeted therapy. As per research studies, grade 1 or 2 renal impairment has been reported but grade 4 renal toxicity due to alectinib has not been reported so far. We report a case of acute renal failure caused by alectinib which necessitated emergency dialysis. This is the first case report describing the severe renal toxicity of alectinib. We describe a case of 72-year-old Taiwanese man diagnosed with stage IV anaplastic lymphoma kinase-positive adenocarcinoma of the lung initially treated with crizotinib for over a year, which was switched to alectinib due to disease progression with brain metastasis. Within 6 weeks of starting alectinib, he developed acute renal failure needing emergency dialysis support. His renal failure was secondary to acute tubular necrosis and had a complete reversal within 7–10 days on withdrawing the medication. When he was re-challenged with alectinib, his creatinine started to worsen again which confirmed the renal toxicity of alectinib. This case emphasizes the uncommon adverse effect of the anaplastic lymphoma kinase-targeted therapy alectinib causing acute renal failure manifesting as acute tubular necrosis. Recognition of alectinib nephropathy requires a thorough drug history and knowledge of risk factors that lessen its margin of safety at therapeutic ingestions. Frequent monitoring of renal functions and early nephrology referral significantly reduce the mortality and morbidity of these patients." @default.
- W2895077242 created "2018-10-12" @default.
- W2895077242 creator A5009218109 @default.
- W2895077242 creator A5021193745 @default.
- W2895077242 creator A5050244700 @default.
- W2895077242 creator A5054084028 @default.
- W2895077242 creator A5054831114 @default.
- W2895077242 creator A5065370654 @default.
- W2895077242 date "2018-10-19" @default.
- W2895077242 modified "2023-09-25" @default.
- W2895077242 title "Alectinib (Alecensa)-induced reversible grade IV nephrotoxicity: a case report and review of the literature" @default.
- W2895077242 cites W2010619956 @default.
- W2895077242 cites W2044936103 @default.
- W2895077242 cites W2055402151 @default.
- W2895077242 cites W2125735484 @default.
- W2895077242 cites W2559456795 @default.
- W2895077242 cites W2624310346 @default.
- W2895077242 cites W2624800767 @default.
- W2895077242 cites W2726009805 @default.
- W2895077242 cites W2726054049 @default.
- W2895077242 doi "https://doi.org/10.1186/s13256-018-1849-y" @default.
- W2895077242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6194643" @default.
- W2895077242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30336782" @default.
- W2895077242 hasPublicationYear "2018" @default.
- W2895077242 type Work @default.
- W2895077242 sameAs 2895077242 @default.
- W2895077242 citedByCount "14" @default.
- W2895077242 countsByYear W28950772422018 @default.
- W2895077242 countsByYear W28950772422020 @default.
- W2895077242 countsByYear W28950772422021 @default.
- W2895077242 countsByYear W28950772422022 @default.
- W2895077242 countsByYear W28950772422023 @default.
- W2895077242 crossrefType "journal-article" @default.
- W2895077242 hasAuthorship W2895077242A5009218109 @default.
- W2895077242 hasAuthorship W2895077242A5021193745 @default.
- W2895077242 hasAuthorship W2895077242A5050244700 @default.
- W2895077242 hasAuthorship W2895077242A5054084028 @default.
- W2895077242 hasAuthorship W2895077242A5054831114 @default.
- W2895077242 hasAuthorship W2895077242A5065370654 @default.
- W2895077242 hasBestOaLocation W28950772421 @default.
- W2895077242 hasConcept C117643217 @default.
- W2895077242 hasConcept C121608353 @default.
- W2895077242 hasConcept C126322002 @default.
- W2895077242 hasConcept C143998085 @default.
- W2895077242 hasConcept C2776232967 @default.
- W2895077242 hasConcept C2776256026 @default.
- W2895077242 hasConcept C2779220645 @default.
- W2895077242 hasConcept C2779422266 @default.
- W2895077242 hasConcept C71924100 @default.
- W2895077242 hasConcept C90924648 @default.
- W2895077242 hasConceptScore W2895077242C117643217 @default.
- W2895077242 hasConceptScore W2895077242C121608353 @default.
- W2895077242 hasConceptScore W2895077242C126322002 @default.
- W2895077242 hasConceptScore W2895077242C143998085 @default.
- W2895077242 hasConceptScore W2895077242C2776232967 @default.
- W2895077242 hasConceptScore W2895077242C2776256026 @default.
- W2895077242 hasConceptScore W2895077242C2779220645 @default.
- W2895077242 hasConceptScore W2895077242C2779422266 @default.
- W2895077242 hasConceptScore W2895077242C71924100 @default.
- W2895077242 hasConceptScore W2895077242C90924648 @default.
- W2895077242 hasIssue "1" @default.
- W2895077242 hasLocation W28950772421 @default.
- W2895077242 hasLocation W28950772422 @default.
- W2895077242 hasLocation W28950772423 @default.
- W2895077242 hasLocation W28950772424 @default.
- W2895077242 hasOpenAccess W2895077242 @default.
- W2895077242 hasPrimaryLocation W28950772421 @default.
- W2895077242 hasRelatedWork W2400744927 @default.
- W2895077242 hasRelatedWork W2503069423 @default.
- W2895077242 hasRelatedWork W2516942920 @default.
- W2895077242 hasRelatedWork W2624310346 @default.
- W2895077242 hasRelatedWork W2941535758 @default.
- W2895077242 hasRelatedWork W3035529108 @default.
- W2895077242 hasRelatedWork W3197633853 @default.
- W2895077242 hasRelatedWork W3199005851 @default.
- W2895077242 hasRelatedWork W4226257711 @default.
- W2895077242 hasRelatedWork W4308551119 @default.
- W2895077242 hasVolume "12" @default.
- W2895077242 isParatext "false" @default.
- W2895077242 isRetracted "false" @default.
- W2895077242 magId "2895077242" @default.
- W2895077242 workType "article" @default.