FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895077856> ?p ?o ?g. }

• W2895077856 abstract "ABSTRACT It is well established that GC content varies across the genome in many species and that GC biased gene conversion, one form of meiotic recombination, is likely to contribute to this heterogeneity. Bird genomes provide an extraordinary system to study the impact of GC biased gene conversion owed to their specific genomic features. They are characterised by a high karyotype conservation with substantial heterogeneity in chromosome sizes, with up to a dozen large macrochromosomes and many smaller microchromosomes common across all bird species. This heterogeneity in chromosome morphology is also reflected by other genomic features, such as smaller chromosomes being gene denser, more compact and more GC rich relative to their macrochromosomal counterparts - illustrating that the intensity of GC biased gene conversion varies across the genome. Here we study whether it is possible to infer heterogeneity in GC biased gene conversion rates across the genome using a recently published method that accounts for GC biased gene conversion when estimating branch lengths in a phylogenetic context. To infer the strength of GC biased gene conversion we contrast branch length estimates across the genome both taking and not taking non-stationary GC composition into account. Using simulations we show that this approach works well when GC fixation bias is strong and note that the number of substitutions along a branch is consistently overestimated when GC biased gene conversion is not accounted for. We use this predictable feature to infer the strength of GC dynamics across the great tit genome by applying our new test statistic to data at 4-fold degenerate sites from three bird species - great tit, zebra finch and chicken - three species that are among the best annotated bird genomes to date. We show that using a simple one-dimensional binning we fail to capture a signal of fixation bias as observed in our simulations. However, using a multidimensional binning strategy, we find evidence for heterogeneity in the strength of fixation bias, including AT fixation bias. This highlights the difficulties when combining sequence data across different regions in the genome." @default.
• W2895077856 created "2018-10-12" @default.
• W2895077856 creator A5002965297 @default.
• W2895077856 creator A5017064978 @default.
• W2895077856 creator A5046726569 @default.
• W2895077856 creator A5072104523 @default.
• W2895077856 creator A5082114082 @default.
• W2895077856 date "2018-10-05" @default.
• W2895077856 modified "2023-09-23" @default.
• W2895077856 title "Evidence for strong fixation bias at 4-fold degenerate sites across genes in the great tit genome" @default.
• W2895077856 cites W1510523291 @default.
• W2895077856 cites W1525734744 @default.
• W2895077856 cites W1847769736 @default.
• W2895077856 cites W1916539208 @default.
• W2895077856 cites W1936769609 @default.
• W2895077856 cites W1968471467 @default.
• W2895077856 cites W1975862997 @default.
• W2895077856 cites W1982603712 @default.
• W2895077856 cites W1982906065 @default.
• W2895077856 cites W1996019265 @default.
• W2895077856 cites W2004391041 @default.
• W2895077856 cites W2007074280 @default.
• W2895077856 cites W2009596137 @default.
• W2895077856 cites W2023998798 @default.
• W2895077856 cites W2031524125 @default.
• W2895077856 cites W2038359695 @default.
• W2895077856 cites W2065461553 @default.
• W2895077856 cites W2082967251 @default.
• W2895077856 cites W2095897941 @default.
• W2895077856 cites W2100238259 @default.
• W2895077856 cites W2102424972 @default.
• W2895077856 cites W2110335151 @default.
• W2895077856 cites W2121043033 @default.
• W2895077856 cites W2142635246 @default.
• W2895077856 cites W2143699138 @default.
• W2895077856 cites W2144934389 @default.
• W2895077856 cites W2145865133 @default.
• W2895077856 cites W2148960006 @default.
• W2895077856 cites W2155575747 @default.
• W2895077856 cites W2157009009 @default.
• W2895077856 cites W2157552136 @default.
• W2895077856 cites W2161066156 @default.
• W2895077856 cites W2161621793 @default.
• W2895077856 cites W2163600007 @default.
• W2895077856 cites W2167406239 @default.
• W2895077856 cites W2170158882 @default.
• W2895077856 cites W2175352995 @default.
• W2895077856 cites W2178459208 @default.
• W2895077856 cites W2272717953 @default.
• W2895077856 cites W2748827512 @default.
• W2895077856 cites W2753532849 @default.
• W2895077856 cites W2780518010 @default.
• W2895077856 cites W2883611464 @default.
• W2895077856 cites W2888373299 @default.
• W2895077856 cites W2950653175 @default.
• W2895077856 cites W2951819183 @default.
• W2895077856 cites W4292239814 @default.
• W2895077856 doi "https://doi.org/10.1101/436618" @default.
• W2895077856 hasPublicationYear "2018" @default.
• W2895077856 type Work @default.
• W2895077856 sameAs 2895077856 @default.
• W2895077856 citedByCount "0" @default.
• W2895077856 crossrefType "posted-content" @default.
• W2895077856 hasAuthorship W2895077856A5002965297 @default.
• W2895077856 hasAuthorship W2895077856A5017064978 @default.
• W2895077856 hasAuthorship W2895077856A5046726569 @default.
• W2895077856 hasAuthorship W2895077856A5072104523 @default.
• W2895077856 hasAuthorship W2895077856A5082114082 @default.
• W2895077856 hasBestOaLocation W28950778561 @default.
• W2895077856 hasConcept C104317684 @default.
• W2895077856 hasConcept C112212490 @default.
• W2895077856 hasConcept C141231307 @default.
• W2895077856 hasConcept C146249460 @default.
• W2895077856 hasConcept C163096569 @default.
• W2895077856 hasConcept C174600577 @default.
• W2895077856 hasConcept C190172338 @default.
• W2895077856 hasConcept C193252679 @default.
• W2895077856 hasConcept C30481170 @default.
• W2895077856 hasConcept C42251679 @default.
• W2895077856 hasConcept C53226629 @default.
• W2895077856 hasConcept C54355233 @default.
• W2895077856 hasConcept C78458016 @default.
• W2895077856 hasConcept C86803240 @default.
• W2895077856 hasConceptScore W2895077856C104317684 @default.
• W2895077856 hasConceptScore W2895077856C112212490 @default.
• W2895077856 hasConceptScore W2895077856C141231307 @default.
• W2895077856 hasConceptScore W2895077856C146249460 @default.
• W2895077856 hasConceptScore W2895077856C163096569 @default.
• W2895077856 hasConceptScore W2895077856C174600577 @default.
• W2895077856 hasConceptScore W2895077856C190172338 @default.
• W2895077856 hasConceptScore W2895077856C193252679 @default.
• W2895077856 hasConceptScore W2895077856C30481170 @default.
• W2895077856 hasConceptScore W2895077856C42251679 @default.
• W2895077856 hasConceptScore W2895077856C53226629 @default.
• W2895077856 hasConceptScore W2895077856C54355233 @default.
• W2895077856 hasConceptScore W2895077856C78458016 @default.
• W2895077856 hasConceptScore W2895077856C86803240 @default.
• W2895077856 hasLocation W28950778561 @default.
• W2895077856 hasLocation W28950778562 @default.
• W2895077856 hasLocation W28950778563 @default.

• next