Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895079131> ?p ?o ?g. }
- W2895079131 startingPage "438135" @default.
- W2895079131 abstract "Abstract Plants prioritize growth over defense to gain a competitive advantage for limited resources, but change priorities to successfully fight infection and herbivory. Despite the importance of growth-defense tradeoffs in optimizing plant productivity in natural and agricultural populations, the molecular mechanisms that link growth and immunity remain unclear. Here, we demonstrate that growth-defense tradeoffs between pathways activated by BRI1, a steroid receptor, and FLS2, an innate immune receptor, are uncoupled in an Arabidopsis mutant (agg1 agg2) lacking two redundant heterotrimeric G-protein gamma subunits that form stable heterodimers with the Gβ subunit AGB1 to control one arm of the unfolded protein response (UPR) independently of ER stress. Growth inhibition from induced immunity in wild-type plants is likely caused by AGB1-AGG1/2 dimers interacting with nascent BRI1 and FLS2 proteins on the endoplasmic reticulum (ER) membrane and repressing an UPR response that is hardwired to promote BRI1 protein biogenesis and FLS2 protein degradation via autophagy. The ability to unlock and fine-tune growth-defense tradeoffs through UPR signaling provides a novel strategy to increase the natural defenses of crops while maintaining optimal plant productivity." @default.
- W2895079131 created "2018-10-12" @default.
- W2895079131 creator A5007031720 @default.
- W2895079131 creator A5048566011 @default.
- W2895079131 creator A5053774439 @default.
- W2895079131 creator A5077400042 @default.
- W2895079131 creator A5085480865 @default.
- W2895079131 date "2018-10-08" @default.
- W2895079131 modified "2023-09-23" @default.
- W2895079131 title "Heterotrimeric G-proteins in unfolded protein response mediate plant growth-defense tradeoffs upstream of steroid and immune signaling" @default.
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