FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895079804> ?p ?o ?g. }

• W2895079804 endingPage "268" @default.
• W2895079804 startingPage "256" @default.
• W2895079804 abstract "Bone marrow mesenchymal stem/stromal cells (MSCs) maintain bone homeostasis and repair through the ability to expand in response to mitotic stimuli and differentiate into skeletal lineages. Signalling mechanisms that enable precise control of MSC function remain unclear. Here we report that by initially examining differences in signalling pathway expression profiles of individual MSC clones, we identified a previously unrecognised signalling mechanism regulated by epidermal growth factor (EGF) in primary human MSCs. We demonstrate that EGF is able to activate β-catenin, a key component of the canonical Wnt signalling pathway. EGF is able to induce nuclear translocation of β-catenin in human MSCs but does not drive expression of Wnt target genes or T cell factor (TCF) activity in MSC reporter cell lines. Using an efficient Design of Experiments (DoE) statistical analysis, with different combinations and concentrations of EGF and Wnt ligands, we were able to confirm that EGF does not influence the Wnt/β-catenin pathway in MSCs. We show that the effects of EGF on MSCs are temporally regulated to initiate early “classical” EGF signalling mechanisms (e.g via mitogen activated protein kinase) with delayed activation of β-catenin. By RNA-sequencing, we identified gene sets that were exclusively regulated by the EGF/β-catenin pathway, which were distinct from classical EGF-regulated genes. However, subsets of classical EGF gene targets were significantly influenced by EGF/β-catenin activation. These signalling pathways cooperate to enable EGF-mediated proliferation of MSCs by alleviating the suppression of cell cycle pathways induced by classical EGF signalling." @default.
• W2895079804 created "2018-10-12" @default.
• W2895079804 creator A5001189780 @default.
• W2895079804 creator A5017947232 @default.
• W2895079804 creator A5031924538 @default.
• W2895079804 creator A5036607077 @default.
• W2895079804 creator A5051591101 @default.
• W2895079804 creator A5060339009 @default.
• W2895079804 creator A5066623637 @default.
• W2895079804 creator A5069857310 @default.
• W2895079804 date "2019-01-01" @default.
• W2895079804 modified "2023-09-27" @default.
• W2895079804 title "Epidermal growth factor can signal via β-catenin to control proliferation of mesenchymal stem cells independently of canonical Wnt signalling" @default.
• W2895079804 cites W1480006702 @default.
• W2895079804 cites W1987575163 @default.
• W2895079804 cites W1989485116 @default.
• W2895079804 cites W1989597367 @default.
• W2895079804 cites W1991162692 @default.
• W2895079804 cites W2000682075 @default.
• W2895079804 cites W2011033752 @default.
• W2895079804 cites W2012095617 @default.
• W2895079804 cites W2014129405 @default.
• W2895079804 cites W2014362480 @default.
• W2895079804 cites W2020903392 @default.
• W2895079804 cites W2023099007 @default.
• W2895079804 cites W2025553912 @default.
• W2895079804 cites W2026344731 @default.
• W2895079804 cites W2028955152 @default.
• W2895079804 cites W2029143606 @default.
• W2895079804 cites W2029187758 @default.
• W2895079804 cites W2030774127 @default.
• W2895079804 cites W2034887444 @default.
• W2895079804 cites W2036897871 @default.
• W2895079804 cites W2054510931 @default.
• W2895079804 cites W2056607822 @default.
• W2895079804 cites W2076587628 @default.
• W2895079804 cites W2080000503 @default.
• W2895079804 cites W2081666285 @default.
• W2895079804 cites W2082387343 @default.
• W2895079804 cites W2087124418 @default.
• W2895079804 cites W2089822623 @default.
• W2895079804 cites W2089833292 @default.
• W2895079804 cites W2098706786 @default.
• W2895079804 cites W2100070586 @default.
• W2895079804 cites W2100305481 @default.
• W2895079804 cites W2102278945 @default.
• W2895079804 cites W2106204137 @default.
• W2895079804 cites W2106316818 @default.
• W2895079804 cites W2109130669 @default.
• W2895079804 cites W2118719170 @default.
• W2895079804 cites W2119413986 @default.
• W2895079804 cites W2121841798 @default.
• W2895079804 cites W2130410032 @default.
• W2895079804 cites W2138081474 @default.
• W2895079804 cites W2138153315 @default.
• W2895079804 cites W2145915228 @default.
• W2895079804 cites W2146138547 @default.
• W2895079804 cites W2150244958 @default.
• W2895079804 cites W2159999899 @default.
• W2895079804 cites W2162287935 @default.
• W2895079804 cites W2167283281 @default.
• W2895079804 cites W2281423066 @default.
• W2895079804 doi "https://doi.org/10.1016/j.cellsig.2018.09.021" @default.
• W2895079804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6293317" @default.
• W2895079804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287279" @default.
• W2895079804 hasPublicationYear "2019" @default.
• W2895079804 type Work @default.
• W2895079804 sameAs 2895079804 @default.
• W2895079804 citedByCount "15" @default.
• W2895079804 countsByYear W28950798042019 @default.
• W2895079804 countsByYear W28950798042020 @default.
• W2895079804 countsByYear W28950798042021 @default.
• W2895079804 countsByYear W28950798042022 @default.
• W2895079804 countsByYear W28950798042023 @default.
• W2895079804 crossrefType "journal-article" @default.
• W2895079804 hasAuthorship W2895079804A5001189780 @default.
• W2895079804 hasAuthorship W2895079804A5017947232 @default.
• W2895079804 hasAuthorship W2895079804A5031924538 @default.
• W2895079804 hasAuthorship W2895079804A5036607077 @default.
• W2895079804 hasAuthorship W2895079804A5051591101 @default.
• W2895079804 hasAuthorship W2895079804A5060339009 @default.
• W2895079804 hasAuthorship W2895079804A5066623637 @default.
• W2895079804 hasAuthorship W2895079804A5069857310 @default.
• W2895079804 hasBestOaLocation W28950798041 @default.
• W2895079804 hasConcept C137620995 @default.
• W2895079804 hasConcept C198826908 @default.
• W2895079804 hasConcept C2776362946 @default.
• W2895079804 hasConcept C2779324961 @default.
• W2895079804 hasConcept C28328180 @default.
• W2895079804 hasConcept C30145163 @default.
• W2895079804 hasConcept C54355233 @default.
• W2895079804 hasConcept C62478195 @default.
• W2895079804 hasConcept C81885089 @default.
• W2895079804 hasConcept C86803240 @default.
• W2895079804 hasConcept C88498014 @default.
• W2895079804 hasConcept C95444343 @default.
• W2895079804 hasConceptScore W2895079804C137620995 @default.
• W2895079804 hasConceptScore W2895079804C198826908 @default.

• next