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- W2895079873 abstract "The current work is designed to explore the hepatoameliorative impacts of silymarin and ethanolic extract of jasonia montana versus bisphenol A (BPA) induced hepatotoxicity in a time dependent manner. Rats were allocated into five groups as follows; Group i: rats orally received Propylene glycol (1ml/kg B.W/day), served as control. Groups ii: rats orally receivedPropylene glycol for 2 weeks, then received BPA (50 mg/kg) in Propylene glycol. Groups iii-v: rats orally received (Silymarin, Jasonia Montana , both herbs) (200 mg/kg bw,150 mg/kgB.W/day, both doses) respectively for 2 weeks, then administeredBPA in combination with herbs for 6 weeks. BPA induced hepatotoxicity as confirmed by increased liver enzyme leakage, hepatic 4-HNE, reduced TAC activity, IGF-1 and GSH-PX, GST gene expression. Further, BPA evoked apoptotic effect as expressed by high hepatic caspase-3 activity, TNF-α level with lower BCL-2 level. As well as fibrotic effect as indicated by increased hepatic TGF-B1 and confirmed by histopathological investigation. On contrary, oral Silymarin and ethanolic extract of jasonia montana supplementation attenuated bisphenol-A evoked alterations in the above-mentioned markers all the experimental periods specially after 8 weeks, meanwhile both herps don’t affect GSH-PX, GST gene expression. Taken together, the present results summarize that J. Montana ethanolic extract supplementation showed hepatoprotctive effects versus bisphenol- induced hepatic toxicity, while silymarin can be served as a novel hepatoprotective medication and combination of both herps was better than each alone due to their synergistic antioxidant properties." @default.
- W2895079873 created "2018-10-12" @default.
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- W2895079873 date "2018-09-20" @default.
- W2895079873 modified "2023-09-25" @default.
- W2895079873 title "SYNERGISTIC HEPATOAMELIORATIVE POTENTIAL OF SILYMARIN AND ETHANOLIC EXTRACT OF JASONIA MONTANA VERSUS BISPHENOL INDUCED HEPATOTOXICITY IN RATS" @default.
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