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• W2895081696 abstract "Hemobilia is a rare cause of upper-GI bleeding that may be secondary to iatrogenic biliary injury, malignancy, or vascular malformations.1Chin M.W. Enns R. Hemobilia.Curr Gastroenterol Rep. 2010; 12: 121-129Crossref PubMed Scopus (50) Google Scholar, 2Abdelfatah M.M. Mudireddy P.R. Hemobilia: a rare cause of intermittent biliary obstruction.VideoGIE. 2018; 8: 236-237Google Scholar ERCP has an established role in both the diagnosis of and the therapy for hemobilia. This recently has been augmented by the introduction of cholangioscopy. We present the case of a 90-year-old woman who presented with biliary obstruction demonstrated by deranged liver function test results and elevated lipase (Table 1). She had multiple comorbidities, including end-stage renal failure (with a baseline estimated glomerular filtration rate of 10 mL/min), congestive cardiac failure, and previous cerebrovascular accident that left her frail and requiring significant assistance. Abdominal CT and US scans demonstrated gallbladder wall thickening with dilated intrahepatic and extrahepatic bile ducts (Fig. 1).Table 1Laboratory results on admission and progressLaboratory testAdmissionDay 3Bilirubin (μmol/L)2386ALP (U/L)693577GGT (U/L)331272ALT (U/L)502257AST (U/L)1006168Lipase (U/L)>3000Hemoglobin (g/L)9968Creatinine (μmol/L)333321eGFR (mL/min)1010ALP, Alkaline phosphatase; GGT, γ-glutamyltransferase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; eGFR, estimated glomerular filtration rate. Open table in a new tab ALP, Alkaline phosphatase; GGT, γ-glutamyltransferase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; eGFR, estimated glomerular filtration rate. On day 3 of her admission, the patient experienced melena, with a resultant fall in hemoglobin but a concurrent rise in bilirubin (Table 1). ERCP demonstrated multiple filling defects within a dilated common bile duct (CBD) (Fig. 2). Hemobilia was suspected and confirmed after endoscopic sphincterotomy, and balloon trawl resulted in the clearance of multiple clots. MRI again demonstrated a thickened and poorly defined gallbladder wall, along with an abnormal ill-defined signal that extended into the adjacent part of the liver (Fig. 3). This, in keeping with the results of her other investigations, was highly suggestive of a diffusely infiltrative gallbladder cancer.Figure 3Magnetic resonance imaging view demonstrating (A) thickened and poorly defined gallbladder wall and (B) ill-defined abnormal signal extending into the adjacent part of the liver.View Large Image Figure ViewerDownload Hi-res image Download (PPT) The patient’s age and comorbidities precluded definitive therapy for the suspected malignancy. However, she had ongoing clinically significant hemobilia that required transfusion of 6 units of packed red blood cells over 13 days. Other palliative treatment options thus were considered at a multidisciplinary meeting. Her renal function precluded the administration of contrast material for radiologic embolization. Radiotherapy to the gallbladder bed was considered; however, a consensus decision was made for endoscopy with diagnostic cholangioscopy and possible biliary stent placement (Video 1, available online at www.VideoGIE.org). Repeated ERCP with cholangioscopy (Spyglass; Boston Scientific, Marlborough, Mass, USA) was performed to localize the bleeding. Cholangioscopy demonstrated active bleeding arising from the cystic duct orifice (Fig. 4). Direct visualization of the cystic duct revealed further clots. When limited contrast material was introduced, gallbladder filling defects were seen, reflecting either further clots or neoplasm (Fig. 5). With a nondilated CBD (6 mm in diameter), a decision was made to place a fully covered self-expanding metal stent (FCSEMS) (Wallflex; Boston Scientific) to cover the cystic duct origin (Fig. 6). Postprocedure recovery was uneventful, with no further melena and normalization of liver function test results. There were no further bleeding episodes at her 4-month follow-up visit; however, the patient died due to progressive renal failure.Figure 5Filling defects seen in gallbladder.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6Fully covered self-expanding metal stent inserted to overlie the cystic duct.View Large Image Figure ViewerDownload Hi-res image Download (PPT) ERCP and cholangioscopy are effective diagnostic and therapeutic modalities for hemobilia. Other treatment options for hemobilia include surgery and radiologic embolization. In this case, imaging suggested an underlying gallbladder malignancy; however, management options were limited. Cholangioscopy confirmed that the bleeding appeared to arise from the gallbladder. The FCSEMS was placed to occlude the cystic duct orifice, presumably inducing tamponade, and possibly, but less likely, direct tumor or vascular compression. The use of FCSEMSs in malignant biliary obstruction may result in cholecystitis in approximately 8% of patients, particularly in cases of nonhilar strictures with cystic duct occlusion.3Jang S. Stevens T. Parsi M. et al.Association of covered metallic stents with cholecystitis and stent migration in malignant biliary stricture.Gastrointest Endosc. 2018; 87: 1061-1070Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Thus, we attempted to mitigate the risk of cholecystitis with prophylactic antibiotics and by limiting both cholangioscopic irrigation and injection of contrast material into the gallbladder. Significant CBD dilatation would preclude stent placement because FCSEMS migration occurs in approximately 10% of cases.3Jang S. Stevens T. Parsi M. et al.Association of covered metallic stents with cholecystitis and stent migration in malignant biliary stricture.Gastrointest Endosc. 2018; 87: 1061-1070Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Although previous reports describe the use of SEMSs to palliate malignant hemobilia by direct tumor compression,1Chin M.W. Enns R. Hemobilia.Curr Gastroenterol Rep. 2010; 12: 121-129Crossref PubMed Scopus (50) Google Scholar, 4Kawaguchi Y. Ogawa M. Maruno A. et al.A case of successful placement of a fully covered metallic stent for hemobilia secondary to hepatocellular carcinoma with bile duct invasion.Case Rep Oncol. 2012; 5: 682-686Google Scholar, 5Rerknimitr R. Kongkam P. Kullavanijaya P. Treatment of tumor associated hemobilia with a partially covered metallic stent.Endoscopy. 2007; 39: E225Google Scholar this case used an FCSEMS to control hemobilia arising from the gallbladder. All authors disclosed no financial relationships relevant to this publication. eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI5MWY4MWQzNTA2OThiZWY4ZmY2NjA4Yzg2OTA3NGE5YSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc5NDU1NjczfQ.Y1pcX6YsOo2OMdZI__2vVlrA57s9uJ0SMUyVsNpc5mZtyQ1xwrhHFQqZ-mabdxTlPsgSzWtA0pqXAjH8CdwZBZQGEaClBK4TYB7Eu4XMWBNYHBLgMHkV-wdWbfw2YPQGe0JToyb8Hmcvcl9Mu2OdpZpROC_uycPx8zXfopNzp3zffGuRp1oFxNxMlprRPg-DYHS9whLfCVx2MlnRH8W6NKl93ySG64FNZQli2QH5f1ib_irqahTR6gdnvMIjGlJ1NBe3doYJBdM3KMwUINoC_uZ0fwtFDGGe3UplQXmW7P4rBeRUWEyeZIh4gJQRGKOVMQ-GMzQk5S-qs0ry4g_ZXw Download .mp4 (140.54 MB) Help with .mp4 files Video 1Hemobilia due to gallbladder cancer diagnosed by cholangioscopy and managed with a fully covered self-expanding metal stent." @default.
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• W2895081696 title "A case of hemobilia secondary to cancer of the gallbladder confirmed by cholangioscopy and treated with a fully covered self-expanding metal stent" @default.
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• W2895081696 doi "https://doi.org/10.1016/j.vgie.2018.08.013" @default.
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