FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895082561> ?p ?o ?g. }

• W2895082561 endingPage "278" @default.
• W2895082561 startingPage "269" @default.
• W2895082561 abstract "Joint neuropathic pain occurs in a subset of arthritis patients, and lysophosphatidic acid (LPA) has been implicated as a mediator of joint neuropathy. The mechanism by which LPA promotes neuropathic pain is unknown but may be related to altered signalling of the voltage-gated sodium channel Nav1.8 located on nociceptors. Because arthritis and neuropathic pain are more prevalent in females, this study aimed to explore potential sex differences in the development of LPA-induced joint neuropathy and whether Nav1.8 played a role in the associated neuropathic pain. Joint neuropathy was induced in male and female Wistar rats (179-284 g) by intra-articular injection of 50-µg LPA. Pain behaviour was assessed over 21 days using von Frey hair algesiometry. On day 21, electrophysiological recordings of joint primary afferents were conducted to measure peripheral sensitisation. Saphenous nerve morphology and expression of the nerve-damage marker ATF3 and Nav1.8 in ipsilateral dorsal root ganglions were compared on the basis of sex. The analgesic properties of the selective Nav1.8 antagonist A-803467 was determined in pain behaviour and electrophysiology experiments. Females developed more severe mechanical allodynia than males after LPA treatment. Lysophosphatidic acid caused more pronounced demyelination of the saphenous nerve in females, but no sex differences were observed in the expression of ATF3 or Nav1.8 in dorsal root ganglion neurones. Blockade of Nav1.8 channels with A-803467 resulted in a decrease in joint mechanosensitivity and secondary allodynia with females exhibiting a greater response. These findings suggest that LPA has sex-specific effects on joint neuropathy and Nav1.8 gating, which should be considered when treating neuropathic arthritis patients." @default.
• W2895082561 created "2018-10-12" @default.
• W2895082561 creator A5004167898 @default.
• W2895082561 creator A5049036561 @default.
• W2895082561 creator A5062308311 @default.
• W2895082561 date "2018-09-11" @default.
• W2895082561 modified "2023-10-14" @default.
• W2895082561 title "Targeting the Nav1.8 ion channel engenders sex-specific responses in lysophosphatidic acid–induced joint neuropathy" @default.
• W2895082561 cites W1605129038 @default.
• W2895082561 cites W1969820383 @default.
• W2895082561 cites W1974905386 @default.
• W2895082561 cites W1978466333 @default.
• W2895082561 cites W1992791643 @default.
• W2895082561 cites W2000492372 @default.
• W2895082561 cites W2005089167 @default.
• W2895082561 cites W2008465842 @default.
• W2895082561 cites W2010313421 @default.
• W2895082561 cites W2011487877 @default.
• W2895082561 cites W2016474170 @default.
• W2895082561 cites W2018368852 @default.
• W2895082561 cites W2023731184 @default.
• W2895082561 cites W2042120969 @default.
• W2895082561 cites W2047734268 @default.
• W2895082561 cites W2047865790 @default.
• W2895082561 cites W2051997075 @default.
• W2895082561 cites W2053340442 @default.
• W2895082561 cites W2071129982 @default.
• W2895082561 cites W2082470319 @default.
• W2895082561 cites W2084708008 @default.
• W2895082561 cites W2087937006 @default.
• W2895082561 cites W2094077164 @default.
• W2895082561 cites W2094162828 @default.
• W2895082561 cites W2107559519 @default.
• W2895082561 cites W2113076341 @default.
• W2895082561 cites W2127894556 @default.
• W2895082561 cites W2129281457 @default.
• W2895082561 cites W2129623136 @default.
• W2895082561 cites W2131442183 @default.
• W2895082561 cites W2149599746 @default.
• W2895082561 cites W2156865105 @default.
• W2895082561 cites W2168261136 @default.
• W2895082561 cites W2172201406 @default.
• W2895082561 cites W2196308323 @default.
• W2895082561 cites W2224283033 @default.
• W2895082561 cites W2510317279 @default.
• W2895082561 cites W2518893499 @default.
• W2895082561 cites W2586911489 @default.
• W2895082561 cites W2594459623 @default.
• W2895082561 cites W2605838753 @default.
• W2895082561 cites W2753676573 @default.
• W2895082561 doi "https://doi.org/10.1097/j.pain.0000000000001399" @default.
• W2895082561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30211781" @default.
• W2895082561 hasPublicationYear "2018" @default.
• W2895082561 type Work @default.
• W2895082561 sameAs 2895082561 @default.
• W2895082561 citedByCount "22" @default.
• W2895082561 countsByYear W28950825612019 @default.
• W2895082561 countsByYear W28950825612020 @default.
• W2895082561 countsByYear W28950825612021 @default.
• W2895082561 countsByYear W28950825612022 @default.
• W2895082561 countsByYear W28950825612023 @default.
• W2895082561 crossrefType "journal-article" @default.
• W2895082561 hasAuthorship W2895082561A5004167898 @default.
• W2895082561 hasAuthorship W2895082561A5049036561 @default.
• W2895082561 hasAuthorship W2895082561A5062308311 @default.
• W2895082561 hasConcept C126322002 @default.
• W2895082561 hasConcept C127413603 @default.
• W2895082561 hasConcept C169760540 @default.
• W2895082561 hasConcept C170154142 @default.
• W2895082561 hasConcept C170493617 @default.
• W2895082561 hasConcept C18555067 @default.
• W2895082561 hasConcept C185592680 @default.
• W2895082561 hasConcept C2776661833 @default.
• W2895082561 hasConcept C50254741 @default.
• W2895082561 hasConcept C71924100 @default.
• W2895082561 hasConcept C86803240 @default.
• W2895082561 hasConcept C95444343 @default.
• W2895082561 hasConceptScore W2895082561C126322002 @default.
• W2895082561 hasConceptScore W2895082561C127413603 @default.
• W2895082561 hasConceptScore W2895082561C169760540 @default.
• W2895082561 hasConceptScore W2895082561C170154142 @default.
• W2895082561 hasConceptScore W2895082561C170493617 @default.
• W2895082561 hasConceptScore W2895082561C18555067 @default.
• W2895082561 hasConceptScore W2895082561C185592680 @default.
• W2895082561 hasConceptScore W2895082561C2776661833 @default.
• W2895082561 hasConceptScore W2895082561C50254741 @default.
• W2895082561 hasConceptScore W2895082561C71924100 @default.
• W2895082561 hasConceptScore W2895082561C86803240 @default.
• W2895082561 hasConceptScore W2895082561C95444343 @default.
• W2895082561 hasIssue "1" @default.
• W2895082561 hasLocation W28950825611 @default.
• W2895082561 hasOpenAccess W2895082561 @default.
• W2895082561 hasPrimaryLocation W28950825611 @default.
• W2895082561 hasRelatedWork W1985843533 @default.
• W2895082561 hasRelatedWork W2035855384 @default.
• W2895082561 hasRelatedWork W2082211144 @default.
• W2895082561 hasRelatedWork W2158987162 @default.
• W2895082561 hasRelatedWork W2257922556 @default.

• next