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- W2895090143 abstract "To summarize current evidence regarding the pathophysiology, diagnostic criteria, and management of IgG4 disease in the head and neck.The anti-CD20 antibody, rituximab is being used increasingly as a primary treatment modality in cases with a definitive diagnosis. Despite the favorable prognosis, it is now recognized that the incidence of cancer development within 3 years of diagnosis is higher than that of the general population.IgG4-related disease is a sclerosing, chronic inflammatory disease, that is benign, and usually occurs in middle-aged to elderly individuals. Definitive diagnosis of IgG4-related disease requires radiological confirmation of enlargement of the affected organ, elevated serum IgG4 levels, and characteristic histopathological findings. Treatment is primarily with systemic corticosteroids or the monoclonal anti-CD20 antibody rituximab, surgical excision, or a combination of treatment modalities. Prognosis is good with complete remission in up to 90% of patients." @default.
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- W2895090143 date "2018-12-01" @default.
- W2895090143 modified "2023-10-13" @default.
- W2895090143 title "IgG4-related disease in the head and neck" @default.
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- W2895090143 doi "https://doi.org/10.1097/moo.0000000000000487" @default.
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