Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895091112> ?p ?o ?g. }
- W2895091112 endingPage "e0204443" @default.
- W2895091112 startingPage "e0204443" @default.
- W2895091112 abstract "Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database.All spontaneous EV reports relating to loperamide misuse/abuse/dependence/withdrawal and cardiotoxicity issues were here retrieved, performing a descriptive analysis.During the years 2005-2017, EV collected a number of 1,983 (out of a total of 7,895; 25.11%) loperamide-related misuse/abuse/dependence/withdrawal adverse drug reaction (ADR) reports, with a progressively increasing trend since 2014. Most cases were classified as drug use disorder (37.4%) or intentional overdose (25.4%). Loperamide was used on its own in 41.9% of cases; remaining, polydrug, cases included antidepressants; benzodiazepines; and other OTCs. Some 1,085 (1,085/7,895 = 13.7%) cardiovascular ADRs were reported, being conduction abnormalities and EKG alterations the most frequently identified.EV data may support the levels of concern relating to loperamide potential of abuse and associated cardiotoxicity issues." @default.
- W2895091112 created "2018-10-12" @default.
- W2895091112 creator A5041705984 @default.
- W2895091112 creator A5078706372 @default.
- W2895091112 date "2018-10-04" @default.
- W2895091112 modified "2023-10-13" @default.
- W2895091112 title "Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports" @default.
- W2895091112 cites W1503987109 @default.
- W2895091112 cites W1586321124 @default.
- W2895091112 cites W1680603872 @default.
- W2895091112 cites W1802831456 @default.
- W2895091112 cites W1851433574 @default.
- W2895091112 cites W1965064439 @default.
- W2895091112 cites W1966467935 @default.
- W2895091112 cites W1985065867 @default.
- W2895091112 cites W1994342646 @default.
- W2895091112 cites W2026850615 @default.
- W2895091112 cites W2029910954 @default.
- W2895091112 cites W2032222317 @default.
- W2895091112 cites W2054238181 @default.
- W2895091112 cites W2072464207 @default.
- W2895091112 cites W2097951840 @default.
- W2895091112 cites W2125679749 @default.
- W2895091112 cites W2227363306 @default.
- W2895091112 cites W2232327264 @default.
- W2895091112 cites W2238903351 @default.
- W2895091112 cites W2257443024 @default.
- W2895091112 cites W2278938036 @default.
- W2895091112 cites W2316909494 @default.
- W2895091112 cites W2344752595 @default.
- W2895091112 cites W2421748441 @default.
- W2895091112 cites W2468660576 @default.
- W2895091112 cites W2484611738 @default.
- W2895091112 cites W2492347381 @default.
- W2895091112 cites W2513193734 @default.
- W2895091112 cites W2515229866 @default.
- W2895091112 cites W2546773764 @default.
- W2895091112 cites W2555559827 @default.
- W2895091112 cites W2560820278 @default.
- W2895091112 cites W2564078454 @default.
- W2895091112 cites W2568679968 @default.
- W2895091112 cites W2573726398 @default.
- W2895091112 cites W2586852594 @default.
- W2895091112 cites W2603981096 @default.
- W2895091112 cites W2611406155 @default.
- W2895091112 cites W2613063381 @default.
- W2895091112 cites W2613980613 @default.
- W2895091112 cites W2621353008 @default.
- W2895091112 cites W2747963321 @default.
- W2895091112 cites W2767303741 @default.
- W2895091112 cites W2780232501 @default.
- W2895091112 cites W2791883075 @default.
- W2895091112 cites W3006298854 @default.
- W2895091112 cites W817570268 @default.
- W2895091112 doi "https://doi.org/10.1371/journal.pone.0204443" @default.
- W2895091112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171858" @default.
- W2895091112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30286103" @default.
- W2895091112 hasPublicationYear "2018" @default.
- W2895091112 type Work @default.
- W2895091112 sameAs 2895091112 @default.
- W2895091112 citedByCount "30" @default.
- W2895091112 countsByYear W28950911122019 @default.
- W2895091112 countsByYear W28950911122020 @default.
- W2895091112 countsByYear W28950911122021 @default.
- W2895091112 countsByYear W28950911122022 @default.
- W2895091112 countsByYear W28950911122023 @default.
- W2895091112 crossrefType "journal-article" @default.
- W2895091112 hasAuthorship W2895091112A5041705984 @default.
- W2895091112 hasAuthorship W2895091112A5078706372 @default.
- W2895091112 hasBestOaLocation W28950911121 @default.
- W2895091112 hasConcept C118552586 @default.
- W2895091112 hasConcept C126322002 @default.
- W2895091112 hasConcept C2777573665 @default.
- W2895091112 hasConcept C2778233292 @default.
- W2895091112 hasConcept C2779802037 @default.
- W2895091112 hasConcept C2780035454 @default.
- W2895091112 hasConcept C2780542314 @default.
- W2895091112 hasConcept C29730261 @default.
- W2895091112 hasConcept C40010229 @default.
- W2895091112 hasConcept C57658597 @default.
- W2895091112 hasConcept C71924100 @default.
- W2895091112 hasConcept C98274493 @default.
- W2895091112 hasConceptScore W2895091112C118552586 @default.
- W2895091112 hasConceptScore W2895091112C126322002 @default.
- W2895091112 hasConceptScore W2895091112C2777573665 @default.
- W2895091112 hasConceptScore W2895091112C2778233292 @default.
- W2895091112 hasConceptScore W2895091112C2779802037 @default.
- W2895091112 hasConceptScore W2895091112C2780035454 @default.
- W2895091112 hasConceptScore W2895091112C2780542314 @default.
- W2895091112 hasConceptScore W2895091112C29730261 @default.
- W2895091112 hasConceptScore W2895091112C40010229 @default.
- W2895091112 hasConceptScore W2895091112C57658597 @default.
- W2895091112 hasConceptScore W2895091112C71924100 @default.
- W2895091112 hasConceptScore W2895091112C98274493 @default.
- W2895091112 hasIssue "10" @default.
- W2895091112 hasLocation W28950911121 @default.
- W2895091112 hasLocation W28950911122 @default.
- W2895091112 hasLocation W28950911123 @default.