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- W2895096471 abstract "Glaucoma is one of the leading causes of visual impairment and blindness worldwide. However, the cause of retinal ganglion cell loss and damage of the optic nerve in its pathogenesis is largely unknown. The high energy demands of these cells may reflect their strong dependence on mitochondrial function and thus sensitivity to mitochondrial defects. To address this issue, we studied whole mitochondrial genome variation in normal tension glaucoma patients and control individuals from the Polish population using next generation sequencing. Our findings indicate that few features of mitochondrial DNA variation are different for glaucoma patients and control subjects. New insights into normal tension glaucoma development are discussed. We provide also a comprehensive approach for mitochondrial DNA analysis and variant evaluation." @default.
- W2895096471 created "2018-10-12" @default.
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- W2895096471 date "2019-01-01" @default.
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- W2895096471 title "A new interpretation of the mechanism underlying visual anomalies of astronauts" @default.
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- W2895096471 doi "https://doi.org/10.1016/j.exer.2018.09.022" @default.
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