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• W2895119127 abstract "The present study was designed to synthesize a number of new Ceftriaxone derivatives by its involvement with a series of different amines, through the chemical derivatization of its 2-aminothiazolyl- group into an amide with chloroacetyl chloride, which on further conjugation with these selected amines will produce compounds with pharmacological effects that may extend the antimicrobial activity of the parent compound depending on the nature of these moieties.&#x0D; Ceftriaxone was first equipped with a spacer arm (linker) by the action of chloroacetyl chloride in aqueous medium and then further reacted with seven different aliphatic and aromatic amines which resulted in the production of the aimed final target products. The syntheses have been carried out following simple methodology in excellent isolated yields.&#x0D; The structure of the synthesized derivatives has been characterized by elemental microanalysis (CHN), FTIR spectroscopy, and other physicochemical properties. All the final synthesized compounds were screened for their antimicrobial activity against selected microorganisms and showed excellent antibacterial and antifungal activities in comparison to Ceftriaxone, Cephalexin and Fluconazole.&#x0D; The new Ceftriaxone derivatives have broadened the antimicrobial spectrum of the parent compound in having an extra antifungal activity in addition to its original antibacterial activity.&#x0D; Keywords: Ceftriaxone, 2-aminothiazole, Antimicrobial activity, Antifungal activity, Ceftriaxone derivatives." @default.
• W2895119127 created "2018-10-12" @default.
• W2895119127 creator A5064396900 @default.
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• W2895119127 date "2017-03-28" @default.
• W2895119127 modified "2023-09-24" @default.
• W2895119127 title "Synthesis, Characterization, and Antimicrobial Evaluation of New Ceftriaxone Derivatives" @default.
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• W2895119127 doi "https://doi.org/10.31351/vol23iss2pp75-88" @default.
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