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- W2895163062 endingPage "3029" @default.
- W2895163062 startingPage "3029" @default.
- W2895163062 abstract "Over half a century ago, British developmental biologist Conrad Hal Waddington proposed the idea of canalization, that is, homeostasis in development. Since the breakthrough that was made by Rutherford and Lindquist (1998), who proposed a role of Hsp90 in developmental buffering, chaperones have gained much attention in the study of canalization. However, recent studies have revealed that a number of other molecules are also potentially involved in canalization. Here, I introduce the emerging role of DnaJ chaperones in canalization. I also discuss how the expression levels of such buffering molecules can be altered, thereby altering organismal development. Since developmental robustness is maternally inherited in various organisms, I propose that dynamic bet hedging, an increase in within-clutch variation in offspring phenotypes that is caused by unpredictable environmental challenges to the mothers, plays a key role in altering the expression levels of buffering molecules. Investigating dynamic bet hedging at the molecular level and how it impacts upon morphological phenotypes will help our understanding of the molecular mechanisms of canalization and evolutionary processes." @default.
- W2895163062 created "2018-10-12" @default.
- W2895163062 creator A5053802180 @default.
- W2895163062 date "2018-10-04" @default.
- W2895163062 modified "2023-10-05" @default.
- W2895163062 title "Chaperones, Canalization, and Evolution of Animal Forms" @default.
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